Regenerative therapy for postoperative paraplegia after thoracic aortic surgery using bone marrow stem cell cultured in microgravity
| Project/Area Number |
26293312
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
Sueda Taijiro 広島大学, 医歯薬保健学研究院(医), 教授 (10162835)
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| Co-Investigator(Kenkyū-buntansha) |
弓削 類 広島大学, 医歯薬保健学研究院(保), 教授 (20263676)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 胸腹部大動脈瘤 / 対麻痺 / 脊髄再生 / 骨髄間葉系幹細胞 / 微小重力培養 / 神経分化誘導 / 神経幹細胞 / 脊髄障害 / 間葉系幹細胞 / GFP / 胸部大動脈瘤 / 脊髄間葉系幹細胞 / 大動脈瘤手術 / 脊髄虚血 / 神経再生 / 脊髄再生治療 |
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| Outline of Final Research Achievements |
Paraplegia is devastating complication after thoracoabdominal aortic surgery. Bone marrow stem cell was cultivated using the microgravited (10-3G) culture device (Gravite). Bone marrow stem cell can be cultivated under undifferentiated condition by microgravitated clture device. Rat paraplegia model was made using simple balloon occlusion of descending aorta for 30min. Control group (serine), simple cultivated bone marrow stem cells and microgravitated bone marrow stem cells were injected into rat paraplegia model via tail vein. Bone marrow degeneration can be treated by injection of cultivated bone marrow stem cells.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] The impact of preoperative identification of the Adamkiewicz artery on descending and thoracoabdominal aortic repair2015
Author(s)
Tanaka H, Ogino H, Minatoya K, Matsui Y, Higami T, Okabatashi H, Sakai Y, Aomi Y, Shiiya N, Sawa Y, Okota Y, Sueda T, Akashi H, Kuniyoshi Y, Katsumata T
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Journal Title
J Thorac Cardiovasc Surg
Volume: 151
Pages: 122-8
Related Report
Peer Reviewed / Open Access
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