In vivo imaging study for the timing of neurogenesis and neuroinflammation altered in Alzheimer's disease
Project/Area Number |
26293263
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
Yasuomi Ouchi 浜松医科大学, 光尖端医学教育研究センター, 教授 (40436978)
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Co-Investigator(Kenkyū-buntansha) |
間賀田 泰寛 浜松医科大学, 光尖端医学教育研究センター, 教授 (20209399)
植木 孝俊 名古屋市立大学, 医学(系)研究科(研究院), 教授 (60317328)
寺田 達弘 浜松医科大学, 光尖端医学教育研究センター, 特任研究員 (80550178)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
Keywords | アルツハイマー病 / 神経新生 / ミクログリア活性 / 神経炎症 / 老年精神医学 / 活性化ミクログリア |
Outline of Final Research Achievements |
We examined molecules that relate to microglial activation and investigated a linkage between neurogenesis and neuroinflammation using AD-like animal models (SAMP8 mice and naturally-developed demented macaque confirmed by [11C]PIB for amyloid pathology) by developing methods with which we were able to quantify the amount of neurogenesis and determine the types of microglial activation: protective or inflammatory. With the SAMP8 mice, a combination of Nestin promoter LAT4 system and [18F]dFMT enabled to illustrate the neurogenesis but the signal was small and ex vivo postmortem brain imaging was found to be necessary. Using a CB2R ligand permitted to depict microglial activation, but we found a more sensitive probe and method system necessary for examining these two phenomena in vivo in a living single animal.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195.2016
Author(s)
Yokokura M, Terada T, Bunai T, Nakaizumi K, Takebayashi K, Iwata Y, Yoshikawa E, Futatsubashi M, Suzuki K, Mori N, Ouchi Y.
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Journal Title
J Cereb Blood Flow Metab.
Volume: 37
Issue: 3
Pages: 877-889
DOI
Related Report
Peer Reviewed
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[Journal Article] Florbetaben Phase 3 Study Group. Florbetaben PET imaging to detect amyloid plaques in Alzheimer disease2015
Author(s)
Sabri O, Sabbagh MN, Seibyl J, Barthel H, Akatsu H, Ouchi Y, Senda K, Murayama S, Ishii K, Takao M, Beach TG, Rowe CC, Leverenz JB, Ghetti B, Ironside JW, Catafau AM, Stephens AW, Mueller A, Koglin N, Hoffmann A, Roth K, Reininger C, Schulz-Schaeffer WJ
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Journal Title
Alzheimers Dement
Volume: 11
Issue: 8
Pages: 964-974
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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