| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
In this study, we aimed to develop comprehensive cellular therapy for acute syndrome and late effects associated with radiation-induced tissue/organ injuries by use of differential regenerative functions of hematopoietic stem cells (HSCs) and mesenchymal stem/stromal cells (MSCs). We found that dual transplantation of HSCs and MSCs ameliorates skin and large bowel injuries associated with acute radiation exposure and graft-versus-host disease compared with transplant of HSCs alone in an irradiated (8 Gy) mouse model. Intriguingly, such protective effect was reproducible in mice receiving HSCs with culture supernatant of MSCs instead of MSCs themselves. We also established a unique method to efficiently isolate MSCs from human umbilical cord blood for the future MSC banking system free from invasive procedures to the donors .
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