| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
DISC1 is one of schizophrenia-related gene. We performed the longitudinal in vivo imaging analysis of the brain of DISC1 knockdown model, and we found this model exhibited decrease in the dendritic spine and the significant increase in the huge spines. The existent of the huge spines in this model mice is interesting because another schizophrenia model mice, Calcineurin knockout mice also exhibited this phenomenon. Given that there is the strong correlation between spine head size and its synaptic efficacy, the huge spine can generate larger synaptic current. Furthermore, multiple synaptic inputs are integrated in dendrite, resulting in the generation of NMDA spike, and simultaneous inputs within dendritic segment induces supralinear effect for the generation of NMDA spike. We are now demonstrating that the larger current through the huge spine would significantly change dendritic integration, resulting in disorganized firing.
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