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Mechanistic insight into malignant transformation and therapeutic strategies based on the comparative multi-omics analysis of primary and recurrent gliomas

Research Project

Project/Area Number 26293321
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKumamoto University (2017)
The University of Tokyo (2014-2016)

Principal Investigator

Mukasa Akitake  熊本大学, 大学院生命科学研究部(医), 教授 (90463869)

Co-Investigator(Kenkyū-buntansha) 田中 將太  東京大学, 医学部附属病院, 助教 (80643725)
Co-Investigator(Renkei-kenkyūsha) SAITO Kuniaki  杏林大学, 医学部, 助教 (50446564)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords悪性神経膠腫 / ゲノム / エピゲノム / 腫瘍内多様性 / 治療抵抗性
Outline of Final Research Achievements

To understand the changes of the molecular profile during tumor progression and to develop a proper treatment strategy, multi “omics” analysis was performed in approximately 122 gliomas that includes 22 paired samples of primary and recurrent tumors with exome sequencing and RNA-sequencing, as well as Infinium 450K methylation chip. The integrated bioinformatics analysis revealed that a large proportion of recurrent tumors had markedly different set of mutations and showed branched evolution pattern. Some malignantly transformed diffuse astrocytomas previously treated by temozolomide acquired numerous de novo mutations accompanying mutations in mismatch repair genes and showed a “hypermutator phenotype”. Genome-wide DNA methylation analysis revealed characteristic DNA demethylation during malignant progression in a subset diffuse astrocytomas. Interestingly, we found that most loci that were demethylated during malignant progression were located outside of CpG islands.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (56 results)

All 2018 2017 2016 2015 2014

All Journal Article (23 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 20 results,  Open Access: 13 results,  Acknowledgement Compliant: 2 results) Presentation (30 results) (of which Int'l Joint Research: 8 results,  Invited: 18 results) Book (3 results)

  • [Journal Article] Clinical significance of polyglutamylation in primary central nervous system lymphoma2018

    • Author(s)
      Shinojima Naoki、Fujimoto Kenji、Makino Keishi、Todaka Kohei、Yamada Kazumichi、Mikami Yoshiki、Oda Kazutaka、Nakamura Kazumi、Jono Hirofumi、Kuratsu Jun-ichi、Nakamura Hideo、Yano Shigetoshi、Mukasa Akitake
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 6 Issue: 1 Pages: 15-15

    • DOI

      10.1186/s40478-018-0522-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 神経膠腫の不均一性による治療抵抗性とその治療戦略2018

    • Author(s)
      武笠 晃丈
    • Journal Title

      実験医学

      Volume: 36 Pages: 307-313

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Genome-wide DNA methylation profiles identifies primary central nervous system lymphomas as a distinct entity from systemic diffuse large B-cell lymphomas2017

    • Author(s)
      Nakamura T, Yamashita S, Fukumura K, Tanaka K, Nagane M, Narita Y, Mano H, Ushijima T, Ichimura K
    • Journal Title

      Acta Neuropathol

      Volume: 133 Issue: 2 Pages: 321-324

    • DOI

      10.1007/s00401-016-1664-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An automated voxel-based method for calculating the reference value for a brain tumour metabolic index using 18F-FDG PET and 11C-Methionine PET.2017

    • Author(s)
      Takahashi, Soma T, Mukasa A, Koyama, Arai T, Momose T.
    • Journal Title

      Ann Nucl Med

      Volume: 31 Issue: 3 Pages: 250-259

    • DOI

      10.1007/s12149-017-1153-8

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.2017

    • Author(s)
      Takayanagi S, Mukasa A, Tanaka S, Nomura M, Omata M, Yanagisawa S, Yamamoto S, Ichimura K, Nakatomi H, Ueki K, Aburatani H, Saito N
    • Journal Title

      Neuro Oncol.

      Volume: 印刷中 Issue: 9 Pages: 1-7

    • DOI

      10.1093/neuonc/nox034

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brachyury gene copy number gain and activation of the PI3K/Akt pathway: Association with upregulation of oncogenic Brachyury expression in skull base chordoma2017

    • Author(s)
      Otani Ryohei、Mukasa Akitake、Shin Masahiro、Omata Mayu、Takayanagi Shunsaku、Tanaka Shota、Ueki Keisuke、Saito Nobuhito
    • Journal Title

      Journal of Neurosurgery

      Volume: 128 Issue: 5 Pages: 1428

    • DOI

      10.3171/2016.12.jns161444

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct molecular profile of diffuse cerebellar gliomas2017

    • Author(s)
      Nomura M, Mukasa A, Nagae G, Yamamoto S, Tatsuno K, Ueda H, Fukuda S, Umeda T, Suzuki T, Otani R, Kobayashi K, Maruyama T, Tanaka S, Takayanagi S, Nejo T, Takahashi S, Ichimura K, Nakamura T, Muragaki Y, Narita Y, Nagane M, Ueki K, Nishikawa R, Shibahara J, Aburatani H, Saito N
    • Journal Title

      Acta Neuropathologica

      Volume: 134 Issue: 6 Pages: 941-956

    • DOI

      10.1007/s00401-017-1771-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a novel fusion gene HMGA2-EGFR in glioblastoma2017

    • Author(s)
      Komuro Akiyoshi、Raja Erna、Iwata Caname、Soda Manabu、Isogaya Kazunobu、Yuki Keiko、Ino Yasushi、Morikawa Masato、Todo Tomoki、Aburatani Hiroyuki、Suzuki Hiromichi、Ranjit Melissa、Natsume Atsushi、Mukasa Akitake、Saito Nobuhito、Okada Hitoshi、Mano Hiroyuki、Miyazono Kohei、Koinuma Daizo
    • Journal Title

      International Journal of Cancer

      Volume: 142 Issue: 8 Pages: 1627

    • DOI

      10.1002/ijc.31179

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation2017

    • Author(s)
      Takai Keisuke、Tanaka Shota、Sota Takashi、Mukasa Akitake、Komori Takashi、Taniguchi Makoto
    • Journal Title

      World Neurosurgery

      Volume: 108 Pages: 991.e13-991.e16

    • DOI

      10.1016/j.wneu.2017.08.142

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack2017

    • Author(s)
      Yoshida Y, Wang H, Hiwasa T, Machida T, Takiguchi M, Iwadate Y, et al.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 3 Pages: 8836-8848

    • DOI

      10.1007/s11060-018-2831-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The significance of histone H3 K27M mutation in brain tumors2017

    • Author(s)
      武笠 晃丈
    • Journal Title

      Progress in Neuro-Oncology

      Volume: 24 Issue: 1 Pages: 7-17

    • DOI

      10.11452/neurooncology.24.1_7

    • NAID

      130005868650

    • ISSN
      1880-0742, 2187-0551
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and epigenetic stability of oligodendrogliomas at recurrence.2017

    • Author(s)
      Aihara K, Mukasa A, Nagae G, Nomura M, Yamamoto S, Ueda H, Tatsuno K, Shibahara J, Takahashi M, Momose T, Tanaka S, Takayanagi S, Yanagisawa S, Nejo T, Takahashi S, Omata M, Otani R, Saito K, Narita Y, Nagane M, Nishikawa R, Ueki K, Aburatani H, Saito N
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 5 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s40478-017-0422-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis2016

    • Author(s)
      Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, K, Houkin K, Terasaka S, Tabei Y, Nakamura H, Nagane M, Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu T, Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Naakagawa Y, Miyatake S.
    • Journal Title

      Neuro-Oncology Practice

      Volume: 0 Issue: 4 Pages: 1-9

    • DOI

      10.1093/nop/npv064

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas2016

    • Author(s)
      Arita H, Yamasaki K, Matsushita Y, Nakamura T, Shimokawa A, Takami H, Tanaka S, Mukasa A, Shirahata M, Shimizu S, Suzuki K, Saito K, Kobayashi K, Higuchi F, Uzuka T, Otani R, Tamura K, Sumita K, Ohno M, Miyakita Y, Kagawa N, Hashimoto N, Hatae R, Yoshimoto K, Shinojima N, Nakamura H, Kanemura Y, Okita Y, et al.
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 4 Issue: 1 Pages: 79

    • DOI

      10.1186/s40478-016-0351-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma2016

    • Author(s)
      Nagashima H, Tanaka K, Sasayama T, Irino Y, Sato N, Takeuchi Y, Kyotani K, Mukasa A, Mizukawa K, Sakata J, Yamamoto Y, Hosoda K, Itoh T, Sasaki R, Kohmura E.
    • Journal Title

      Neuro Oncol

      Volume: 18(11) Pages: 1559-1568

    • DOI

      10.1093/neuonc/now090

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas.2016

    • Author(s)
      Ikemura M, Shibahara J, Mukasa A, Takayanagi S, Aihara K, Saito N, Aburatani H, Fukayama M.
    • Journal Title

      Histopathology

      Volume: 印刷中 Issue: 2 Pages: 260-267

    • DOI

      10.1111/his.12927

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic characterization of primary central nervous system lymphoma.2016

    • Author(s)
      Fukumura K, Kawazu M, Kojima S, Ueno T, Sai E, Soda M, Ueda H, Yasuda T, Yamaguchi H, Lee J, Shishido-Hara Y, Sasaki A, Shirahata M, Mishima K, Ichimura K, Mukasa A, Narita Y, Saito N, Aburatani H, Nishikawa R, Nagane M, Mano H
    • Journal Title

      Acta Neuropathol

      Volume: Epub

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Findings from positron emission tomography and genetic analyses for cerebellar liponeurocytoma.2015

    • Author(s)
      Takami H, Mukasa A, Ikemura M, Shibahara J, Takahashi M, Momose T, Saito N.
    • Journal Title

      Brain Tumor Pathol

      Volume: 32 Issue: 3 Pages: 210-215

    • DOI

      10.1007/s10014-014-0210-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment.2015

    • Author(s)
      van Thuijl HF, Mazor T, Johnson BE, Fouse SD, Aihara K, Hong C, Malmström A, Hallbeck M, Heimans JJ, Kloezeman JJ, Stenmark-Askmalm M, Lamfers ML, Saito N, Aburatani H, Mukasa A, Berger MS, Söderkvist P, Taylor BS, Molinaro AM, Wesseling P, Reijneveld JC, Chang SM, Ylstra B, Costello JF
    • Journal Title

      Acta Neuropathol.

      Volume: 129 Issue: 4 Pages: 597-607

    • DOI

      10.1007/s00401-015-1403-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-Methylosome complex2014

    • Author(s)
      Hiroki Takai, Tetsu Akiyama et al.
    • Journal Title

      Cell Reports

      Volume: 9 Issue: 1 Pages: 48

    • DOI

      10.1016/j.celrep.2014.08.071

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas.2014

    • Author(s)
      Fukushima S, Otsuka A, Suzuki T, Yanagisawa T, Mishima K. et al.
    • Journal Title

      Acta Neuropatholgica

      Volume: 127 Issue: 6 Pages: 911-925

    • DOI

      10.1007/s00401-014-1247-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] がんゲノムの多様性解析と治療への展開2014

    • Author(s)
      武笠晃丈
    • Journal Title

      実験医学

      Volume: 32 Pages: 1928-1935

    • Related Report
      2014 Annual Research Report
  • [Journal Article] がんの進展・治療に伴うゲノム変化2014

    • Author(s)
      武笠晃丈
    • Journal Title

      医学のあゆみ

      Volume: 249 Pages: 1099-1104

    • Related Report
      2014 Annual Research Report
  • [Presentation] The characteristics of molecular profile changes in recurrent lower grade gliomas and their implication for therapeutic strategy2017

    • Author(s)
      Akitake Mukasa, Kuniaki Saito, Shota Tanaka, Shunsaku Takayanagi,Yoshitaka Narita, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      5th Quadrennial Meeting of the World Federation of Neuro-Oncology Societies
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spatial Heterogeneity of Molecular Profiles in Gliomas and its Implications for Cell-of-Origin and Targeted Therapy2017

    • Author(s)
      Akitake Mukasa
    • Organizer
      The 72nd Fujihara Seminar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Genetic and epigenetic stability of oligodendrogliomas at recurrence2017

    • Author(s)
      Akitake Mukasa, Koki Aihara, Masashi Nomura, Shota Tanaka, Junji Shibahara, Yoshitaka Narita, Motoo Nagane, Ryo Nishikawa, Keisuke Ueki, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      The 14th Meeting of the Asian Society for Neuro-Oncology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristic molecular profile changes in primary and recurrent gliomas depending on their histopathology2017

    • Author(s)
      Akitake Mukasa, Masashi Nomura, Kuniaki Saito, Koki Aihara, Genta Nagae, Takahide Nejo, Shota Tanaka, Shunsaku Takayanagi, Satoshi Takahashi, Mayu Omata, Taishi Nakamura, Yoshitaka Narita, Yoshihiro Muragaki, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      22nd Annual Meeting of the Society of Neuro-Oncology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 再発 oligodendroglioma の ゲノム・エピゲノムの安定性2017

    • Author(s)
      武笠晃丈、相原功輝、野村昌志、田中將太、高柳俊作、永根基雄、成田善孝、植木敬介、油谷浩幸、斉藤延人
    • Organizer
      第34回日本脳腫瘍病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Integrated and comparative multi-omics analysis of primary and recurrent glioma and its clinical application2017

    • Author(s)
      Akitake Mukasa, Masashi Nomura, Kuniaki Saito, Koki Aihara, Genta Nagae, Takahide Nejo, Shunsaku Takayanagi, Shota Tanaka, Taishi Nakamura, Yoshitaka Narita, Yoshihiro Muragaki, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      第76回日本脳神経外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 初発・再発神経膠腫のマルチオミクス比較解析から考える悪性転化機序とその治療戦略2017

    • Author(s)
      武笠晃丈、野村昌志、齊藤邦昭、相原功輝、永江玄太、上田 宏生、山本 尚吾、辰野 健二、根城 尭英、高橋 慧、高柳俊作、田中將太、花 大洵、北川陽介、中村大志、成田善孝、村垣善浩、永根基雄、西川 亮、植木敬介、油谷浩幸、斉藤延人
    • Organizer
      第35日本脳腫瘍学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遺伝子プロファイル解析から考える神経膠腫の診断と治療戦略2016

    • Author(s)
      武笠晃丈
    • Organizer
      Temozolomide Forum in HIROSHIMA 2016
    • Place of Presentation
      リーガロイヤルホテル広島(広島県・広島市)
    • Year and Date
      2016-12-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Molecular pathological analysis on IDH-wildtype adult low-grade gliomas2016

    • Author(s)
      Akitake Mukasa, Koki Aihara, Genta Nagae, Junji Shibahara, Shota Tanaka, Shunsaku Takayanagi, Masashi Nomura, Motoo Nagane, Yoshitaka Narita, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      21th Annual Meeting of the Society of Neuro-Oncology
    • Place of Presentation
      Farimont Scottsdate Princess Hotel (Scottsdale, Arizona, USA)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influence of anticancer therapy on clonal evolution and intratumoral heterogeneity of gliomas2016

    • Author(s)
      Akitake Mukasa
    • Organizer
      75rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 再発神経膠腫の分子遺伝学的変化に基づく治療戦略の構築2016

    • Author(s)
      武笠晃丈、相原功輝、齊藤邦昭、永江玄太、野村昌志、根城 尭英、高柳俊作、田中將太、柳澤 俊介、高橋 慧、西川亮、永根基雄、成田善孝、植木敬介、油谷浩幸、斉藤延人
    • Organizer
      第75回日本脳神経外科学会
    • Place of Presentation
      福岡国際会議(福岡県・福岡市)
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] グリオーマのゲノム多様性とクローン進化に及ぼす抗がん治療の影響2016

    • Author(s)
      武笠晃丈
    • Organizer
      第21回脳腫瘍の外科学会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都・港区)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] マルチオミクス解析からみたグリオーマの多様性とその治療における意義2016

    • Author(s)
      武笠晃丈
    • Organizer
      先端脳腫瘍治療シンポジウム 2016
    • Place of Presentation
      MSD株式会社 仙台事務所(宮城県・仙台市)
    • Year and Date
      2016-06-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A multidisciplinary approach to the treatment of brain tumor.2016

    • Author(s)
      武笠晃丈, 斉藤延人
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Genome-wide methylation analysis identifies genomic DNA demethylation during malignant progression of gliomas2016

    • Author(s)
      Akitake Mukasa, Kuniaki Saito, Koki Aihara, Genta Nagae, Shota Tanaka, Yoshitaka Narit, Keisuke Ueki, Ryo Nishikawa, Motoo Nagane, Hiroyuki Aburatani, Nobuhito Saito.
    • Organizer
      21st International Conference on Brain Tumor Research and Therapy
    • Place of Presentation
      万国津梁館(沖縄県・名護市)
    • Year and Date
      2016-04-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 9.IDH遺伝子変異を有さない成人びまん性低悪性度神経膠腫の分子病理学的解析2015

    • Author(s)
      武笠晃丈、相原功輝、高柳俊作、田中將太、野村昌志、柳澤俊介、永江玄太、上田宏生、山本尚吾、辰野健二、白畑充章、植木敬介、永根基雄、成田善孝、市村幸一、柴原純二、小森隆司、西川 亮、油谷浩幸、斉藤延人
    • Organizer
      第33回日本脳腫瘍学会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経膠腫の悪性化とケノム進化一新たな治療法開発へ2015

    • Author(s)
      武笠晃丈
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 神経膠腫の時間的・空間的な多様性からみた治療戦略の展望2015

    • Author(s)
      武笠晃丈
    • Organizer
      第74回日本脳神経外科学会
    • Place of Presentation
      札幌市
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] グリオーマの遺伝子診断と治療戦略2015

    • Author(s)
      武笠晃丈
    • Organizer
      第16回日本分子脳神経外科学会
    • Place of Presentation
      浜松市
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Clonal Evolution and Intratumoral Heterogeneity of Glioma2015

    • Author(s)
      Akitake Mukasa
    • Organizer
      The 1st TGU Medical Symposium of The University of Chicago The University of Tokyo
    • Place of Presentation
      東京
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ゲノム解析から考える低悪性度神経膠腫の治療戦略の問題点2015

    • Author(s)
      武笠晃丈
    • Organizer
      第29回東京脳腫瘍治療懇話会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] DNA methylation profile analysis of gliomas revealed a change in methylation status during malignant progression2015

    • Author(s)
      Akitake Mukasa, Kuniaki Saito, Koki Aihara, Genta Nagae, Mayu Omata, Rhyohei Otani, Shunsaku Takayanagi, Shota Tanaka, Yoshitaka Narita, Yoshitaka Narita, Keisuke Ueki, Ryo Nishikawa, Motoo Nagane, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      American Association for Cancer Research(AACR) Annual Meeting 2015
    • Place of Presentation
      Philadelphia
    • Year and Date
      2015-04-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経膠腫悪性転化症例のオミクス解析から考える個別化治療戦略2014

    • Author(s)
      武笠 晃丈、齊藤 邦昭、相原 功輝、永江 玄太、Johnson BE、高柳 俊作、大谷 亮平、田中 將太、柳澤 俊介、上田 宏生、山本 尚吾、辰野 健二、Costello JF、西川 亮、永根 基雄、成田 善孝、植木 敬介、油谷 浩幸、斉藤 延人
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      浦安
    • Year and Date
      2014-11-30 – 2014-12-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] グリオーマの発生・進展にかかわるエピゲノム異常2014

    • Author(s)
      武笠 晃丈
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] グリオーマの腫瘍内多様性に及ぼす抗がん治療の影響2014

    • Author(s)
      武笠 晃丈
    • Organizer
      第87回日本生化学大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 化学療法剤による神経膠腫ゲノム不安定性の加速の可能性2014

    • Author(s)
      武笠 晃丈、相原 功輝、齊藤 邦昭、Johnson BE、高柳 俊作、上田 宏生、山本 尚吾、辰野 健二、永江 玄太、成田 善孝、永根 基雄、西川 亮、植木 敬介、Costello JF、油谷 浩幸、斉藤 延人
    • Organizer
      第73回日本脳神経外科学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clonal evolution of glioma induced by anti-cancer therapy2014

    • Author(s)
      武笠 晃丈
    • Organizer
      第73回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] グリオーマゲノム解析がもたらす治療戦略構築へのヒント2014

    • Author(s)
      武笠 晃丈
    • Organizer
      第19回 北海道脳腫瘍治療研究会
    • Place of Presentation
      札幌
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 化学療法がもたらすがんゲノム不安定性の加速2014

    • Author(s)
      武笠 晃丈
    • Organizer
      第18回 日本がん分子標的治療学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-26 – 2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ゲノム解析により明らかとなる神経膠腫の多様性と、その治療・悪性化にかかわる問題点2014

    • Author(s)
      武笠 晃丈
    • Organizer
      第9回 脳腫瘍の基礎シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] 脳腫瘍取扱い規約 第4版2018

    • Author(s)
      日本脳神経外科学会、日本病理学会 分担執筆
    • Total Pages
      250
    • Publisher
      金原出版
    • ISBN
      4307203852
    • Related Report
      2017 Annual Research Report
  • [Book] 上衣系腫瘍, グリオーマ治療のDecision Making 脳神経外科診療プラクティス2016

    • Author(s)
      武笠晃丈
    • Total Pages
      4
    • Publisher
      文光堂
    • Related Report
      2016 Annual Research Report
  • [Book] 脳腫瘍の部位別発症頻度と問題点, 脳腫瘍学 日本臨床 2016年9月増刊号2016

    • Author(s)
      武笠晃丈、田中將太、斉藤延人
    • Total Pages
      5
    • Publisher
      日本臨床社
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2019-12-27  

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