| Project/Area Number |
26293251
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹谷 健 島根大学, 医学部, 講師 (30359880)
竹谷 英之 東京大学, 医科学研究所, 講師 (90206996)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROSE Jun 東京大学医科学研究所附属病院, 関節外科, 特任助教 (00456112)
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| Research Collaborator |
MUKAI Takeo
MORI Yuka
Hori Akiko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 臍帯 / 間葉系細胞 / 新生児脳性麻痺 / 新生児慢性肺疾患 / 血友病B / 再生医療 / 免疫療法 / 新生児 / 新生児脳症 / 移植・再生医療 / トランスレーショナルリサーチ / 再生医学 / 免疫学 / 血友病 / 肝炎 / 脳性麻痺 / 慢性呼吸器疾患 |
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| Outline of Final Research Achievements |
This study aimed at making disease specific model mice treated with umbilical cord-derived mesenchymal stromal cells (UC-MSC). As the model of neonatal encephalopathy, we made mice with intraventricular hemorrhage and found the UC-MSC ameliorated the neuromuscular functions and protect the reactive gliosis. We also made the newborn chronic lung disease induced by hyperoxygen, and the UC-MSC also improved the overall survival with decrease of inflammatory cytokines and interstitial fibrosis. Hemophilia B mice were induced hepatic disorder by CCl4 and UC-MSC could migrate to the injured tissue, but failed to ameliorate the damage and survival at the presence. Conclusively, UC-MSC may be useful for neonatal complications such as neuropathy and lung disease.
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