Association of disability with measurements of osteoarthritis and sarcopenia

• Project/Area Number: 26293331
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Muraki Shigeyuki 東京大学, 医学部附属病院, 登録研究員 (40401070)
• Co-Investigator(Kenkyū-buntansha): 吉村 典子 東京大学, 医学部附属病院, 特任教授 (60240355) ; 阿久根 徹 国立障害者リハビリテーションセンター(研究所), その他部局等, 副院長 (60282662) ; 岡 敬之 東京大学, 医学部附属病院, 特任准教授 (60401064)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 運動器障害 / 変形性関節症 / サルコペニア / コホート / 医療、福祉 / 老化 / 疫学 / 予防医学 / 運動器医学 / コホート研究 / 介護予防 / 医療・福祉 / 国際比較

Outline of Final Research Achievements

The present study clarified the measurements of joint space, osteophytosis, other parameterss of osteoarthritis and sarcopenia by gender and age-strata, the association of joint space narrowing with disability, and incident rate and risk factors for osteoarthritis, using the dataset of the ROAD study in Japan and the Herfordshire study and the Chingford study in UK.

Academic Significance and Societal Importance of the Research Achievements

本研究では、大規模コホートを用いて、変形性関節症の定量値だけでなく、サルコペニアデータを加味することにより、これまでになしえなかった運動機能障害への影響および危険因子の解明が実現した。このような知見は、運動機能障害の予測法の確立につながるとともに、予防対策確立につながるため、本研究は今後の臨床医学、予防医学に大きな貢献をすることが十分に期待できる。

Research Products

• [Int'l Joint Research] MRC lifecourse epidemiology unit(英国)
• [Int'l Joint Research] MRC Lifecourse Epidemiology Unit/University of Oxford(英国)
• [Journal Article] Differences in prevalence and associated factors between mild and severe vertebral fractures in Japanese men and women: the third survey of the ROAD study (2019)
  • Author(s): Horii Chiaki、Asai Yoshiki、Iidaka Toshiko、Muraki Shigeyuki、Oka Hiroyuki、Tsutsui Shunji、Hashizume Hiroshi、Yamada Hiroshi、Yoshida Munehito、Kawaguchi Hiroshi、Nakamura Kozo、Akune Toru、Tanaka Sakae、Yoshimura Noriko
  • Journal Title: Journal of Bone and Mineral Metabolism Volume: in press Issue: 5 Pages: 844-853
  • DOI: 10.1007/s00774-018-0981-5
  • Peer Reviewed
• [Journal Article] Factory and construction work is associated with an increased risk of severe lumbar spinal stenosis on MRI: A case control analysis within the wakayama spine study (2019)
  • Author(s): Ishimoto Yuyu、Cooper Cyrus、Ntani Georgia、Yamada Hiroshi、Hashizume Hiroshi、Nagata Keiji、Muraki Shigeyuki、Tanaka Sakae、Yoshimura Noriko、Yoshida Munehito、Walker-Bone Karen
  • Journal Title: American Journal of Industrial Medicine Volume: in press Issue: 5 Pages: 430-438
  • DOI: 10.1002/ajim.22957
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Physical performance decreases in the early stage of cervical myelopathy before the myelopathic signs appear: the Wakayama Spine Study (2019)
  • Author(s): Nagata Keiji、Yoshimura Noriko、Hashizume Hiroshi、Yamada Hiroshi、Ishimoto Yuyu、Muraki Shigeyuki、Nakagawa Yukihiro、Minamide Akihito、Oka Hiroyuki、Kawaguchi Hiroshi、Tanaka Sakae、Nakamura Kozo、Yoshida Munehito
  • Journal Title: European Spine Journal Volume: in press Issue: 5 Pages: 1217-1224
  • DOI: 10.1007/s00586-019-05907-4
  • Peer Reviewed
• [Journal Article] Do sarcopenia and/or osteoporosis increase the risk of frailty? A 4-year observation of the second and third ROAD study surveys (2018)
  • Author(s): Yoshimura N.、Muraki S.、Oka H.、Iidaka T.、Kodama R.、Horii C.、Kawaguchi H.、Nakamura K.、Akune T.、Tanaka S.
  • Journal Title: Osteoporosis International Volume: 29 Issue: 10 Pages: 2181-2190
  • DOI: 10.1007/s00198-018-4596-4
  • Peer Reviewed
• [Journal Article] Factors associated with lumbar spinal stenosis in a large-scale, population-based cohort: The Wakayama Spine Study (2018)
  • Author(s): Maeda Takahiro、Hashizume Hiroshi、Yoshimura Noriko、Oka Hiroyuki、Ishimoto Yuyu、Nagata Keiji、Takami Masanari、Tsutsui Shunji、Iwasaki Hiroshi、Minamide Akihito、Nakagawa Yukihiro、Yukawa Yasutsugu、Muraki Shigeyuki、Tanaka Sakae、Yamada Hiroshi、Yoshida Munehito
  • Journal Title: PLOS ONE Volume: 13 Issue: 7 Pages: e0200208-e0200208
  • DOI: 10.1371/journal.pone.0200208
  • Peer Reviewed
• [Journal Article] Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery (2018)
  • Author(s): Yamada K, Satoh S, Hashizume H, Yoshimura N, Ryohei Kagotani R, Yuyu Ishimoto Y, Abe Y, Toyoda H, Terai H, Masuda T, Muraki S, Nakamura H, Yoshida M
  • Journal Title: J Bone Miner Metab Volume: 37 Issue: 1 Pages: 118-124
  • DOI: 10.1007/s00774-017-0901-0
  • URL: https://ocu-omu.repo.nii.ac.jp/records/2019955
  • Peer Reviewed
• [Journal Article] Serum Levels of Matrix Metalloproteinase-3 and Autoantibodies Related to 2 Rheumatoid Arthritis in the General Japanese Population and their Association with Osteoporosis and Osteoarthritis: The ROAD Study (2017)
  • Author(s): Kodama R, Muraki S, Iidaka T, Oka H, Teraguhi M, Kagotani R, Asai Y, Hashizume H, Yoshida M, Kawaguchi H, Nakamura K, Akune T, Tanaka S, Yoshimura N.
  • Journal Title: J Bone Miner Metab Volume: in press Issue: 2 Pages: 246-253
  • DOI: 10.1007/s00774-017-0834-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of Lumbar Spondylolisthesis with Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study. (2017)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: Spine Volume: 印刷中 Issue: 11 Pages: E666-E671
  • DOI: 10.1097/brs.0000000000001960
  • Peer Reviewed
• [Journal Article] Is osteoporosis a predictor for future sarcopenia, or vice-versa? Four-year observations between the second and third ROAD study surveys. (2017)
  • Author(s): Yoshimura N, Muraki S, Oka H, Iidaka T, Kodama R, Kawaguchi H, Nakamura K, Tanaka S, Akune T:
  • Journal Title: Osteoporos Int Volume: 28 Issue: 1 Pages: 1-7
  • DOI: 10.1007/s00198-016-3823-0
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study. (2017)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Yamada H, Oka H, Minamide A, Nagata K, Ishimoto Y, Kagotani R, Kawaguchi H, Tanaka S, Akune T, Nakamura K, Muraki S, Yoshida M.
  • Journal Title: Osteoarthritis Cartilage Volume: 印刷中 Issue: 7 Pages: 1122-1131
  • DOI: 10.1016/j.joca.2017.01.001
  • NAID: 40021443587
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Quadriceps muscle strength reference value as index for functional deterioration of locomotive organs: Data from 3617 men and women in Japan. (2017)
  • Author(s): Narumi K, Funaki Y, Yoshimura N, Muraki S, Omori G, Nawata A, Seki R
  • Journal Title: J Orthop Sci Volume: 22 Issue: 4 Pages: 765-770
  • DOI: 10.1016/j.jos.2017.03.012
  • Peer Reviewed
• [Journal Article] Radiographic measurements of the hip joint and their associations with hip pain in Japanese men and women: the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study. (2017)
  • Author(s): Iidaka T, Muraki S, Oka H, Kodama R, Tanaka S, Kawacughi H, Nakamura K, Akune T, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 25 Issue: 12 Pages: 2072-2079
  • DOI: 10.1016/j.joca.2017.08.008
  • Peer Reviewed / Open Access
• [Journal Article] MRI-defined paraspinal muscle morphology in Japanese population: The Wakayama Spine Study. (2017)
  • Author(s): Sasaki T, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Iwahashi H, Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M.
  • Journal Title: PLoS One Volume: 12 Issue: 11 Pages: e0187765-e0187765
  • DOI: 10.1371/journal.pone.0187765
  • Peer Reviewed / Open Access
• [Journal Article] Association of Lumbar Spondylolisthesis with Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study (2017)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: SPINE Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The prevalence of tandem spinal stenosis and its characteristics in a population-based MRI study: The Wakayama Spine Study (2017)
  • Author(s): Nagata K, Yoshimura N, Hashizume H, Ishimoto Y, Muraki S, Yamada H, Oka H, Kawaguchi H, Akune T, Tanaka S, Nakamura K, Yoshida M
  • Journal Title: Eur Spine J Volume: in press Issue: 10 Pages: 2529-2535
  • DOI: 10.1007/s00586-017-5072-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study. (2016)
  • Author(s): Kodama R, Muraki S, Oka H, Iidaka T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Morizaki Y, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshimura N.
  • Journal Title: Mod Rheumatol Volume: 26 Issue: 5 Pages: 767-773
  • DOI: 10.3109/14397595.2015.1130673
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. (2016)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0147565-e0147565
  • DOI: 10.1371/journal.pone.0147565
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The Association between the Cross-Sectional Area of the Dural Sac and Low Back Pain in a Large Population: The Wakayama Spine Study. (2016)
  • Author(s): Iwahashi H, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M.
  • Journal Title: PLoS One Volume: 11 Issue: 8 Pages: e0160002-e0160002
  • DOI: 10.1371/journal.pone.0160002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Classification of High Intensity Zones of the Lumbar Spine and Their Association with Other Spinal MRI Phenotypes: The Wakayama Spine Study. (2016)
  • Author(s): Teraguchi M, Samartzis D, Hashizume H, Yamada H, Muraki S, Oka H, Cheung JP, Kagotani R, Iwahashi H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Cheung KM, Yoshimura N, Yoshida M.
  • Journal Title: PLoS One Volume: 11 Issue: 9 Pages: e0160111-e0160111
  • DOI: 10.1371/journal.pone.0160111
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Epidemiology of the locomotive syndrome: The Research on Osteoarthritis/Osteoporosis Against Disability study (2016)
  • Author(s): Yoshimura N, Muraki S, Nakamura K, Tanaka S.
  • Journal Title: Modern Rheum Volume: 27 Issue: 1 Pages: 1-7
  • DOI: 10.1080/14397595.2016.1226471
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prevalence of radiographic hip osteoarthritis and its association with hip pain in Japanese men and women: The ROAD study. (2016)
  • Author(s): Iidaka T, Muraki S, Akune T, Oka H, Kodama R, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 24 Issue: 1 Pages: 117-123
  • DOI: 10.1016/j.joca.2015.07.017
  • Peer Reviewed
• [Journal Article] Incidence of disability and its associated factors in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study. (2015)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
  • Journal Title: J Bone Miner Metab Volume: 33 Issue: 2 Pages: 186-191
  • DOI: 10.1007/s00774-014-0573-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study. (2015)
  • Author(s): Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
  • Journal Title: J Bone Miner Metab Volume: 33 Issue: 2 Pages: 221-229
  • DOI: 10.1007/s00774-014-0583-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Does osteophytosis at the knee predict health-related quality of life decline? A 3-year follow-up of the ROAD study. (2015)
  • Author(s): Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N.
  • Journal Title: Clin Rheumatol. Volume: 34 Issue: 9 Pages: 1589-1597
  • DOI: 10.1007/s10067-014-2687-y
  • Peer Reviewed
• [Journal Article] Serum levels of 25-hydroxyvitamin D and occurrence of musculoskeletal diseases, such as osteoporosis, knee osteoarthritis and lumbar spondylosis: A three-year follow-up of the road study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Kawaguchi H, Tanaka S, Akune T
  • Journal Title: Osteoporos Int Volume: 26 Issue: 1 Pages: 151-161
  • DOI: 10.1007/s00198-014-2844-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mutual associations among musculoskeletal diseases and metabolic syndrome components: A 3-year follow-up of the ROAD study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T.
  • Journal Title: Mod Rheumatol. Volume: 25 Issue: 3 Pages: 438-448
  • DOI: 10.3109/14397595.2014.972607
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The association of combination of disc degeneration, endplate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study (2015)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Nakagawa H, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: Spine J Volume: 15 Issue: 4 Pages: 622-628
  • DOI: 10.1016/j.spinee.2014.11.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Joint space narrowing, body mass index and knee pain: The ROAD study. (2015)
  • Author(s): Muraki S, Akune T, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Tanaka S, Nakamura K, Kawaguchi H, Oka H, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 23 Issue: 6 Pages: 874-881
  • DOI: 10.1016/j.joca.2015.01.011
  • Peer Reviewed
• [Journal Article] Urinary 8-iso-prostaglandin F2a as a marker of metabolic risks in the general Japanese population: The ROAD study. (2015)
  • Author(s): Mure K, Yoshimura N, Hashimoto M, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Takeshita T
  • Journal Title: Obesity 23:1517-1524, 2015. Volume: 23 Issue: 7 Pages: 1517-1524
  • DOI: 10.1002/oby.21130
  • Peer Reviewed
• [Journal Article] Factors affecting changes in the serum levels of 25-hydroxyvitamin D: A 3-year follow-up of the ROAD study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Kawaguchi H, Tanaka S, Akune T
  • Journal Title: Osteoporos Int Volume: 26 Issue: 11 Pages: 2597-605
  • DOI: 10.1007/s00198-015-3184-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between new indices in the locomotive syndrome risk test and decline in mobility: third survey of the ROAD study. (2015)
  • Author(s): Yoshimura N, Musaki S, Oka H, Tanaka S, Ogata T, Kawaguchi H, Akune T, Nakamura K
  • Journal Title: J Orthop Sci Volume: 20 Issue: 5 Pages: 896-905
  • DOI: 10.1007/s00776-015-0741-5
  • Peer Reviewed / Open Access
• [Journal Article] Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: The ROAD study. (2015)
  • Author(s): Muraki S, Akune T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: BMC musculoskeltal disorders Volume: 16 Issue: 1 Pages: 305-305
  • DOI: 10.1186/s12891-015-0737-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Does Osteophytosis at the Knee Predict Health-related Quality of Life Decline? A 3-Year Follow-up of the ROAD Study (2015)
  • Author(s): Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N
  • Journal Title: Clin Rheumatol Volume: in press
  • Peer Reviewed
• [Journal Article] Urinary 8-isoprostane as a Biomarker of Metabolic Syndrome Risk in the General Japanese Population: The ROAD Study. (2015)
  • Author(s): Mure K, Yoshimura N, Hashimoto M, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Takeshita T.
  • Journal Title: Obesity Volume: in press
  • Peer Reviewed
• [Journal Article] Prevalence, incidence and progression of lumbar spondylosis by gender and age strata. (2014)
  • Author(s): Muraki S, Yoshimura N, Akune T, Tanaka S, Takahashi I, Fujiwara S
  • Journal Title: Mod Rheumatol Volume: 24 Issue: 4 Pages: 657-661
  • DOI: 10.3109/14397595.2013.843761
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prevalence and progression of the radiographic ossification of posterior longitudinal ligament and its associated factors in the Japanese populations: A 3-year follow-up of the ROAD study. (2014)
  • Author(s): Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T
  • Journal Title: Osteoporos Int Volume: 25 Issue: 3 Pages: 1089-1098
  • DOI: 10.1007/s00198-013-2489-0
  • Peer Reviewed
• [Journal Article] Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts: The ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N.
  • Journal Title: Geriatr Gerontol Int Volume: in press Issue: 3 Pages: 695-701
  • DOI: 10.1111/ggi.12155
  • Peer Reviewed / Open Access
• [Journal Article] Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Osteoporos Int Volume: 25 Issue: 3 Pages: 1081-8
  • DOI: 10.1007/s00198-013-2550-z
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study. (2014)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 22 Issue: 1 Pages: 104-110
  • DOI: 10.1016/j.joca.2013.10.019
  • Peer Reviewed
• [Journal Article] Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: the ROAD study. (2014)
  • Author(s): Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Mod Rheumatol. Volume: 24 Issue: 6 Pages: 966-973
  • DOI: 10.3109/14397595.2014.883055
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts: The ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N
  • Journal Title: Geriatr Gerontol Int Volume: 14 Issue: 3 Pages: 695-701
  • DOI: 10.1007/s00776-014-0537-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based MRI study: The Wakayama Spine Study. (2014)
  • Author(s): 52. Nagata K, Yoshimura N, Hashizume H, Muraki S, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Spine J Volume: in press Issue: 12 Pages: 2811-2817
  • DOI: 10.1016/j.spinee.2014.03.051
  • Peer Reviewed / Open Access
• [Journal Article] Association of dietary intake with joint space narrowing and osteophytosis at the knee in Japanese men and women: the ROAD study. (2014)
  • Author(s): Muraki S, Akune T, En-Yo Y, Yoshida M, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N
  • Journal Title: Mod Rheumatol Volume: 24 Issue: 2 Pages: 236-42
  • DOI: 10.3109/14397595.2013.854055
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women : The Longitudinal Cohorts of Motor System Organ (LOCOMO) study (2013)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
  • Journal Title: J Bone Miner Metab Volume: 32 Issue: 5 Pages: 524-532
  • DOI: 10.1007/s00774-013-0522-1
  • Peer Reviewed / Open Access
• [Presentation] 全脊椎X線画像からみた椎体骨折の有病率と腰痛・歩行能力の関連: ROAD study第4回調査より (2018)
  • Author(s): 堀井千彬、飯高世子、村木重之、岡敬之、橋爪洋、山田宏、吉田宗人、田中栄、吉村典子
  • Organizer: 第47回日本脊椎脊髄病学会学術集会
• [Presentation] 変形性股関節症の発生率と危険因子 -The ROAD study- (2018)
  • Author(s): 飯高世子、村木重之、岡敬之、堀井千彬、田中栄、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第91回日本整形外科学会学術総会
• [Presentation] 全脊椎X線画像からみた椎体骨折の有病率：ROAD study 第4回調査より (2018)
  • Author(s): 堀井千彬、飯高世子、村木重之、岡敬之、川口浩、中村耕三、阿久根徹、田中栄、吉村典子
  • Organizer: 第91回日本整形外科学会学術総
• [Presentation] フレイルとロコモの有病率と相互関係：ROADスタディ第3回調査より (2018)
  • Author(s): 吉村典子、飯高世子、村木重之、堀井千彬、岡敬之、川口浩、阿久根徹、中村耕三、田中栄
  • Organizer: 第30回日本運動器科学会
• [Presentation] 変形性股関節症の発生率と寛骨臼形成不全との関連 -The ROAD study- (2018)
  • Author(s): 飯高世子、村木重之、岡敬之、堀井千彬、田中栄、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第30回日本運動器科学会
• [Presentation] フレイルとロコモの相互関係：ROADスタディより (2018)
  • Author(s): 吉村典子、飯高世子、村木重之、堀井千彬、岡敬之、川口浩、阿久根徹、中村耕三、田中栄
  • Organizer: 第31回日本臨床整形外科学会学術集会
• [Presentation] 変形性股関節症の発生率：10年間の地域追跡コホートより (2018)
  • Author(s): 飯高世子、村木重之、岡敬之、田中栄、中村耕三、阿久根徹、吉村典子
  • Organizer: 第36回日本骨代謝学会学術集会
• [Presentation] 変形性股関節症の発生率と危険因子の解明 -The ROAD study- (2018)
  • Author(s): 飯高世子、村木重之、岡敬之、堀井千彬、田中栄、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第20回日本骨粗鬆症学会
• [Presentation] Prevalence and cumulative incidence of morphometric vertebral fractures in Japanese men and women: the Research on Osteoarthritis/Osteoporosis against Disability study. (2018)
  • Author(s): Horii C, Iidaka T, Muraki S, Oka H, Hashizume H, Yamada H, Yoshida M, Tanaka S, Yoshimura N
  • Organizer: WCO-IOF-ESCEO 2018
  • Int'l Joint Research
• [Presentation] Profiles and Risk Factors for The Occurrence of Osteosarcopenia: The ROAD Study. (2018)
  • Author(s): Yoshimura N, Muraki S, Oka H, Iidaka T, Horii C, Kawaguchi H, Nakamura K, Akune T, Tanaka S
  • Organizer: WCO-IOF-ESCEO 2018
  • Int'l Joint Research
• [Presentation] Osteoporosis as a risk factor for the occurrence of frailty: a four-year follow-up of the ROAD study. (2018)
  • Author(s): Yoshimura N, Muraki S, Oka H, Iidaka T, Horii C, Kawaguchi H, Nakamura K, Akune T, Tanaka S
  • Organizer: Bone Research Society (BRS) annual meeting 2018
  • Int'l Joint Research
• [Presentation] 大規模住民コホート研究による運動器疾患の疫学指標、危険因子の解明 (2016)
  • Author(s): 村木重之
  • Organizer: 第34回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2016-07-20
  • Invited
• [Presentation] Threshold of joint space width for knee pain: The ROAD study. (2016)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N.
  • Organizer: EULAR
  • Place of Presentation: London
  • Year and Date: 2016-06-08
  • Int'l Joint Research
• [Presentation] 変形性関節症の疫学 The ROAD Study (2015)
  • Author(s): 村木重之
  • Organizer: 日本関節病学会
  • Place of Presentation: 札幌コンベンションセンター（北海道・札幌市）
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] Sarcopenia is independently associated with knee pain: The ROAD study (2015)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Organizer: ASBMR
  • Place of Presentation: Seattle, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] Sarcopenia - prevalence, incidence, and association with osteoporosis: A four-year follow-up of the ROAD study (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: ASBMR
  • Place of Presentation: Seattle, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] Sarcopenia in Japan (2015)
  • Author(s): 村木重之
  • Organizer: 第17回日本骨粗鬆症学会
  • Place of Presentation: 広島国際会議場（広島県・広島市）
  • Year and Date: 2015-09-17
  • Invited
• [Presentation] Prognosis of Vitamin D Insufficiency: A 3-Year Follow-Up of the ROAD Study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: The European League Against Rheumatism (EULAR)
  • Place of Presentation: Rome, Italy
  • Year and Date: 2015-06-10 – 2015-06-13
• [Presentation] Prognosis of Vitamin D Insufficiency: A 3-Year Follow-Up of the ROAD Study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: The European League Against Rheumatism (EULAR)2015
  • Place of Presentation: Rome, Italy
  • Year and Date: 2015-06-10
  • Int'l Joint Research
• [Presentation] Knee Symptoms Are More Strongly Associated With Quadriceps Muscle Strength Than Grip Strength Or Muscle Mass: The ROAD Study. (2015)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Organizer: The European League Against Rheumatism (EULAR)
  • Place of Presentation: Rome, Italy
  • Year and Date: 2015-06-10
  • Int'l Joint Research
• [Presentation] サルコペニアの疫学 (2015)
  • Author(s): 村木重之
  • Organizer: 日本骨形態計測学会
  • Place of Presentation: 倉敷市芸文館（岡山県・倉敷市）
  • Year and Date: 2015-06-04
  • Invited
• [Presentation] 変形性股関節症の有病率と股関節痛との関連 (2015)
  • Author(s): 村木 重之
  • Organizer: 日本整形外科学会
  • Place of Presentation: 神戸
  • Year and Date: 2015-05-21 – 2015-05-24
  • Invited
• [Presentation] 変形性股関節症と股関節痛との関連 (2015)
  • Author(s): 村木重之
  • Organizer: 日本整形外科学会
  • Place of Presentation: 神戸ポートピアホテル他（兵庫県・神戸市）
  • Year and Date: 2015-05-21
  • Invited
• [Presentation] Muscle strength rather than muscle mass of the lower limb is associated with knee pain: The ROAD study. (2015)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Organizer: World Congress on Osteoporosis,Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO)
  • Place of Presentation: Milan, Italy
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] 大規模縦断研究による変形性膝関節症の疫学 (2015)
  • Author(s): 村木重之
  • Organizer: 膝OAと運動・装具療法セミナー
  • Place of Presentation: 仙台
  • Year and Date: 2015-01-23
  • Invited
• [Presentation] X線画像診断による軟骨変性の特異度 (2014)
  • Author(s): 村木重之
  • Organizer: 第31回膝関節フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2014-12-06
  • Invited
• [Presentation] Effect of Osteophytosis at the Knee on Health-related Quality of Life: A 3-year follow-up of the ROAD study (2014)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N.
  • Organizer: IOF regionals
  • Place of Presentation: Taipei
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] Mutual associations among diseases causing disability, such as musculoskeletal diseases, metabolic syndrome components, and mild cognitive impairment: A 3-year follow-up of the population-based cohort ROAD (2014)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T.
  • Organizer: IOF regionals
  • Place of Presentation: Taipei
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] Prevalence of Hand Osteoarthritis in the General Japanese Population: The ROAD Study. (2014)
  • Author(s): Kodama R, Oka H, Muraki S, Kawaguchi H, Tanaka S, Nakamura K, Akune T, Yoshimura N.
  • Organizer: IOF regionals
  • Place of Presentation: Taipei
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] 変形性関節症と骨粗鬆症の最新疫学知見 The ROAD Study (2014)
  • Author(s): 村木重之
  • Organizer: 日本関節病学会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-06 – 2014-11-07
  • Invited
• [Presentation] Does Osteophytosis at the Knee Predict Health-related Quality of Life Decline? A 3-Year Follow-up of the ROAD Study (2014)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura, K, Oka H, Yoshimura N
  • Organizer: EULAR (the European league against rheumatism) Congress
  • Place of Presentation: Paris, France
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] Mutual associations among musculoskeletal diseases, metabolic syndrome, and cognitive impairment: A 3-year follow-up of the ROAD study. (2014)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: EULAR (The European League Against Rheumatism) Congress
  • Place of Presentation: Paris, France
  • Year and Date: 2014-06-12 – 2014-06-15
• [Book] 検査値読み方事典 (2014)
  • Author(s): 村木 重之
  • Total Pages: 937
  • Publisher: 総合医学社
• [Book] 運動とサルコペニア (2014)
  • Author(s): 村木 重之
  • Total Pages: 8
  • Publisher: Clinical Calcium
• [Book] 変形性腰椎症 リスク因子、腰痛・QOLとの関連 (2014)
  • Author(s): 村木 重之
  • Total Pages: 8
  • Publisher: 整形・災害外科
• [Book] 変形性膝関節症 リスク因子、膝痛・QOLとの関連 (2014)
  • Author(s): 村木 重之
  • Total Pages: 8
  • Publisher: 整形・災害外科