Infection control based on photodynamic effect and new treatment for pressure ulcer by promoting wound healing
| Project/Area Number |
26293295
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | National Defense Medical College |
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Principal Investigator |
Morimoto Yuji 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 医学教育部医学科専門課程, 准教授 (10449069)
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| Co-Investigator(Kenkyū-buntansha) |
青木 伊知男 国立研究開発法人量子科学技術研究開発機構, その他部局等, 研究員 (10319519)
佐藤 貴浩 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, その他部局等, 教授 (30235361)
木下 学 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, その他部局等, 准教授 (70531391)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Keywords | 光線力学療法 / 外科学 / 感染症 / 細菌 / 免疫学 / 外科 / 光線力学治療 |
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| Outline of Final Research Achievements |
Based on photodynamic therapy (PDT), we studied the Infection control and developed a new treatment for pressure ulcer by promoting wound healing.
1. Study using subcutaneous soft tissue infection model mice: A) PDT conditions inducing maximization of treatment efficiency were found. B) Visualization of neutrophil kinetics after PDT was succeeded. C) Signal transduction related to neutrophil migration / accumulation was clarified. 2. We succeeded in promoting granulation and epithelialization by PDT on the skin defect model mice and clarified the conditions for controlling its effect. 3. Aiming at the construction of a next-generation homogeneous irradiation system that incorporates a feedback system that can correct light intensity unhomogenuity, we have developed basic technology for intensity unhomogenuity correction.
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| Academic Significance and Societal Importance of the Research Achievements |
PDTを用いた感染症治療に関しては、これまで皮膚などの外表面における感染対策が中心であったが、本技術開発により皮膚のみならず皮下組織や軟部組織等の生体深部においても治療が可能となる。また、本研究での抗菌効果の実証は、薬剤耐性を示す菌に対するPDTによる感染制御効果の典型的事例を示すことになるだけでなく、PDTの持つ創傷治癒促進効果を利用した治療期間の短縮にもつながる技術となる。これらの技術開発は、褥瘡など難治性の病変に対しても朗報をもたらすことが期待できる。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities.2017
Author(s)
Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjyo Y, Ichinose T, Tokuno SI, Ishizuka T, Nakata T, Mizutani A, Umemura N, Kitani A, Fuss IJ, Shigehiro T, Kawaki H, Mizuno-Kamiya M, Kondoh N, Seno M.
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Journal Title
Oncol Rep
Volume: 38
Issue: 1
Pages: 449-455
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy2016
Author(s)
T. Nomoto, S. Fukushima, M. Kumagai, K. Miyazaki, A. Inoue, P. Mi, Y. Maeda, K. Toh, Y. Matsumoto, Y. Morimoto, A. Kishimura, N. Nishiyama, K. Kataoka
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Journal Title
Biomater. Sci.
Volume: 印刷中
Issue: 5
Pages: 826-838
DOI
Related Report
Peer Reviewed
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