Establishment of new treatment by thrombopoietin receptor agonist for liver regeneration in liver cirrhosis and for prevention of liver carcinogenes
| Project/Area Number |
26293296
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
千葉 満 弘前大学, 保健学研究科, 講師 (20583735)
村田 聡一郎 横浜市立大学, 医学部, 准教授 (40436275)
松原 由美子 慶應義塾大学, 医学部, 准教授 (70365427)
倉田 昌直 筑波大学, 医学医療系, 教授 (20538665)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 肝硬変 / 肝細胞癌 / 肝線維化改善 / 抗がん作用 / 肝再生 / 血小板 / トロンボポエチン / 経口血小板増多剤 / 経口血小板増多薬 / 線維化改善 / 発癌予防法 |
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| Outline of Final Research Achievements |
We aimed at the establishment of new treatments for liver regeneration in chronic hepatitis, liver fibrosis, and for prevention of liver carcinogenesis by thrombopoietin receptor agonist. Eltrombopag is the only available drug of oral thrombopoietin receptor agonist. It’s receptor exists only in humans and chimpanzees, so we tried to create genetically modified mice, but we did not establish. We evaluate the effect of eltrombopag in clinical trials for patients with chronic hepatitis. Transfusion of platelets has effect on liver generation, but eltrombopag have no such an effect. Recently, glycans of platelets participate in mechanism of platelets feedback by receptor in liver. We clarified that desialylation were occurred when platelets activated. In vitro, we elucidated that eltrombopag inhibit cell growth of hepatocellular carcinoma(HCC) by effect of iron chelation. So we started the clinical trial of therapy for HCC patients by eltrombopag.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Protecting liver sinusoidal endothelial cells suppresses apoptosis in acute liver damage.2016
Author(s)
Tanoi T, Tamura T, Sano N, Nakayama K, Fukunaga K, Zheng YW, Akhter A, Sakurai Y, Hayashi Y, Harashima H, Ohkohchi N.
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Journal Title
Hepatol Res
Volume: 未定
Issue: 7
Pages: 697-706
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury.2015
Author(s)
Sano N, Tamura T, Toriyabe N, Nowatari T, Nakayama K, Tanoi T, Murata S, Sakurai Y, Hyodo M, Fukunaga K, Harashima H, Ohkohchi N.
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Journal Title
World J Gastroenterol.
Volume: 21
Issue: 45
Pages: 12778-12786
DOI
Related Report
Peer Reviewed
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[Presentation] Cytoprotective effect of hyaluronic acid-modified sphingosine-1-phosphate on experimental hepatic ischemia-reperfusion injury2015
Author(s)
Sano N, Tamura T, Toriyabe N, Nowatari T, Nakayama K, Tanoi T, Sakurai Y, Hyodo M, Harashima H, Ohkohchi N
Organizer
APDW 2015 TIPEI Advances in Digestive Medicine
Place of Presentation
Taipei International Convention Center(Taipei,Taiwan)
Year and Date
2015-12-03
Related Report
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