| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
The Biovalve preparation molds could be produced rapidly by using a 3D printing machine. Upon 2- month goat subcutaneous embedding aortic or pulmonary valve-shaped Biovalves were obtained from completely autologous connective tissue with collagen and fibroblasts. The three leaflet tissues were seamlessly connected with the surrounding conduit tissue, and showed homogeneous wall thickness and excellent mechanical strength that was equivalent to or more than that of the human pericardium, with individual or regional differences. As an aortic valve, in vitro evaluation of Biovalve showed excellent valvular functions. In a goat model, postoperative echocardiography after surgical replacement of the biovalves with stents showed smooth movement of the leaflets with little regurgitation under systemic circulation. In all implantation studies, the luminal surface after implantation was very smooth and fully covered with thin neointima, including endothelial cells without thrombus formation.
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