Development of pH-weighted MR imaging for assessment of tissue prognosis in acute brain infarction

• Project/Area Number: 26293278
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kagoshima University
• Principal Investigator: Yoshiura Takashi 鹿児島大学, 医歯学域医学系, 教授 (40322747)
• Co-Investigator(Kenkyū-buntansha): 福倉 良彦 鹿児島大学, 医歯学域医学部・歯学部附属病院, 准教授 (50315412) ; 樋渡 昭雄 九州大学, 大学病院, 助教 (30444855) ; 栂尾 理 九州大学, 大学病院, 助教 (10452749) ; 山下 孝二 九州大学, 大学病院, 助教 (80546565) ; 吾郷 哲朗 九州大学, 大学病院, 助教 (30514202) ; 本田 浩 九州大学, 医学(系)研究科(研究院), 教授 (90145433) ; 熊澤 誠志 北海道科学大学, 保健医療学部, 教授 (50363354)
• Research Collaborator: KEUPP Jochen Philips Research
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: MRI / 脳 / 脳梗塞 / 分子イメージング / pH / ｐH

Outline of Final Research Achievements

We developed and optimized pH weighted magnetic resonance (MR) imaging, which is based on amide proton transfer (APT) through in vitro phantom experiments and imaging of clinical patients with acute brain infarction. Optimal strength and duration of the saturation pulse were determined, and a 3D APT imaging covering the whole brain method was implemented. We investigated a new method of image analysis that can acquire APT-related signal more efficiently. We analyzed images of clinical patients with acute brain infarction by comparing findings from conventional MR images, and found that the APT signal as measured with magnetization transfer ration (MTR) asymmetry at 3.5 ppm was reduced from 0.26% (normal region) to -0.48% (infarction) on average, and that this APT signal reduction was clearly visible in 37% of the included cases. Our study revealed that ph-weighted MR imaging based on APT is feasible in detection of anaerobic metabolism due to acute bran infarction in clinical patients.

Research Products

• [Journal Article] CEST MRイメージングの臨床応用 (2017)
  • Author(s): 吉浦 敬
  • Journal Title: JSMI Report Volume: 10(1) Pages: 24-28
• [Journal Article] Amide proton transfer imaging of brain tumors using a self-corrected 3D fast spin-echo Dixon method: Comparison with separate B0 correction (2017)
  • Author(s): Togao O, Keupp J, Hiwatashi A, Yamashita K, Kikuchi K, Yoneyama M, Honda H
  • Journal Title: Magn Reson Med Volume: 印刷中 Issue: 6 Pages: 2272-2279
  • DOI: 10.1002/mrm.26322
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging (2017)
  • Author(s): Togao O, Hiwatashi A, Yamashita K, Kikuchi K, Keupp J, Yoshimoto K, Kuga D, Yoneyama M, Suzuki SO, Iwaki T, Takahashi M, Iihara K, Honda H
  • Journal Title: Eur Radiol Volume: 27(2) Issue: 2 Pages: 578-588
  • DOI: 10.1007/s00330-016-4328-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Glycosaminoglycan chemical exchange saturation transfer in human lumbar intervertebral discs: Effect of saturation pulse and relationship with low back pain (2017)
  • Author(s): Wada T, Togao O, Tokunaga C, Funatsu R, Yamashita Y, Kobayashi K, Nakamura Y, Honda H
  • Journal Title: J Magn Reson Imaging Volume: 45(3) Issue: 3 Pages: 863-871
  • DOI: 10.1002/jmri.25397
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intravoxel Incoherent Motion in Normal Pituitary Gland: Initial Study with Turbo Spin-Echo Diffusion-Weighted Imaging (2016)
  • Author(s): Kamimura K, Nakajo M, Fukukura Y, Iwanaga T, Saito T, Sasaki M, Fujisaki T, Takemura A, Okuaki T, Yoshiura T
  • Journal Title: AJNR Am J Neuroradiol Volume: 37(12) Pages: 2328-2333
  • Peer Reviewed
• [Journal Article] Amide Proton Transfer Imaging of Diffuse Gliomas: Effect of Saturation Pulse Length in Parallel Transmission-Based Technique (2016)
  • Author(s): Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoshiura T, Yoneyama M, Kruiskamp MJ, Sagiyama K, Takahashi M, Honda H
  • Journal Title: PLoS One Volume: 11(5) Issue: 5 Pages: e0155925-e0155925
  • DOI: 10.1371/journal.pone.0155925
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Amide proton transfer (APT) magnetic resonance imaging of prostate cancer: comparison with Gleason scores (2016)
  • Author(s): Takayama Y, Nishie A, Sugimoto M, Togao O, Asayama Y, Ishigami K, Ushijima Y, Okamoto D, Fujita N, Yokomizo A, Keupp J, Honda H
  • Journal Title: MAGMA Volume: 29(4) Issue: 4 Pages: 671-679
  • DOI: 10.1007/s10334-016-0537-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors (2015)
  • Author(s): Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoshiura T, Suzuki Y, Kruiskamp MJ, SagiyamaK, Takahashi M, Honda H
  • Journal Title: J Magn Reson Imaging Volume: 未定 Issue: 5 Pages: 1346-1353
  • DOI: 10.1002/jmri.24895
  • Peer Reviewed
• [Journal Article] Amide Proton Transfer（APT）イメージング (2014)
  • Author(s): 栂尾理，樋渡昭雄，山下孝二，菊地一史，本田浩
  • Journal Title: 日獨医報 Volume: 59 Pages: 124-137
• [Journal Article] CEST －CESTイメージングの臨床応用とその課題 (2014)
  • Author(s): 栂尾理，樋渡昭雄，山下孝二，菊地一史，本田浩，吉浦敬，鈴木由里子，Jochen Keupp
  • Journal Title: インナービジョン Volume: 9 Pages: 10-14
• [Journal Article] The effect of the saturation pulse duration on chemical exchange saturation transfer in amide proton transfer MR imaging: a phantom study
  • Author(s): Wada T, Togao O, Tokunaga C, Funatsu R, Kobayashi K. Nakamura Y
  • Journal Title: Radiol Phys Technol Volume: 未定
  • Peer Reviewed
• [Presentation] 脳の非造影MRIアップデート (2017)
  • Author(s): 吉浦 敬
  • Organizer: 第40回日本脳神経CI学会総会
  • Place of Presentation: 鹿児島サンロイヤルホテル（鹿児島県鹿児島市）
  • Year and Date: 2017-03-03
• [Presentation] 神経放射線領域における最新の画像検査 (2017)
  • Author(s): 吉浦 敬
  • Organizer: 第4回臨地実習指導者講習会
  • Place of Presentation: 九州大学病院キャンパス基礎研究Ｂ棟（福岡県福岡市）
  • Invited
• [Presentation] 中枢神経診断における新たなMRシークエンスの臨床応用：オンコロジー & 血流イメージング (2017)
  • Author(s): 栂尾理
  • Organizer: 第10回大分ラジオロジー・ミーティング
  • Place of Presentation: 別府亀の井ホテル（大分県別府市）
  • Invited
• [Presentation] Clinical application of CEST/APT Imaging (2017)
  • Author(s): 栂尾理
  • Organizer: Neuro MR Expert Meeting
  • Place of Presentation: ソラシティカンファレンスセンター（東京都千代田区）
  • Invited
• [Presentation] Clinical application of CEST/APT Imaging (2016)
  • Author(s): Togao O
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: ソニック大宮（埼玉県大宮市）
  • Year and Date: 2016-09-09
  • Int'l Joint Research
• [Presentation] pH 強調 APTイメージングにおける飽和パルスの持続時間と強度の影響 (2016)
  • Author(s): 徳永千晶、和田達弘、山下泰生、小林幸次、栂尾理
  • Organizer: 第11回日本分子イメージング学会総会・学術集会
  • Place of Presentation: ソニック大宮（埼玉県大宮市）
  • Year and Date: 2016-09-09
• [Presentation] Readout RFパルスが脳腫瘍のamide proton transferイメージングに及ぼす影響 (2016)
  • Author(s): 和田達弘、徳永千晶、山下泰生、小林幸次、栂尾理
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: ソニック大宮（大宮市）
  • Year and Date: 2016-09-09
• [Presentation] CEST MRイメージングの臨床応用 (2016)
  • Author(s): 吉浦 敬
  • Organizer: 第11回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2016-05-28
  • Int'l Joint Research
• [Presentation] Amide proton transfer (APT) imaging of brain tumors using a self-corrected 3D fast spin-echo Dixon method: comparison with separate B0 mapping (2016)
  • Author(s): Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoneyama M, Honda H
  • Organizer: 24th Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine
  • Place of Presentation: シンガポール（シンガポール）
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Latest topics of brain MRI ～beyond the clinical routine ～ (2016)
  • Author(s): 吉浦 敬
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-04-14
  • Int'l Joint Research / Invited
• [Presentation] APTイメージングにおけるpH依存性の検討 (2016)
  • Author(s): 和田 達弘、栂尾 理、小林 幸次
  • Organizer: 第97回MR研究会／第16回一般研究発
  • Place of Presentation: アクロス福岡（福岡県福岡市）
  • Year and Date: 2016-01-16
• [Presentation] 脳神経MRIのトピックス：脳腫瘍, 血管, 神経イメージング (2016)
  • Author(s): 栂尾理
  • Organizer: 第100回 MR研究会
  • Place of Presentation: アクロス福岡（福岡県福岡市）
  • Invited
• [Presentation] MRIで見えるもの (2016)
  • Author(s): 吉浦 敬
  • Organizer: 天陽会研究発表会
  • Place of Presentation: 天陽会中央病院（鹿児島県鹿児島市）
  • Invited
• [Presentation] MR分子イメージングの新たな展開 (2015)
  • Author(s): 吉浦 敬
  • Organizer: 第278回Open Film Conference
  • Place of Presentation: マーキュリーホテル前橋（群馬県前橋市）
  • Year and Date: 2015-11-19
  • Invited
• [Presentation] 先進MRIが切り開く画像診断の新たな可能性：CEST／APTイメージング (2015)
  • Author(s): 吉浦 敬
  • Organizer: 第51回日本医学放射線学会秋季臨床大会
  • Place of Presentation: アイーナ岩手県民情報交流センター(岩手県盛岡市）
  • Year and Date: 2015-10-02
• [Presentation] Assessment of glycosaminoglycan content in lumbar intervertebral discs with chemical exchange (2015)
  • Author(s): Togao O, Hiwatashi A, Wada T, Yamashita K, Kikuchi K, Tokunaga C, Suzuki Y, Keupp J, Honda H
  • Organizer: 23rd Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine
  • Place of Presentation: トロント(カナダ)
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Chemical Exchange Saturation Transfer （CEST）イメージング (2014)
  • Author(s): 吉浦 敬
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡 福岡国際会議場
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] Amide Proton Transferにおける飽和パルスの印加時間がCEST効果に及ぼす影響 (2014)
  • Author(s): 和田達弘、栂尾 理、他
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2014-04-10 – 2014-04-13