New tissue-repair and immuno-regulatory therapy with umbilical cord-derived mesenchymal stromal cells
| Project/Area Number |
26293251
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹谷 健 島根大学, 医学部, 講師 (30359880)
竹谷 英之 東京大学, 医科学研究所, 講師 (90206996)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROSE Jun 東京大学医科学研究所附属病院, 関節外科, 特任助教 (00456112)
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| Research Collaborator |
MUKAI Takeo
MORI Yuka
Hori Akiko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 臍帯 / 間葉系細胞 / 新生児脳性麻痺 / 新生児慢性肺疾患 / 血友病B / 再生医療 / 免疫療法 / 新生児 / 新生児脳症 / 移植・再生医療 / トランスレーショナルリサーチ / 再生医学 / 免疫学 / 血友病 / 肝炎 / 脳性麻痺 / 慢性呼吸器疾患 |
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| Outline of Final Research Achievements |
This study aimed at making disease specific model mice treated with umbilical cord-derived mesenchymal stromal cells (UC-MSC). As the model of neonatal encephalopathy, we made mice with intraventricular hemorrhage and found the UC-MSC ameliorated the neuromuscular functions and protect the reactive gliosis. We also made the newborn chronic lung disease induced by hyperoxygen, and the UC-MSC also improved the overall survival with decrease of inflammatory cytokines and interstitial fibrosis. Hemophilia B mice were induced hepatic disorder by CCl4 and UC-MSC could migrate to the injured tissue, but failed to ameliorate the damage and survival at the presence. Conclusively, UC-MSC may be useful for neonatal complications such as neuropathy and lung disease.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Ex Vivo Expanded Allogeneic Mesenchymal Stem Cells with Bone Marrow Transplantation Improved Osteogenesis in Infants with Severe Hypophosphatasia2015
Author(s)
Taketani T, Oyama C, Mihara A, Tanabe Y, Abe M, Hirade T, Yamamoto S, Bo R, Kanai R, Tadenuma T, Michibata Y, Yamamoto S, Hattori M, Katsube Y, Ohnishi H, Sasao M, Oda Y, Hattori K, Yuba S, Ohgushi H, Yamaguchi S
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Journal Title
Cell Transplant.
Volume: 24
Issue: 10
Pages: 1931-1943
DOI
Related Report
Peer Reviewed / Open Access
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