The fundamental and preclinical study about accelerator-based boron neutron capture therapy in hospital
| Project/Area Number |
26293320
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Matsumura Akira 筑波大学, 医学医療系(副学長), 副学長 (90241819)
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| Co-Investigator(Kenkyū-buntansha) |
熊田 博明 筑波大学, 医学医療系, 准教授 (30354913)
山本 哲哉 横浜市立大学, 医学部, 教授 (30375505)
中井 啓 茨城県立医療大学, 公私立大学の部局等, 准教授 (50436284)
磯辺 智範 筑波大学, 医学医療系, 教授 (70383643)
鶴淵 隆夫 筑波大学, 医学医療系, 講師 (70778901)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 中性子捕捉療法 / 病院内小型加速器 / 治療計画システム / 生物学的基礎実験 / 加速器 / モンテカルロ / 線量評価 / 細胞照射実験 / 脳腫瘍学 / 粒子線治療 / ホウ素中性子捕捉療法 / 加速器中性子線源 / 悪性脳腫瘍 / ホウ素中性子補足療法 |
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| Outline of Final Research Achievements |
To establish neutron capture therapy as medical treatment, we conducted fundamental studies with the paradigm shift in the nuclear source development from the nuclear reactor to a small accelerator suitable for placement in a hospital. It took a large amount of time to develop and verify power supply and cooling devices, a neutron generating target, etc. to raise the output of a small accelerator, and in the end of the 2017 fiscal year it was near completion. We also developed various peripheral devices. For dosimetry and neutron spectrum calculation, we established and verified an original treatment planning system called ‘TSUKUBA PLAN’ based on an original protocol using Monte Carlo simulation. We also conducted biological basic experiments on the uptake of boron compounds by tumor stem cells. It was found that tumor stem cells go through the cell cycle more slowly than tumor cells and tumorigenesis increases the uptake of 18F-BPA tumor cells with the faster cell cycle.
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Report
(5 results)
Research Products
(44 results)
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[Journal Article] BORON-NEUTRON CAPTURE THERAPY IN RUSSIA: PRECLINICAL EVALUATION OF EFFICACY AND PERSPECTIVES OF ITS APPLICATION IN NEURO-ONCOLOGY2017
Author(s)
Zaboronok AA, Byvaltsev VA, Kanygin VV, Iarullina A.I., Kichigin A.I.2,4,Taranin AV, Volkova OYu, Mechetina LV, Taskaev SYu, Muhamadiyarov RA,Zavyalov EL, Nakai K, Sato E, Yamamoto T, Mathis BJ, Matsumura A
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Journal Title
THE NEW ARMENIAN MEDICAL JOURNAL
Volume: 11,1
Pages: 6-15
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Accelerator-based neutron capture therapy: in-vitro efficacy evaluation and in-sample dosimetry using gold nanoparticles2017
Author(s)
Zaboronok A, Taskaev S, Volkova O, Mechetina L, Sato E, Nakai K, Yamamoto T, Taranin A, Kanygin V, Mathis BJ, Matsumura A
Organizer
9th young researchers’ BNCT meeting
Related Report
Int'l Joint Research
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[Presentation] Accelerator-based boron neutron capture therapy for malignant glioma: neutron dose evaluation with gold nanoparticles.2016
Author(s)
Zaboronok A, Taskaev S, Kasatov D, Makarov A, Schudlo I, Sorokin I, Sycheva T, Volkova O, Mechetina L, Taranin A, Kanygin V, Byvaltsev V, Iarullina A, Nakai K, Sato E, Yamamoto T, Matsumura A
Organizer
The 5th Russian-Japanese Neurosurgical Symposium
Place of Presentation
Kazan, Russia
Year and Date
2016-06-22
Related Report
Int'l Joint Research
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[Presentation] 筑波大学における頭頸部BNCT臨床研究経過報告2015
Author(s)
粟飯原 輝人,石川 仁, 和田 哲郎, 福光 延吉, 大西 かよ子, 中井 啓, 長谷川 正午, 硲田 猛真, 中山 雅博, 田渕 経司, 奥村 敏之, 鈴木 実, 原 晃, 櫻井 英幸
Organizer
第３９回頭頸部癌学会
Place of Presentation
神戸 神戸国際会議場
Year and Date
2015-06-04
Related Report
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