Development of nuclear medical imaging probes targeting cerebral amyloid antipathy
| Project/Area Number |
26293274
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
Ono Masahiro 京都大学, 薬学研究科(研究院), 准教授 (80336180)
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| Co-Investigator(Renkei-kenkyūsha) |
TEMMA Takashi 京都大学, 大学院薬学研究科, 助教 (90378787)
KIMURA Hiroyuki 京都大学, 放射性同位元素総合センター, 助教 (50437240)
SANO Kohei 京都大学, 大学院医学研究科, 助教 (00546476)
WATANABE Hiroyuki 京都大学, 大学院薬学研究科, 研究員 (40710786)
IHARA Masafumi 国立循環器病研究センター, 脳血管内科, 医長 (00372590)
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| Research Collaborator |
MATSUMURA Kenji 京都大学, 大学院薬学研究科, 大学院生
YOSHIMURA Masashi 京都大学, 大学院薬学研究科, 大学院生
IIKUNI Shimpei 京都大学, 大学院薬学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 脳アミロイドアンギオパチー / イメージング / 金属錯体 / 診断 / βアミロイド |
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| Outline of Final Research Achievements |
Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid aggregates in the walls of cerebral vasculature, and constitutes a major factor in intracerebral hemorrhage and vascular cognitive impairment. In this study, we carried out the development of nuclear medical imaging probes targeting CAA. As a result, we successfully developed a novel 99mTc complex that showed selective binding to CAA while it did not show marked radioactivity accumulation in senile plaques in the cortex.
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Report
(4 results)
Research Products
(8 results)
