The genotype, the phenotype and the end-phenotype measured by MEG in autism spectrum disorder.
Project/Area Number |
26293262
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Kanazawa University |
Principal Investigator |
Kikuchi Mitsuru 金沢大学, 子どものこころの発達研究センター, 教授 (00377384)
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Co-Investigator(Kenkyū-buntansha) |
横山 茂 金沢大学, 子どものこころの発達研究センター, 教授 (00210633)
真田 茂 金沢大学, 保健学系, 教授 (50020029)
吉村 優子 金沢大学, 子どものこころの発達研究センター, 助教 (70597070)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
|
Keywords | 自閉スペクトラム症 / 脳磁図 / 幼児 / 遺伝子多型 / MET遺伝子 / 社会性 / ワーキングメモリ / 言語発達 / 脳内ネットワーク / 遺伝子 / 自閉症 / 中間表現型 / 脳磁図計 / 自閉症スペクトラム |
Outline of Final Research Achievements |
The symptom of ASD was evaluated using the behavioral and neurophysiological methods. We researched the effect of the genotype (which was thought to be risk type for ASD) on phenotype measured by behavioral data and end-phenotype measured by MEG. Young children with ASD (N=71: including the repeated subjects) and typically developing children (N=102: including the repeated subjects) participated. At the present moment, single nucleotide polymorphism of rs1858830 in a MET gene have identified in 33 children with ASD and 30 TD children. We defined CC and a CG genotype (which include risk type genetic polymorphism C) as CC_CG group, and we compared some phenotype and end-phenotype between CC_CG and GG groups. As the result, in the ASD group including genetic polymorphism C, developmental delay was observed in working memory task. On the other hand, TD group was affected by the risk gene more about the latency of auditory evoked field measured by MEG.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Mu rhythm suppression reflects mother-child face-to-face interactions: a pilot study with simultaneous MEG recording2016
Author(s)
Hasegawa C, Ikeda T, Yoshimura Y, Hiraishi H, Takahashi T, Furutani N, Hayashi N, Minabe Y, Hirata M, Asada M, Kikuchi M
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 34977-34977
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder.2016
Author(s)
Yoshimura, Y., Kikuchi, M., Hiraishi, H., Hasegawa, C., Takahashi, T., Remijn, G.B., Oi, M., Munesue, T., Higashida, H., & Minabe, Y.
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Journal Title
NeuroImage: Clinical
Volume: 12
Pages: 300-305
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism.2016
Author(s)
Kurita T, Kikuchi M, Yoshimura Y, Hiraishi H, Hasegawa C, Takahashi T, Hirosawa T, Furutani N, Higashida H, Ikeda T, Mutou K, Asada M, Minabe Y.
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Journal Title
PLoS One
Volume: 13
Issue: 4
Pages: 0153077-0153077
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Unusual developmental pattern of brain lateralization in young boys with autism spectrum disorder: Power analysis with child-sized magnetoencephalography.2015
Author(s)
Hiraishi H, Kikuchi M, Yoshimura Y, Kitagawa S, Hasegawa C, Munesue T, Takesaki N, Ono Y, Takahashi T, Suzuki M, Higashida H, Asada M, Minabe Y.
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Journal Title
Psychiatry Clin Neurosci
Volume: 69
Issue: 3
Pages: 153-160
DOI
Related Report
Peer Reviewed
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[Journal Article] Attentional control and interpretation of facial expression after oxytocin administration to typically developed male adults.2015
Author(s)
Hirosawa T, Kikuchi M, Okumura E, Yoshimura Y, Hiraishi H, Munesue T, Takesaki N, Furutani N, Ono Y, Higashida H, Minabe Y
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Journal Title
PLoS One
Volume: 6
Issue: 2
Pages: e0116918-e0116918
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A longitudinal study of auditory evoked field and language development in young children2014
Author(s)
Yoshimura Yuko, Kikuchi Mitsuru, Ueno Sanae, Shitamichi Kiyomi, Remijn Gerard, Hiraishi Hirotoshi, Hasegawa Chiaki, Furutani Naoki, Oi Manabu, Munesue Toshio, Tsubokawa Tunehisa, Higashida Haruhiro, Minabe Yoshio
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Journal Title
NeuroImage
Volume: 1;101
Pages: 440-447
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Atypical bilateral brain synchronization in the early stage of human voice auditory processing in young children with autism2016
Author(s)
Toshiharu Kurita, Mitsuru Kikuchi,Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Tetsu Hirosawa, Naoki Furutani, Haruhiro Higashida, Takashi Ikeda, Kouhei Mutou, Minoru Asada, and Yoshio Minabe
Organizer
第31回日本生体磁気学会大会
Place of Presentation
金沢市文化ホール(金沢市)
Related Report
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[Presentation] Enhanced functional network in autism spectrum disorder during early childhood2016
Author(s)
Yoshiaki Miyagishi, Tetsuya Takahashi, Teruya Yamanishi, Shinya Kasakawa, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsu Hirosawa, Toshio Munesue, Haruhiro Higashida, Yoshio Minabe, and Mitsuru Kikuchi
Organizer
第31回日本生体磁気学会大会
Place of Presentation
金沢市文化ホール(金沢市)
Related Report
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[Presentation] Brain connectivity during a high-level visual perceptual task in young ASD children: a MEG investigation2015
Author(s)
Mitsuru Kikuchi, Laurent Mottron, Natsumi Takesaki, Tetsuya Takahashi, Tetsu Hirosawa, Yuko Yoshimura, Naoki Furutani, Hirotoshi Hiraishi, Chiaki Hasegawa, Sachiko Kitagawa, Yoshio Minabe
Organizer
The International Meeting for Autism Research.
Place of Presentation
Salt Lake City, Utah, USA.
Year and Date
2015-05-16
Related Report
Invited
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[Presentation] Mental rotation: a high-level perceptual strength of young ASD children.2015
Author(s)
Yuko Yoshimura, Laurent Mottron, Natsumi Takesaki,Tetsuya Takahashi, Tetsu Hirosawa, Naoki Furutani,Hirotoshi Hiraishi, Chiaki Hasegawa, Sachiko Kitagawa, Yoshio Minabe, Mitsuru Kikuchi
Organizer
The International Meeting for Autism Research.
Place of Presentation
Salt Lake City, Utah, USA.
Year and Date
2015-05-16
Related Report
Invited
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