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Regenerative therapy for postoperative paraplegia after thoracic aortic surgery using bone marrow stem cell cultured in microgravity

Research Project

Project/Area Number 26293312
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionHiroshima University

Principal Investigator

Sueda Taijiro  広島大学, 医歯薬保健学研究院(医), 教授 (10162835)

Co-Investigator(Kenkyū-buntansha) 弓削 類  広島大学, 医歯薬保健学研究院(保), 教授 (20263676)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords胸腹部大動脈瘤 / 対麻痺 / 脊髄再生 / 骨髄間葉系幹細胞 / 微小重力培養 / 神経分化誘導 / 神経幹細胞 / 脊髄障害 / 間葉系幹細胞 / GFP / 胸部大動脈瘤 / 脊髄間葉系幹細胞 / 大動脈瘤手術 / 脊髄虚血 / 神経再生 / 脊髄再生治療
Outline of Final Research Achievements

Paraplegia is devastating complication after thoracoabdominal aortic surgery. Bone marrow stem cell was cultivated using the microgravited (10-3G) culture device (Gravite). Bone marrow stem cell can be cultivated under undifferentiated condition by microgravitated clture device. Rat paraplegia model was made using simple balloon occlusion of descending aorta for 30min. Control group (serine), simple cultivated bone marrow stem cells and microgravitated bone marrow stem cells were injected into rat paraplegia model via tail vein. Bone marrow degeneration can be treated by injection of cultivated bone marrow stem cells.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014

All Journal Article (18 results) (of which Peer Reviewed: 17 results,  Open Access: 17 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] A novel blood viscosity estimation based on pressure -flow characteristics of an oxygenator during cardiopulmonary bypass2017

    • Author(s)
      Okahara S, Soh Z, Miyamoto S, Takahahsi H, Takahashi S, Sueda T, Tsuji T
    • Journal Title

      Artif Organs

      Volume: 41 Pages: 262-266

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood viscosity monitoring during cardiopulmonary bypass based on pressure-flow chracteristics of a Newtonian fluid2016

    • Author(s)
      Okahara S, Zu Soh, Takahahsi S Sueda T, Tsuji T
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 759 Pages: 1197-1199

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intraoperative factors postoperative atrial fibrillation? Reply2016

    • Author(s)
      Takahashi S, Sueda T
    • Journal Title

      Cir J

      Volume: Epub ahead Frb Pages: 8-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Iliac artery stenting combined with open iliofemoral endarterectomy facilitated by a novel ultrasonic ablation instrument for diffuse iliofemoral occlusive disease2016

    • Author(s)
      Takahashi S, Taguchi T, Dohi Y, Sueda T
    • Journal Title

      Ann Vasc Surg

      Volume: 31 Pages: 13-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preoperative tissue Doppler imaging-derived atrial conduction time predict postoperative atrail fibrillation in patients undergoing mitral valve surgery for mitral valve regurgitation2016

    • Author(s)
      Takahashi S, Katayama K, Watanabe M, Kodama H, Taguchi T, Kurosaki T, Imai K, Sueda T
    • Journal Title

      Cir J

      Volume: 80 Pages: 101-109

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Iliac artery stenting combined with open iliofemoral endoarterectomy facilitated by a novel ultrasonic ablation instrument for diffuse iliofemoral occlusive disease2016

    • Author(s)
      Takahahsi S, Taguchi T, Dohi Y, Sueda T
    • Journal Title

      Ann Vas Surg

      Volume: 31 Pages: 13-16

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The relationship between inflammation and neoangiogenesis of epicardial adipose tissue and coronary atherosclerosis based on computed tomography analysis2015

    • Author(s)
      Kitagawa T, Tamamoto H, Sentani K, Takahahsi S, Tsushima H, Senoo A, Yasui W, SuedaT
    • Journal Title

      Atherosclerosis

      Volume: 243 Pages: 293-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of preoperative identification of the Adamkiewicz artery on descending and thoracoabdominal aortic repair2015

    • Author(s)
      Tanaka H, Ogino H, Minatoya K, Matsui Y, Higami T, Okabatashi H, Sakai Y, Aomi Y, Shiiya N, Sawa Y, Okota Y, Sueda T, Akashi H, Kuniyoshi Y, Katsumata T
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 151 Pages: 122-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of cardiopulmonary rehabilitation with adaptive servo-ventilation in patients undergoing off-pump coronary artery bypass grafting2015

    • Author(s)
      Tashiro N, Takahahsi S, Takasaki T, Katayama K, Taguchi T, Watanabe M, Kurosaki T, Imai K, Sueda T
    • Journal Title

      Cir J

      Volume: 79 Pages: 1290-8

    • NAID

      130005073148

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Postoperative atrial fibrillation after thoracic aortic surgery2015

    • Author(s)
      Arakawa M, Miyata H, Uchida N, Motomura N, Katayama A, Tamura K, Sueda T, Takamoto S
    • Journal Title

      Asian Cardiovasc Thorac Ann

      Volume: 99 Pages: 103-108

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A successful hybrid repair for vertebral arteriovenous fistula with extracranial vertebral artery aneurysm2015

    • Author(s)
      Takahashi S, Katayama K, Tatsugawa T, Sueda T
    • Journal Title

      Ann Vas Surg

      Volume: 29 Pages: 5-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prestenotic and post stenotic multiple aneurysms with adult coactation2014

    • Author(s)
      Katayama K, Uchida N, Takasaki T, Sueda T
    • Journal Title

      J Vasc surg

      Volume: 60 Pages: 234-235

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple factors predict the risk of spinal cord injury after the frozen elephant trunk technique for extended thoracic aortic disease.2014

    • Author(s)
      Katayama K, Uchida N, Katayama A, Takahashi S, Takasaki T, Kurosaki T, Imai K, Sueda T
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 47 Issue: 4 Pages: 616-620

    • DOI

      10.1093/ejcts/ezu243

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delayed surgery for type A aortic dissection caused by blunt trauma2014

    • Author(s)
      Takahashi S, Uchida N, Takasaki T, Sueda T
    • Journal Title

      Asian Cardiovasc Thorac Ann

      Volume: 23 Pages: 206-208

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transintercostal-evoked spinal cord potential in thoracic aortic surgery2014

    • Author(s)
      Takahashi S, Orihahsi K, Imai K, Mizukami T, Takasaki T, Sueda T
    • Journal Title

      Ann Vasc Surg

      Volume: 28 Pages: 1775-1781

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trehalose protects against spinal cord ischemia in rabbits2014

    • Author(s)
      Takahashi S, Isaka M, Hamamoto M, Imai K, Orihahsi K, Sueda T
    • Journal Title

      J Vasc Surg

      Volume: 60 Pages: 490-496

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of somatosensory-evoked cortical responses by a weak leading stimulus2014

    • Author(s)
      Nakagawa K, Inui K, Yuge L, Kakigi R
    • Journal Title

      Neuroimage

      Volume: 101 Pages: 416-424

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensory incongruence leading to hand disownership modulates somatosensory cortical processing2014

    • Author(s)
      Otsuru N, Hoshizume A, Nakashima D, Endo Y, Inui K, Kakigi R, Yuge L
    • Journal Title

      Cortex

      Volume: 58 Pages: 1-8

    • Related Report
      2014 Annual Research Report
  • [Presentation] Removal of infected sten graft2016

    • Author(s)
      Sueda T
    • Organizer
      Japan Endovascular Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-08-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Spinal cord injur after thoracic endovascular aortic stent grafting2016

    • Author(s)
      Sueda T
    • Organizer
      American Association for Thoracic Surgery-Aortic Symposium-
    • Place of Presentation
      New York, USA
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胸部大動脈ステントグラフトのトラブル対処2015

    • Author(s)
      末田泰二郎
    • Organizer
      第10回日本endovascular symposium
    • Place of Presentation
      東京
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Endovascular repair for aortic arch pathology in elderly patients2015

    • Author(s)
      Taijiro Sueda
    • Organizer
      23th annual meeting of the Asian Society for Cardiovascular and Thoracic Surgery
    • Place of Presentation
      Hong Kong
    • Year and Date
      2015-05-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 新・心臓血管外科テキスト2016

    • Author(s)
      末田泰二郎、高橋信也
    • Publisher
      中外医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 日常診療に活かす診療ガイドラインup-to-date2016-20172016

    • Author(s)
      大毛宏喜、末田泰二郎
    • Publisher
      メデイカルレビュー社
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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