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Development of innovative peptide vaccine therapy using iPS cell-derived dendritic cells against pancreatic cancer patients

Research Project

Project/Area Number 26293308
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionWakayama Medical University

Principal Investigator

Yamaue Hiroki  和歌山県立医科大学, 医学部, 教授 (20191190)

Co-Investigator(Kenkyū-buntansha) 清水 敦史  和歌山県立医科大学, 医学部, 学内助教 (00637910)
川井 学  和歌山県立医科大学, 医学部, 准教授 (40398459)
岡田 健一  和歌山県立医科大学, 医学部, 講師 (50407988)
尾島 敏康  和歌山県立医科大学, 医学部, 講師 (60448785)
廣野 誠子  和歌山県立医科大学, 医学部, 講師 (60468288)
宮澤 基樹  和歌山県立医科大学, 医学部, 助教 (90549734)
谷 眞至  和歌山県立医科大学, 医学部, 准教授 (60236677)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
KeywordsiPS細胞 / 樹状細胞 / がんワクチン療法 / 細胞傷害性Tリンパ球 / 膵癌免疫療法 / iPS / 癌ワクチン / ペプチドワクチン / 癌
Outline of Final Research Achievements

We investigated whether human induced pluripotent stem cell (iPSC)-derived dendritic cells (hiPSDCs) pulsed with cocktail peptide (KIF 20 A, MUC 16, Mesothelin, VEGFR 1, R 2) could induce pancreatic cancer cell-specific cytotoxic T cells in a preclinical model using pancreatic cancer patients. The surface marker expression, cytokine secretion and migratory capacity of the hiPSDCs were equivalent between pancreatic cancer patients and healthy volunteers. Cytotoxic T cells activated by cocktail peptide pulsed hiPSDCs exhibited pancreatic cancer cells-specific cytotoxic activity against the target cells. This was the first study to show an antitumor effect on pancreatic cancer cells by vaccination with iPSDCs. This innovative cocktail peptide pulsed hiPSDCs is a promising tool for clinical applications of vaccine therapy for treating pancreatic cancer patients.

Report

(4 results)
  • 2017 Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (63 results)

All 2017 2016 2015 2014

All Journal Article (44 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 43 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Int'l Joint Research: 1 results) Book (4 results)

  • [Journal Article] Percutaneous and endoscopic gallbladder drainage for acute cholecystitis: international multicenter comparative study using propensity score-matched analysis2017

    • Author(s)
      Itoi T, Takada T, Hwang TL, Endo I, Akazawa K, Miura F, Chen MF, Jan YY, Ker CG, Wang HP, Gomi H, Yokoe M, Kiriyama S, Yamaue H, Miyazaki M, Yamamoto M.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 24 Issue: 6 Pages: 362

    • DOI

      10.1002/jhbp.454

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Updated comprehensive epidemiology, microbiology, and outcomes among patients with acute cholangitis2017

    • Author(s)
      Gomi H, Takada T, Hwang TL, Akazawa K, Mori R, Endo I, Miura F, Kiriyama S, Matsunaga N, Itoi T, Yokoe M, Chen MF, Jan YY, Ker CG, Wang HP, Wada K, Yamaue H, Miyazaki M, Yamamoto M.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 24 Issue: 6 Pages: 310

    • DOI

      10.1002/jhbp.452

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circular stapling versus triangulating stapling for the cervical esophagogastric anastomosis after esophagectomy in patients with thoracic esophageal cancer: A prospective, randomized, controlled trial.2017

    • Author(s)
      Hayata K, Nakamori M, Nakamura M, Ojima T, Iwahashi M, Katsuda M, Tsuji T, Kato T, Kitadani J, Takeuchi A, Tabata H, Yamaue H.
    • Journal Title

      Surgery.

      Volume: in press Issue: 1 Pages: 131-138

    • DOI

      10.1016/j.surg.2017.01.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Descriptive review of acute cholecystitis: Japan-Taiwan collaborative epidemiological study2017

    • Author(s)
      Yokoe M, Takada T, Hwang TL, Endo I, Akazawa K, Miura F, Mayumi T, Mori R, Chen MF, Jan YY, Ker CG, Wang HP, Itoi T, Gomi H, Kiriyama S, Yamaue H, Miyazaki M, Yamamoto M.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 24 Issue: 6 Pages: 319

    • DOI

      10.1002/jhbp.450

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter, randomized, open-label Phase II study comparing S-1 alternate-day oral therapy with the standard daily regimen as a first-line treatment in patients with unresectable advanced pancreatic cancer.2017

    • Author(s)
      Yamaue H, Shimizu A, Hagiwara Y, Sho M, Yanagimoto H, Nakamori S, Ueno H, Ishii H, Kitano M, Sugimori K, Maguchi H, Ohkawa S, Imaoka H, Hashimoto D, Ueda K, Nebiki H, Nagakawa T, Isayama H, Yokota I, Ohashi Y, Shirasaka T.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: in press Issue: 4 Pages: 813-823

    • DOI

      10.1007/s00280-017-3250-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of intra-abdominal absorbable sutures on surgical site infection in gastrointestinal and hepato-biliary-pancreatic surgery: results of a multicenter, randomized, prospective, phase II clinical trial.2017

    • Author(s)
      Maehara Y, Shirabe K, Kohnoe S, Emi Y, Oki E, Kakeji Y, Baba H, Ikeda M, Kobayashi M, Takayama T, Natsugoe S, Haraguchi M, Yoshida K, Terashima M, Sasako M, Yamaue H, Kokudo N, Uesaka K, Uemoto S, Kosuge T, Sawa Y, Shimada M, Doki Y, Yamamoto M, Taketomi A, Takeuchi M, Akazawa K, Yamanaka T, Shimokawa M.
    • Journal Title

      Surg Today.

      Volume: in press Issue: 9 Pages: 1060-1071

    • DOI

      10.1007/s00595-017-1480-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laparoscopic Gastrojejunostomy for Patients with Unresectable Gastric Cancer with Gastric Outlet Obstruction.2017

    • Author(s)
      Ojima T, Nakamori M, Nakamura M, Katsuda M, Hayata K, Yamaue H.
    • Journal Title

      J Gastrointest Surg.

      Volume: in press Issue: 8 Pages: 1220-1225

    • DOI

      10.1007/s11605-017-3387-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phase I Study of Nab-Paclitaxel plus Gemcitabine as Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer.2017

    • Author(s)
      Okada KI, Hirono S, Kawai M, Miyazawa M, Shimizu A, Kitahata Y, Ueno M, Hayami S, Yamaue H.
    • Journal Title

      Anticancer Res.

      Volume: 37 Pages: 853-858

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors Associated With Invasive Intraductal Papillary Mucinous Carcinoma of the Pancreas.2017

    • Author(s)
      Hirono S, Kawai M, Okada KI, Miyazawa M, Shimizu A, Kitahata Y, Ueno M, Yanagisawa A, Yamaue H.
    • Journal Title

      JAMA Surg.

      Volume: 152 Issue: 3 Pages: e165054-e165054

    • DOI

      10.1001/jamasurg.2016.5054

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Partial clamping of the infrahepatic inferior vena cava for blood loss reduction during anatomic liver resection: A prospective, randomized, controlled trial.2017

    • Author(s)
      Ueno M, Kawai M, Hayami S, Hirono S, Okada KI, Uchiyama K, Yamaue H.
    • Journal Title

      Surgery.

      Volume: in press Issue: 6 Pages: 1502-1513

    • DOI

      10.1016/j.surg.2016.12.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perineural Invasion Is Associated with Poor Survival after Preoperative Chemoradiation Therapy for Advanced Lower Rectal Cancer.2017

    • Author(s)
      Yokoyama S, Matsuda K, Watanabe T, Mitani Y, Ieda J, Iwamoto H, Hotta T, Takifuji K, Yamaue H
    • Journal Title

      Dig Surg.

      Volume: in press Issue: 5 Pages: 387-393

    • DOI

      10.1159/000453591

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Value of apparent diffusion coefficient prior to neoadjuvant therapy is a predictor of histologic response in patients with borderline resectable pancreatic carcinoma.2017

    • Author(s)
      Okada KI, Hirono S, Kawai M, Miyazawa M, Shimizu A, Kitahata Y, Ueno M, Hayami S, Kojima F, Yamaue H.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 24 Issue: 3 Pages: 161-168

    • DOI

      10.1002/jhbp.430

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II clinical trial using novel peptide cocktail vaccine as a postoperative adjuvant treatment for surgically resected pancreatic cancer patients.2017

    • Author(s)
      Miyazawa M, Katsuda M, Maguchi H, Katanuma A, Ishii H, Ozaka M, Yamao K, Imaoka H, Kawai M, Hirono S, Okada KI, Yamaue H.
    • Journal Title

      Int J Cancer.

      Volume: 140 Issue: 4 Pages: 973-982

    • DOI

      10.1002/ijc.30510

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of preoperative fluorodeoxyglucose-positron emission tomography in prediction of tumor recurrence after liver transplantation for hepatocellular carcinoma patients: a Japanese multicenter study.2017

    • Author(s)
      Takada Y, Kaido T, Shirabe K, Nagano H, Egawa H, Yamaue H.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 24 Issue: 1 Pages: 49-57

    • DOI

      10.1002/jhbp.412

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole genome sequencing discriminates hepatocellular carcinoma with intrahepatic metastasis from multi-centric tumors2017

    • Author(s)
      Furuta M, Ueno M, Fujimoto A, Hayami S, Yasukawa S, Kojima F, Arihiro K, Kawakami Y, Wardell CP, Shiraishi Y, Tanaka H, Nakano K, Maejima K, Sasaki-Oku A, Tokunaga N, Boroevich KA, Abe T, Aikata H, Ohdan H, Gotoh K, Kubo M, Tsunoda T, Miyano S, Chayama K, Yamaue H, Nakagawa H
    • Journal Title

      J Hepatol

      Volume: 66(2) Issue: 2 Pages: 363-373

    • DOI

      10.1016/j.jhep.2016.09.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of BRCA1, a factor closely associated with relapse-free survival, in patients who underwent neoadjuvant chemotherapy with docetaxel, cisplatin, and fluorouracil for squamous cell carcinoma of the esophagus.2017

    • Author(s)
      Ojima T, Nakamori M, Nakamura M, Katsuda M, Hayata K, Nakamura Y, Yamaue H.
    • Journal Title

      Surg Today.

      Volume: 47 Pages: 65-73

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical trials to reduce pancreatic fistula after pancreatic surgery-review of randomized controlled trials.2016

    • Author(s)
      Kitahata Y, Kawai M, Yamaue H.
    • Journal Title

      Transl Gastroenterol Hepatol.

      Volume: 1 Pages: 4-4

    • DOI

      10.21037/tgh.2016.03.19

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of Endoscopic Submucosal Dissection for Submucosal-invasive Gastric Cancer and the Predictors of Residual or Recurrent Cancer.2016

    • Author(s)
      Ojima T, Takifuji K, Nakamura M, Nakamori M, Yamaue H.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech.

      Volume: 26 Pages: 401-405

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological Characteristics of Young Patients With Pancreatic Cancer: An Analysis of Data From Pancreatic Cancer Registry of Japan Pancreas Society.2016

    • Author(s)
      Eguchi H, Yamaue H, Unno M, Mizuma M, Hamada S, Igarashi H, Kuroki T, Satoi S, Shimizu Y, Tani M, Tanno S, Hirooka Y, Fujii T, Masamune A, Mizumoto K, Itoi T, Egawa S, Kodama Y, Tanaka M, Shimosegawa T
    • Journal Title

      Pancreas.

      Volume: 45 Pages: 1411-1417

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment Strategy for Borderline Resectable Pancreatic Cancer With Radiographic Artery Involvement.2016

    • Author(s)
      Hirono S, Kawai M, Okada KI, Miyazawa M, Shimizu A, Kitahata Y, Ueno M, Yamaue H.
    • Journal Title

      Pancreas.

      Volume: 45 Pages: 1438-1446

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of treatment duration of neoadjuvant FIRINOX in patients with borderline resectable pancreatic cancer: a pilot trial.2016

    • Author(s)
      Okada K., Ioka T., et al.
    • Journal Title

      Cancer Chemother. Pharmacol.

      Volume: 78(4) Issue: 4 Pages: 719-26

    • DOI

      10.1007/s00280-016-3121-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of rikkunshito on body weight loss after esophagectomy.2016

    • Author(s)
      Nakamura M, Nakamori M, Ojima T, Katsuda M, Hayata K, Iwahashi M, Yamaue H.
    • Journal Title

      J Surg Res.

      Volume: 204 Issue: 1 Pages: 130-138

    • DOI

      10.1016/j.jss.2016.04.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells.2016

    • Author(s)
      Kitahata Y, Kanuma T, Hayashi M, Kobayashi N, Ozasa K, Kusakabe T, Temizoz B, Kuroda E, Yamaue H, Coban C, Yamamoto T, Kobiyama K, Aoshi T, Ishii KJ.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 31 Pages: 48860-48869

    • DOI

      10.18632/oncotarget.10379

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survival outcome of salvage hepatectomy in patients with local, recurrent hepatocellular carcinoma who underwent radiofrequency ablation as their first treatment.2016

    • Author(s)
      Ueno M, Nakai T, Hayashi M, Hirokawa F, Nagano H, Wada H, Kaibori M, Matsui K, Tanaka S, Yamaue H, Kubo S.
    • Journal Title

      Surgery.

      Volume: 160 Issue: 3 Pages: 661-670

    • DOI

      10.1016/j.surg.2016.04.023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term surveillance is necessary after operative resection for intraductal papillary mucinous neoplasm of the pancreas.2016

    • Author(s)
      Hirono S, Kawai M, Okada K, Miyazawa M, Shimizu A, Kitahata Y, Ueno M, Yanagisawa A, Yamaue H.
    • Journal Title

      Surgery.

      Volume: 160 Issue: 2 Pages: 306-317

    • DOI

      10.1016/j.surg.2016.04.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grade B pancreatic fistulas do not affect survival after pancreatectomy for pancreatic cancer: A multicenter observational study.2016

    • Author(s)
      Kawai M, Yamaue H. et al.
    • Journal Title

      Surgery

      Volume: xxx Issue: 2 Pages: 293-305

    • DOI

      10.1016/j.surg.2016.02.032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole genome mutational landscape and characterization of non-coding and structural mutations in liver cancer.2016

    • Author(s)
      Fujimoto A et al.
    • Journal Title

      Nat Genet

      Volume: 48 Issue: 5 Pages: 500-509

    • DOI

      10.1038/ng.3547

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the efficacy of daikenchuto (TJ -100) for the prevention of paralytic ileus after pancreaticoduodenectomy: A multicenter, double-blind, randomized, placebo-controlled trial.2016

    • Author(s)
      Okada K, Kawai M, Hirono S, Fujii T, Kodera Y, Sho M, Nakajima Y, Satoi S, Kwon AH, Shimizu Y, Ambo Y, Kondo N, Murakami Y, Ohuchida J, Eguchi H, Nagano H, Oba MS, Morita S, Sakamoto J, Yamaue H.
    • Journal Title

      Surgery.

      Volume: 159 Issue: 5 Pages: 1333-1341

    • DOI

      10.1016/j.surg.2015.11.019

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Randomized Controlled Trial of Pancreaticojejunostomy versus Stapler Closure of the Pancreatic Stump During Distal Pancreatectomy to Reduce Pancreatic Fistula.2016

    • Author(s)
      Kawai M, Hirono S, Okada K, Sho M, Nakajima Y, Eguchi H, Nagano H, Ikoma H, Morimura R, Takeda Y, Nakahira S, Suzumura K, Fujimoto J, Yamaue H.
    • Journal Title

      Ann Surg.

      Volume: 264 Issue: 1 Pages: 180-187

    • DOI

      10.1097/sla.0000000000001395

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma.2016

    • Author(s)
      Yachida S, Wood LD, Suzuki M, et al.Takai E, Totoki Y, Kato M, Luchini C, Arai Y, Nakamura H, Hama N, Elzawahry A, Hosoda F, Shirota T, Morimoto N, Hori K, Funazaki J, Tanaka H, Morizane C, Okusaka T, Nara S, Shimada K, Hiraoka N, Taniguchi H, Higuchi R, Oshima M, Okano K, Hirono S, Mizuma M, Arihiro K, et al.
    • Journal Title

      Cancer Cell

      Volume: 29 Issue: 2 Pages: 229-240

    • DOI

      10.1016/j.ccell.2015.12.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Randomized Controlled Trial of Pancreaticojejunostomy versus Stapler Closure of the Pancreatic Stump During Distal Pancreatectomy to Reduce Pancreatic Fistula.2016

    • Author(s)
      Kawai M, Hirono S, Okada KI, Sho M, Nakajima Y, Eguchi H, Nagano H, Ikoma H, Morimura R, Takeda Y, Nakahira S, Suzumura K, Fujimoto J, Yamaue H
    • Journal Title

      Ann Surg

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 2015 Guidance on cancer immunotherapy development in early-phase clinical studies2015

    • Author(s)
      Guidance Development Review Committee; Working Group for Clinical Studies of Cancer Immunotherapy; Working Group for Effector Cell Therapy; Working Group for CMC/Non-clinical Studies; Working Group for Cancer Vaccines and Adjuvants; Working Group for Anti-immune Checkpoint Therapy and Comprehensive Cancer
    • Journal Title

      Cancer Sci

      Volume: 106 Issue: 12 Pages: 1761

    • DOI

      10.1111/cas.12819

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Randomized phase II/III clinical trial of elpamotide forpatients with advanced pancreatic cancer: PEGASUS-PC Study.2015

    • Author(s)
      Yamaue H, Tsunoda T, Tani M, Miyazawa M, Yamao K, Mizuno N, Okusaka T, Ueno H,Boku N, Fukutomi A, Ishii H, Ohkawa S, Furukawa M, Maguchi H, Ikeda M, Togashi Y,Nishio K, Ohashi Y.
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 7 Pages: 883-890

    • DOI

      10.1111/cas.12674

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Validation of a Nomogram for Predicting the Probability of Carcinoma in Patients With Intraductal Papillary Mucinous Neoplasm in 180 Pancreatic Resection Patients at 3 High-Volume Centers.2015

    • Author(s)
      Shimizu Y, Yamaue H, Maguchi H, Yamao K, Hirono S, Osanai M, Hijioka S, Kanemitsu Y, Sano T, Senda Y, Bhatia V, Yanagisawa A
    • Journal Title

      Pancreas.

      Volume: 44 Pages: 459-64

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tips and tricks of the surgical technique for borderline resectable pancreatic cancer: mesenteric approach and modified distal pancreatectomy with en-bloc celiac axis resection.2015

    • Author(s)
      Hirono S, Yamaue H
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 22

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A replaced right hepatic artery adjacent to pancreatic carcinoma should be divided to obtain R0 resection in pancreaticoduodenectomy.2015

    • Author(s)
      Okada K, Kawai M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Tani M, Yamaue H
    • Journal Title

      Langenbecks Arch Surg

      Volume: 400 Pages: 57-65

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Risk Factors for Pancreatic Exocrine Insufficiency After Pancreaticoduodenectomy Using a 13C-Labeled Mixed Triglyceride Breath Test.2015

    • Author(s)
      Hirono S, Murakami Y, Tani M, Kawai M, Okada K, Uemura K, Sudo T, Hashimoto Y, Nakagawa N, Kondo N, Yamaue H
    • Journal Title

      World J Surg

      Volume: 39 Pages: 516-25

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preservation of the Left Gastric Artery on the Basis of Anatomical Features in Patients Undergoing Distal Pancreatectomy with Celiac Axis En-bloc Resection (DP-CAR).2014

    • Author(s)
      Okada K, Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H
    • Journal Title

      World J Surg

      Volume: 38 Pages: 2980-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Randomized clinical trial of isolated Roux-en-Y versus conventional reconstruction after pancreaticoduodenectomy.2014

    • Author(s)
      Tani M, Kawai M, Hirono S, Okada K, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H
    • Journal Title

      Br J Surg

      Volume: 101 Pages: 1084-91

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative cholangitis during biliary drainage increases the incidence of postoperative severe complications after pancreaticoduodenectomy.2014

    • Author(s)
      Kitahata Y, Kawai M, Tani M, Hirono S, Okada K, Miyazawa M, Shimizu A, Yamaue H
    • Journal Title

      Am J Surg

      Volume: 208 Pages: 1-10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pylorus-Resecting Pancreaticoduodenectomy Offers Long-Term Outcomes Similar to Those of Pylorus-Preserving Pancreaticoduodenectomy: Results of a Prospective Study.2014

    • Author(s)
      Kawai M, Tani M, Hirono S, Okada K, Miyazawa M, Yamaue H
    • Journal Title

      World J Surg

      Volume: 38 Pages: 1476-1483

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer.2014

    • Author(s)
      Yamaue H, Satoi S, Kanbe T, Miyazawa M, Tani M, Kawai M, Hirono S, Okada K, Yanagimoto H, Kwon AH, Mukouyama T, Tsunoda H, Chijiiwa K, Ohuchida J, Kato J, Ueda K, Yamaguchi T, Egawa S, Hayashi K, Shirasaka T
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 73 Pages: 97-102

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Isolated Roux-en-Y anastomosis of the pancreatic stump in a duct-to-mucosa fashion in patients with distal pancreatectomy with en-bloc celiac axis resection.2014

    • Author(s)
      Okada K, Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 21 Pages: 193-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor immune response of dendritic cells (DCs) expressing tumor-associated antigens derived from induced pluripotent stem cells: In comparison to bone marrow-derived DCs.2014

    • Author(s)
      Iwamoto H, Ojima T, Hayata K, Katsuda M, Miyazawa M, Iida T, Nakamura M, Nakamori M, Iwahashi M, Yamaue H
    • Journal Title

      Int J Cancer

      Volume: 134 Pages: 332-341

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cancer Vaccine Therapy using iPS-derived Dendritic Cells2016

    • Author(s)
      Toshiyasu Ojima, Hiromitsu Iwamoto, Junya Kitadani, Hirotaka Tabata, Mikihito Nakamori, Masaki Nakamura, Masahiro Katsuda, Keiji Hayata, Tomoya Kato, Akihiro Takeuchi, and Hiroki Yamaue
    • Organizer
      The 54 th Annual Meeting of Japanese Society of Clinical Oncology
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cancer Vaccine Therapy using iPS-derived Dendritic Cells2016

    • Author(s)
      Toshiyasu Ojima, Hiromitsu Iwamoto, Junya Kitadani, Hirotaka Tabata, Mikihito Nakamori, Masaki Nakamura, Masahiro Katsuda, Keiji Hayata, Tomoya Kato, Akihiro Takeuchi, and Hiroki Yamaue
    • Organizer
      The 25 th Annual Meeting of Japanese Society of Strategies for Cancer Research and Therapy
    • Place of Presentation
      千葉
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 臨床応用に向けた腫瘍抗原(TAA)遺伝子導入iPS細胞由来樹状細胞(iPSDCs)癌ワクチン療法の改善点2016

    • Author(s)
      岩本博光
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] The cancer vaccine therapy using DCs derived from iPS cells (iPSDCs) expressing TAA gene2016

    • Author(s)
      岩本博光
    • Organizer
      ASCO-GI 2016
    • Place of Presentation
      San Francisco U.S.A
    • Year and Date
      2016-01-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腫瘍抗原遺伝子導入ヒトiPS細胞由来樹状細胞(iPSDCs)による抗腫瘍効果の検討2015

    • Author(s)
      北谷純也
    • Organizer
      第43回和歌山悪性腫瘍研究会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] iPS細胞由来樹状細胞(iPSDCs)癌ワクチン治療戦略のこれまでの研究成果と今後の課題2015

    • Author(s)
      岩本博光
    • Organizer
      第43回和歌山悪性腫瘍研究会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腫瘍抗原遺伝子導入ヒトiPS細胞由来樹状細胞(iPSDCs)による抗腫瘍効果の検討2015

    • Author(s)
      北谷純也
    • Organizer
      第28回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      川越
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] iPS細胞由来樹状細胞(iPSDCs)癌ワクチン療法の基礎研究と臨床応用への道筋 A basic research and the road to a clinical application of the cancer vaccine therapy using iPSDCs2015

    • Author(s)
      岩本博光
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] CEA遺伝子導入人工多能性幹細胞(iPS細胞)由来樹状細胞を用いた癌ワクチン療法の基礎研究2015

    • Author(s)
      北谷純也
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腫瘍抗原遺伝子導入ヒトiPS細胞由来樹状細胞(iPSDCs)による抗腫瘍効果の検討2015

    • Author(s)
      北谷純也
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] iPS細胞由来樹状細胞(iPSDCs)癌ワクチン療法のこれまでの基礎研究の成果と臨床応用に向けての課題2015

    • Author(s)
      岩本博光
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] CEA遺伝子導入iPS細胞由来樹状細胞を用いた癌ワクチン療法の可能性2015

    • Author(s)
      尾島敏康,岩本博光,北谷純也,山上裕機
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] The use of an interposed graft during portal vein and/or superior mesenteric vein reconstruction in pancreatic resection for pancreatic cancer.2015

    • Author(s)
      Yamaue H
    • Organizer
      Gastrointestinal Cancers Symposium 2015
    • Place of Presentation
      America
    • Year and Date
      2015-01-15 – 2015-01-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Can We Reduce Complications Following Pancreatoduodenectomy? The Mesenteric Approach and Clinical Trials2014

    • Author(s)
      Yamaue H
    • Organizer
      45th Anniversary Meeting of the American Pancreatic Association & Japan Pancreas Society
    • Place of Presentation
      America
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] The impact of preservation of left gastric artery in distal pacreatectomy with celiac axis en-bloc resection(CP-CAR):Proposal of a novel surgical technique to reduce delayed gastric emptying.2014

    • Author(s)
      Yamaue H, Kawai M, Okada K, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y
    • Organizer
      48th Annual Meeting of Pancreas Club
    • Place of Presentation
      America
    • Year and Date
      2014-05-02 – 2014-05-03
    • Related Report
      2014 Annual Research Report
  • [Book] 消化器疾患 最新の治療 2015-20162015

    • Author(s)
      谷 眞至,山上裕機
    • Total Pages
      3
    • Publisher
      南江堂
    • Related Report
      2014 Annual Research Report
  • [Book] 分子細胞治療フロンティア20152014

    • Author(s)
      勝田将裕,山上裕機
    • Total Pages
      8
    • Publisher
      外科分子治療研究会
    • Related Report
      2014 Annual Research Report
  • [Book] 膵癌治療 up-to-date 20152014

    • Author(s)
      谷 眞至,山上裕機
    • Total Pages
      8
    • Publisher
      医学図書出版
    • Related Report
      2014 Annual Research Report
  • [Book] 膵癌治療 up-to-date 20152014

    • Author(s)
      廣野誠子,山上裕機
    • Total Pages
      6
    • Publisher
      医学図書出版
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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