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Cell-based therapy in lung regenerative medicine using adipose tissue-derived stem cell and induced pluripotent stem cell

Research Project

Project/Area Number 26293316
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionOsaka University

Principal Investigator

Okumura Meinoshin  大阪大学, 医学(系)研究科(研究院), 教授 (40252647)

Co-Investigator(Kenkyū-buntansha) 南 正人  大阪大学, 医学部附属病院, 准教授 (10240847)
井上 匡美  京都府立医科大学, 医学(系)研究科(研究院), 教授 (10379232)
川村 知裕  大阪大学, 医学(系)研究科(研究院), 助教 (30528675)
舟木 壮一郎  大阪大学, 医学(系)研究科(研究院), 助教 (50464251)
松浦 成昭  大阪大学, 医学(系)研究科(研究院), 特任教授 (70190402)
新谷 康  大阪大学, 医学(系)研究科(研究院), 准教授 (90572983)
中桐 伴行  大阪大学, 医学(系)研究科(研究院), 研究員 (70528710)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords肺再生 / 幹細胞 / 脂肪幹細胞 / 人工多機能性幹細胞 / 慢性閉塞性肺疾患 / iPS細胞 / アディポネクチン / 肺気腫 / HGF / PGI2
Outline of Final Research Achievements

Chronic obstructive pulmonary disease (COPD), a progressive lung disease. This study was designed to develop the therapeutic solution against COPD by the cell therapy.
We used the representative mice model of COPD. The adipose tissue-derived stem cell (ADSCs), , administered intravenously, and trans-bronchially. The ADSCs accumulated the damaged area and significantly inhibited deterioration of the lung compliance and histologic changes. We also focused on the induced pluripotent stem (iPS) cell as a source of supply of lung epithelial cell. To prepare the type2 alveolar cells, we investigated the general methods of differentiation the iPS cells. The differentiated iPS cells were transplanted into COPD model mice and improved lung function.Our data indicated that the administration of ADSCs and iPS cells improved the emphysema histologically and functionally.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (17 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice.2016

    • Author(s)
      Kimura T, Nojiri T, Hino J, Hosoda H, Miura K, Shintani Y, Inoue M, Zenitani M, Takabatake H, Miyazato M, Okumura M, Kangawa K.
    • Journal Title

      Respiratory research

      Volume: 17 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s12931-016-0335-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Carnosol Is a Potent Lung Protective Agent: Experimental Study on Mice.2015

    • Author(s)
      Kawamura T,Momozane T, Funaki S, Shintani Y, Inoue M, Minami M, Sugimura K, Iida O, Fuchino H, Kawahara N, Takemori H, Okumura M
    • Journal Title

      Transplant Procedings

      Volume: 47 Issue: 6 Pages: 1657-61

    • DOI

      10.1016/j.transproceed.2015.05.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-type natriuretic peptide attenuates lipopolysaccharide-induced acute lung injury in mice2015

    • Author(s)
      Kimura T, Nojiri T, Hosoda H, Ishikane S, Shintani Y, Inoue M, Miyazato M, Okumura M, Kangawa K
    • Journal Title

      J Surg Res

      Volume: 194 Issue: 2 Pages: 631-637

    • DOI

      10.1016/j.jss.2014.11.023

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective effects of C-type natriuretic peptide on cisplatin-induced nephrotoxicity in mice2015

    • Author(s)
      Kimura, T., Nojiri, T., Hosoda, H., Ishikane, S., Shintani, Y., Inoue, M., Miyazato, M., Okumura, M., Kangawa, K.
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: 75(5) Issue: 5 Pages: 1057-1063

    • DOI

      10.1007/s00280-015-2734-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exacerbation of bleomycin-induced injury by lipopolysaccharide in mice: establishment of a mouse model for acute exacerbation of interstitial lung diseases.2015

    • Author(s)
      Kimura T, Nojiri T, Hosoda H, Shintani Y, Inoue M, Miyazato M, Okumura M, Kangawa K.
    • Journal Title

      European journal of cardio-thoracic surgery

      Volume: 48 Issue: 4 Pages: e85-e91

    • DOI

      10.1093/ejcts/ezv261

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical usefulness of free subcutaneous fat pad for reduction of intraoperative air leakage during thoracoscopic pulmonary resection in lung cancer cases.2014

    • Author(s)
      Shintani Y, Inoue M, Funaki S, Kawamura T, Minami M, Okumura M.
    • Journal Title

      Surg Endosc.

      Volume: Epub

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury2014

    • Author(s)
      Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Kimura T, Shintani Y, Inoue M, Sawabata N, Miyazato M, Okumura M, Kangawa K
    • Journal Title

      Pulm Pharmacol Ther

      Volume: 29 Issue: 1 Pages: 24-30

    • DOI

      10.1016/j.pupt.2014.01.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 難治性肺疾患に対する肺再生治療2017

    • Author(s)
      舟木壮一郎、新谷康、川村知裕、神崎隆、南正人、酒井芳紀、宮川繁、澤芳樹、奥村明之進
    • Organizer
      第57回日本呼吸器学会総会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Year and Date
      2017-04-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 肺障害治癒過程における脂肪組織幹細胞の役割2017

    • Author(s)
      福井絵里子、新谷康、桃實徹、神崎隆、川村知裕、舟木壮一郎、南正人、奥村明之進
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 誘導型多能性幹細胞(iPS細胞)から肺上皮への分化誘導の検討2017

    • Author(s)
      桃實徹、新谷康、福井絵里子、神崎隆、川村知裕、舟木壮一郎、南正人、奥村明之進
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] C-type natriuretic peptide atteuates bleomycin-induced fibrosis and inflammation in murine lung2015

    • Author(s)
      Kimura T,Nojiri T, Hosoda H, Shintani Y, Inoue M, Miyazato M, Okumura M, Kangawa K
    • Organizer
      16th World Conference on Lung Cancer
    • Place of Presentation
      Denver,United States of America
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CNP attenuates renal toxicity induced by cisplatin in murine kidney2015

    • Author(s)
      Kimura T,Nojiri T, Hosoda H, Miyazato M, Kangawa K
    • Organizer
      International Conference on cGMP(7)
    • Place of Presentation
      Trier,the Federal Republic of Germany
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of a new mouse model for postoperative acute exacerbation in interstitial lung diseases2015

    • Author(s)
      Kimura T,Nojiri T, Hosoda H, Shintani Y, Inoue M, Miyazato M, Okumura M, Kangawa K
    • Organizer
      European Conference on General Thoracic Surgery(32)
    • Place of Presentation
      Lisbon,Portuguese Republic
    • Year and Date
      2015-05-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] C-type natriuretic peptide atteuates acute and chronic inflammatory reactions in murine lung2015

    • Author(s)
      Kimura T
    • Organizer
      Thoracic Surgery Seminar in Kyoto
    • Place of Presentation
      京都
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] プロスタサイクリンアゴニストONO-1301による肺再生治療の可能性2015

    • Author(s)
      舟木壮一郎、新谷 康、奥村明之進、ほか
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sustained-release delivery of prostacyclin analogue(ONO-1301) enhances lung regeneration after pnuemonectomy in mice.2014

    • Author(s)
      Funaki S, Shintani Y, Kawamura T, Nakagiri T, Inoue M, Sawabata N, Minami M, Kimura A, Sakai Y, Miyagawa S, Sawa Y, Okumura M
    • Organizer
      American thoracic society Interenational conference
    • Place of Presentation
      San Diego,United States of America
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Book] 先進医療NAVIGATOR 今日の再生医療2016

    • Author(s)
      新谷康
    • Total Pages
      4
    • Publisher
      日本医学出版
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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