| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
Epigenetic mechanisms that are governed by histone acetylation are considered to have a critical role in neuronal differentiation. In this analysis, we have attempted to generate transgenic mice that would be capable of decreasing an expression level of CBP protein, a causative protein for Rubinstein-Taybi syndrome. In addition, we have analyzed effects of in utero exposure of valproate, a putative candidate for treating Rubinstein-Taybi syndrome, on cerebral cortical histogenesis. Valproate exposure in utero increased the thickness of cerebral cortex by affecting the cell cycle kinetics of neuronal progenitor cells.
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