Research for improvement of local CNS drug delivery system and its generalization
| Project/Area Number |
26293319
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
Saito Ryuta 東北大学, 大学病院, 助教 (10400243)
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| Co-Investigator(Kenkyū-buntansha) |
冨永 悌二 東北大学, 医学(系)研究科(研究院), 教授 (00217548)
芳賀 洋一 東北大学, その他の研究科, 教授 (00282096)
荒井 啓行 東北大学, 加齢医学研究所, 教授 (30261613)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 薬剤送達 / 中枢神経系 / 脳腫瘍 / アルツハイマー病 / てんかん / アルツハイマー |
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| Outline of Final Research Achievements |
Recently, we have been working towards CNS (central nervous system) drug delivery system that enables effective distribution of the infusate. Aiming at improved and stable drug delivery system, we developed ultrasound facilitated drug delivery (UFD) device that achieve improved distribution in brain parenchyma. In this study, in order to improve the system, we developed pressure-controlled microinfusion pump. We demonstrated that our system enabled constant pressure delivery within +/- 1mmHg pressure range. Second generation UFD device was also fabricated for stable delivery. Subsequently, to prove that our device is applicable to multiple CNS diseases, we attempted to deliver therapeutic agents to epilepsy model, spinal disease model, and Alzheimer disease model. Anti-epileptic agents worked in epilepsy model, chemotherapeutic drug worked in spinal tumor model. Both of these headed for publication of the literature.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Intraparenchymal ultrasound application and improved distribution of infusate with convection-enhanced delivery in rodent and nonhuman primate brain.2016
Author(s)
Mano Y, Saito R, Haga Y, Matsunaga T, Zhang R, Chonan M, Haryu S, Shoji T, Sato A, Sonoda Y, Tsuruoka N, Nishiyachi K, Sumiyoshi A, Nonaka H, Kawashima R, Tominaga T.
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Journal Title
J Neurosurg.
Volume: 124(5)
Issue: 5
Pages: 1490-500
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intraparenchymal ultrasound application improve the distribution of convection-enhanced delivery in rodents’ and non-human primates’ brain2015
Author(s)
Yui Mano, Ryuta Saito, Yoichi Haga, Tadao Matsunaga, Rong Zhang, M.D., Chonan Masashi, Shinya Haryu, Takuhiro Shoji, Aya Sato, Yukihiko Sonoda, Noriko Tsuruoka, Keisuke Nishiyachi, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima, Teiji Tominaga
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Journal Title
Journal of Neurosurgery
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Patent(Industrial Property Rights)] 薬液注入装置2016
Inventor(s)
冨永悌二、齋藤竜太、佐藤綾耶、他8名
Industrial Property Rights Holder
冨永悌二、齋藤竜太、佐藤綾耶、他8名
Industrial Property Rights Type
特許
Industrial Property Number
2016-111559
Filing Date
2016-06-03
Related Report
