Development of autologous heart valves "biovalves" and their application to TAVI by combination of photomolding and in-body tissue architecture
| Project/Area Number |
26293314
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Nakayama Yasuhide 国立研究開発法人国立循環器病研究センター, その他部局等, その他 (50250262)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | バイオバルブ / 心臓弁 / 再生医療 / 生体内組織形成術 / 移植・再生医療 / 外科 / 細胞・組織 / 生体機能利用 / バイオリアクター |
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| Outline of Final Research Achievements |
The Biovalve preparation molds could be produced rapidly by using a 3D printing machine. Upon 2- month goat subcutaneous embedding aortic or pulmonary valve-shaped Biovalves were obtained from completely autologous connective tissue with collagen and fibroblasts. The three leaflet tissues were seamlessly connected with the surrounding conduit tissue, and showed homogeneous wall thickness and excellent mechanical strength that was equivalent to or more than that of the human pericardium, with individual or regional differences. As an aortic valve, in vitro evaluation of Biovalve showed excellent valvular functions. In a goat model, postoperative echocardiography after surgical replacement of the biovalves with stents showed smooth movement of the leaflets with little regurgitation under systemic circulation. In all implantation studies, the luminal surface after implantation was very smooth and fully covered with thin neointima, including endothelial cells without thrombus formation.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Successful implantation of autologous valved conduits with self-expanding stent (stent-biovalve) within the pulmonary artery in beagle dogs.2015
Author(s)
Funayama M, Matsui Y, Tajikawa T, Sasagawa T, Saito Y, Sagishima S, Mizuno T, Mizuno M, Harada K, Uchida S, Shinoda A, Iwai R, Nakayama Y, Uechi M.
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Journal Title
J Vet Cardiol.
Volume: 17(1)
Issue: 1
Pages: 54-61
DOI
Related Report
Peer Reviewed
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[Journal Article] In-body tissue engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding2014
Author(s)
Nakayama Y, Takewa Y, Sumukura H, Yamanami M, Matsui Y, Oie T, Kishimoto Y, Arakawa M, Ohnuma K, Kanda K, Tatsumi E
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: (in press)
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Development of In Vivo, Tissue-‐Engineered, Autologous, 3D Heart Valvular Tissue, Type SC Biovalve with Excellent Mechanical ProperFes, Valvular FuncFons, and In Vivo Performance2015
Author(s)
Nakayama Y, Talewa Y, Moriwaki T, Sumikura H, Funayama M, Furukoshi M, Tatsumi E, Miyamoto S, Okamoto K.
Organizer
American Heart Association Scientific Sesson 2015
Place of Presentation
Orlando, USA
Year and Date
2015-11-07
Related Report
Int'l Joint Research
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