The rola of Sirt6 in bone and cartilage metabolism
Project/Area Number |
26293332
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
OKAWA Atsushi 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30251507)
|
Co-Investigator(Kenkyū-buntansha) |
麻生 義則 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (50345279)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
Keywords | Sirt6 / senescence / 骨代謝 / 軟骨代謝 / 骨細胞 / 老化 / 骨軟骨 / サーチュイン / Sirt4 / 変形性膝関節症 / 加齢 / 骨粗鬆症 / 変形性関節症 |
Outline of Final Research Achievements |
Ageing is a pivotal risk factor for osteoporosis and osteoarthritis. The stress-response and chromatin-silencing factor Sir2, a yeast sirtuin, is a NAD+-dependent histone deacetylase and is involved in controlling ageing. Herein we sought to investigate the involvement of Sirt6 in the etiology of osteoporosis and osteoarthritis. Sirt6 haploinsufficiency in mice promoted the expression of inflammatory cytokines in the IPFP. Mesenchyme-specific Sirt6-deficient mice revealed both attenuated chondrocyte hypertrophy and proteoglycan synthesis, although chondrocyte senescence was enhanced as shown in the aged WT mice. Thus Sirt6 has key roles in the relationship among ageing, metabolic syndrome, and OA.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] A small molecule PAI-1 inhibitor prevents bone loss by stimulating bone formation in a murine estrogen deficiency-induced osteoporosis model2018
Author(s)
Jin G, Aobulikasimu A, Piao J, Aibibula Z, Koga D, Sato S, Ochi H, Tsuji K, Nakabayashi T, Miyata T, Okawa A, Asou Y.
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Journal Title
FEBS Open Bio
Volume: 8(4)
Issue: 4
Pages: 523-532
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 新規PAI-1阻害剤はマウス骨髄除去モデルにおいて骨形成を促進する2017
Author(s)
Aobulikasimu Alkebaier, 金 光文, 朴 金瑛, Zulipiya Aibibula, 段 孝, 市村 敦彦, 宮田 敏男, 越智 広樹, 佐藤 信吾, 大川 淳, 麻生 義則
Organizer
日本整形外科基礎学術集会
Related Report
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[Presentation] 新規PAI-1阻害薬は閉経後骨粗鬆症モデルの骨密度を回復させる2017
Author(s)
金 光文, 朴 英瑛, Aobulikasimu Alkebaier, Zulipiya Aibibula, 段 孝, 市村 敦彦, 赤堀 浩司, 宮田 敏男, 越智 広樹, 佐藤 信吾, 大川 淳, 麻生 義則
Organizer
日本整形外科基礎学術集会
Related Report
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