Neurocomputation of schizophrenia pathophysiology based on the two-photon synaptic imaging in vivo
| Project/Area Number |
26293260
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Gunma University (2016-2017)
The University of Tokyo (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田中 昌司 上智大学, 理工学部, 教授 (30188304)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 統合失調症 / シナプス / 2光子イメージング / シナプス後電流 / 巨大スパイン / 2光子励起イメージング / 神経発火 / GCaMP6f / 精神疾患 / コンピューテーション / 樹状突起スパイン / カルシウムイメージング / DISC1 |
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| Outline of Final Research Achievements |
DISC1 is one of schizophrenia-related gene. We performed the longitudinal in vivo imaging analysis of the brain of DISC1 knockdown model, and we found this model exhibited decrease in the dendritic spine and the significant increase in the huge spines. The existent of the huge spines in this model mice is interesting because another schizophrenia model mice, Calcineurin knockout mice also exhibited this phenomenon. Given that there is the strong correlation between spine head size and its synaptic efficacy, the huge spine can generate larger synaptic current. Furthermore, multiple synaptic inputs are integrated in dendrite, resulting in the generation of NMDA spike, and simultaneous inputs within dendritic segment induces supralinear effect for the generation of NMDA spike. We are now demonstrating that the larger current through the huge spine would significantly change dendritic integration, resulting in disorganized firing.
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Report
(5 results)
Research Products
(30 results)
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[Journal Article] Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype.2017
Author(s)
Zhang JC, Yao W, Qu Y, Nakamura M, Dong C, Yang C, Ren Q, Ma M, Han M, Shirayama Y, Hayashi-Takagi A, Hashimoto K
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A critical time window for dopamine actions on the structural plasticity of dendritic spines.2014
Author(s)
Yagishita, S., Hayashi-Takagi, A., Ellis-Davies, G.C.R., Urakubo, H., Ishii, S., & Kasai, H.
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Journal Title
Science
Volume: 345
Issue: 6204
Pages: 1616-1620
DOI
Related Report
Peer Reviewed
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[Journal Article] PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence2014
Author(s)
Hayashi-Takagi, A., Araki, Y., Nakamura, M., Vollrath, B., Duron, S.G., Yan, Z., Kasai, H., Huganir, R.L., Campbell, D.A. & Sawa, A.
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Journal Title
Proc. Natl. Acad. Sci. U.S.A.
Volume: 111
Issue: 17
Pages: 6461-6
DOI
Related Report
Peer Reviewed
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