Analysis of the pathway of Smo transcription for development of new therapeutic strategy inhibiting Hedgehog signaling
Project/Area Number |
26293289
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Kyushu University |
Principal Investigator |
ONISHI HIDEYA 九州大学, 医学研究院, 准教授 (30553276)
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Co-Investigator(Kenkyū-buntansha) |
中野 賢二 九州大学, 先端融合医療レドックスナビ研究拠点, 教授 (00315061)
野村 政壽 九州大学, 大学病院, 講師 (30315080)
久保 真 九州大学, 大学病院, 助教 (60403961)
中村 勝也 九州大学, 医学(系)研究科(研究院), 共同研究員 (60585743)
山崎 章生 九州大学, 医学(系)研究科(研究院), 共同研究員 (80404440)
片野 光男 九州大学, 医学(系)研究科(研究院), 教授 (10145203)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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Keywords | 膵癌 / Hedgehogシグナル / Smoothened / 低酸素環境 / 悪性形質誘導 / 増殖能 / 浸潤能 / 転写活性 / ヘッジホッグシグナル / 転写活性化亢進 / 膵癌悪性形質 / 膵癌増殖 / 膵癌浸潤 / Smoothened転写 / 癌予防法開発 / 新規治療法開発 / smo転写活性 / RBPJ / MAML3 / 膵がん / 増殖 / 浸潤 / 新規治療標的 / Smoothened転写活性 / Notchシグナル / 膵臓癌 / 治療標的 |
Outline of Final Research Achievements |
We found that transcriptional factor, recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and transcriptional coactivator, mastermind like-3 (MAML3) contribute to the mechanism of upregulation of Smootnened (SMO) transcription under hypoxia, and that inhibition of RBPJ/MAML3 signaling suppress the inducing of malignant phenotype such as proliferation, invasion and tumorigenesis in pancreatic cancer.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells.2016
Author(s)
Suyama K, Onishi H, Imaizumi A, Shinkai K, Umebayashi M, Kubo M, Mizuuchi Y, Oda Y, Tanaka M, Nakamura M, Katano M.
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Journal Title
Cancer Letters
Volume: 374(1)
Issue: 1
Pages: 44-53
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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