Roles of epigenetic mechanism on cerebral cortical histogenesis in congenital malformation syndrome
Project/Area Number |
26293248
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Keio University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
小崎 健次郎 慶應義塾大学, 医学部, 教授 (30234743)
三橋 隆行 慶應義塾大学, 医学部, 講師 (80338110)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
|
Keywords | 神経発生 / 大脳皮質 / エピゲノム / 細胞周期 / 小児神経 / 大脳皮質発生 / 神経幹細胞 |
Outline of Final Research Achievements |
Epigenetic mechanisms that are governed by histone acetylation are considered to have a critical role in neuronal differentiation. In this analysis, we have attempted to generate transgenic mice that would be capable of decreasing an expression level of CBP protein, a causative protein for Rubinstein-Taybi syndrome. In addition, we have analyzed effects of in utero exposure of valproate, a putative candidate for treating Rubinstein-Taybi syndrome, on cerebral cortical histogenesis. Valproate exposure in utero increased the thickness of cerebral cortex by affecting the cell cycle kinetics of neuronal progenitor cells.
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Report
(4 results)
Research Products
(4 results)