Research for risk factors and potential therapeutic targets of musculoskeletal disorders caused by spinal disease and comorbidities
Project/Area Number |
26293329
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | National Rehabilitation Center for Persons with Disabilities |
Principal Investigator |
AKUNE Toru 国立障害者リハビリテーションセンター(研究所), 病院(併任研究所), 副院長 (60282662)
|
Co-Investigator(Kenkyū-buntansha) |
村木 重之 東京大学, 医学部附属病院, 登録研究員 (40401070)
吉村 典子 東京大学, 医学部附属病院, 特任教授 (60240355)
岡 敬之 東京大学, 医学部附属病院, 特任准教授 (60401064)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 医療・福祉 |
Outline of Final Research Achievements |
This study investigated epidemiologic evidence of spinal diseases and comorbidities using database of the ROAD (Research on Osteoarthritis/ osteoporosis Against Disability) and the Wakayama Spine Study. Data collection of musculoskeletal diseases and disorders including spinal diseases in population-based cohort of Japanese men and women was performed in the ROAD cohort and the Wakayama Spine Study cohort, which was a sub-cohort of the ROAD. Prevalence of cervical myelopathy, diffuse idiopathic skeletal hyperostosis, lumbar disc degeneration, tandem spinal stenosis, and acetabular dysplasia was examined, and association of pain and indices of spinal diseases and comorbidities was investigated and reported. Further, incidence and risk factors of lumbar spondylosis, lumbar disc degeneration, sarcopenia, and certified need of care in the long-term care insurance system was investigated and reported.
|
Report
(5 results)
Research Products
(61 results)
-
[Journal Article] Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study.2018
Author(s)
Kodama R, Muraki S, Iidaka T, Oka H, Teraguchi M, Kagotani R, Asai Y, Hashizume H, Yoshida M, Kawaguchi H, Nakamura K, Akune T, Tanaka S, Yoshimura N.
-
Journal Title
J Bone Miner Metab
Volume: 36
Pages: 246-253
DOI
Related Report
Peer Reviewed
-
[Journal Article] Association of Lumbar Spondylolisthesis With Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study.2017
Author(s)
Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
-
Journal Title
Spine(Phila Pa 1976)
Volume: 42
Pages: E666-E671
DOI
Related Report
Peer Reviewed
-
[Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study.2017
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Yamada H, Oka H, Minamide A, Nagata K, Ishimoto Y, Kagotani R, Kawaguchi H, Tanaka S, Akune T, Nakamura K, Muraki S,Yoshida M.
-
Journal Title
Osteoarthritis Cartilage
Volume: 25
Pages: 1122-1131
DOI
Related Report
Peer Reviewed
-
[Journal Article] The prevalence of tandem spinal stenosis and its characteristics in a population-based MRI study: The2017
Author(s)
Nagata K, Yoshimura N, Hashizume H, Ishimoto Y, Muraki S, Yamada H, Oka H, Kawaguchi H, Akune T, Tanaka S, Nakamura K, Yoshida M.
-
Journal Title
Eur Spine J
Volume: 26
Pages: 2529-2535
DOI
Related Report
Peer Reviewed
-
[Journal Article] Sagittal spino-pelvic alignment in adults: The Wakayama Spine Study.2017
Author(s)
Asai Y, Tsutsui S, Oka H, Yoshimura N, Hashizume H, Yamada H, Akune T, Muraki S, Matsudaira K, Kawaguchi H, Nakamura K, Tanaka S, Yoshida M.
-
Journal Title
PLoS One
Volume: 12
Pages: e0178697
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] MRI-defined paraspinal muscle morphology in Japanese population: The Wakayama Spine Study.2017
Author(s)
Sasaki T, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Iwahashi H, Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M.
-
Journal Title
PLoS One
Volume: 12
Pages: e0187765
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study.2016
Author(s)
Kodama R, Muraki S, Oka H, Iidaka T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Morizaki Y, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshimura N.
-
Journal Title
Mod Rheumatol
Volume: 26
Pages: 767-773
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] The Association between the Cross-Sectional Area of the Dural Sac and Low Back Pain in a Large Population: The Wakayama Spine Study.2016
Author(s)
Iwahashi H, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M.
-
Journal Title
PLoS One
Volume: 11
Pages: e0160002
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Classification of High Intensity Zones of the Lumbar Spine and Their Association with Other Spinal MRI Phenotypes: The Wakayama Spine Study.2016
Author(s)
Teraguchi M, Samartzis D, Hashizume H, Yamada H, Muraki S, Oka H, Cheung JP, Kagotani R, Iwahashi H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Cheung KM, Yoshimura N, Yoshida M.
-
Journal Title
PLoS One
Volume: 11
Pages: e0160111
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study.2016
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
-
Journal Title
PLoS One
Volume: 11
Pages: e0147565
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] The association of combination of disc degeneration, end plate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study.2015
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Nakagawa H, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
-
Journal Title
Spine J
Volume: 15
Pages: 622-628
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: the ROAD study.2015
Author(s)
Muraki S, Akune T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N.
-
Journal Title
BMC Musculoskelet Disord
Volume: 16
Pages: 305
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Joint space narrowing, body mass index, and knee pain: the ROAD study.2015
Author(s)
Muraki S, Akune T, En-Yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Tanaka S, Nakamura K, Kawaguchi H, Oka H, Yoshimura N.
-
Journal Title
Osteoarthritis Cartilage
Volume: 23
Pages: 874-881
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Does osteophytosis at the knee predict health-related quality of life decline? A 3-year follow-up of the ROAD study.2015
Author(s)
Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N.
-
Journal Title
Clin Rheumatol.
Volume: 34
Pages: 1589-1597
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
[Journal Article] Incidence of disability and its associated factors in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study.2015
Author(s)
Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
-
Journal Title
J Bone Miner Metab
Volume: 33
Pages: 186-191
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study.2015
Author(s)
Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
-
Journal Title
J Bone Miner Metab
Volume: 33
Pages: 221-229
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based magnetic resonance imaging study: the Wakayama Spine Study.2014
Author(s)
Nagata K, Yoshimura N, Hashizume H, Muraki S, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
-
Journal Title
Spine J
Volume: 14
Pages: 2811-2817
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: the ROAD study.2014
Author(s)
Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N.
-
Journal Title
Mod Rheumatol.
Volume: 24
Pages: 966-973
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
[Journal Article] Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study.2014
Author(s)
Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
-
Journal Title
J Bone Miner Metab
Volume: 32
Pages: 524-532
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
[Presentation] 椎間板変性と再生医療 一般住民コホートにおけるTHBS2と椎間板変性との相関解析2017
Author(s)
出口 剛士, 橋爪 洋, 中島 正宏, 寺口 真年, 阿久根 徹, 山田 宏, 田中 栄, 吉村 典子, 野島 正寛, 池川 志郎, 吉田 宗人
Organizer
第32回日本整形外科学会基礎学術集会
Related Report
-
-
-
-
-
[Presentation] 非特異的腰痛の基礎と臨床 腰椎単純MRI上の加齢変性所見は腰痛の原因か? The Wakayama Spine Study2016
Author(s)
橋爪 洋, 吉村 典子, 山田 宏, 岡 敬之, 寺口 真年, 岩橋 弘樹, 佐々木 貴英, 村木 重之, 松平 浩, 阿久根 徹, 川口 浩, 南出 晃人, 中川 幸洋, 中村 耕三, 吉田 宗人
Organizer
第45回日本脊椎脊髄病学会学術集会
Place of Presentation
幕張メッセ(千葉市)
Year and Date
2016-04-14 – 2016-04-16
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 腰椎椎間板周囲の変化と腰痛の関係 The Wakayama Spine Study2014
Author(s)
寺口 真年, 吉村 典子, 橋爪 洋, 村木 重之, 山田 宏, 岡 敬之, 南出 晃人, 石元 優々, 長田 圭司, 阿久根 徹, 吉田 宗人
Organizer
第44回日本脊椎脊髄病学会学術集会
Place of Presentation
京都国際会館(京都市)
Year and Date
2014-04-17 – 2014-04-19
Related Report
-
-
-