| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
Ageing is a pivotal risk factor for osteoporosis and osteoarthritis. The stress-response and chromatin-silencing factor Sir2, a yeast sirtuin, is a NAD+-dependent histone deacetylase and is involved in controlling ageing. Herein we sought to investigate the involvement of Sirt6 in the etiology of osteoporosis and osteoarthritis. Sirt6 haploinsufficiency in mice promoted the expression of inflammatory cytokines in the IPFP. Mesenchyme-specific Sirt6-deficient mice revealed both attenuated chondrocyte hypertrophy and proteoglycan synthesis, although chondrocyte senescence was enhanced as shown in the aged WT mice. Thus Sirt6 has key roles in the relationship among ageing, metabolic syndrome, and OA.
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