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Analysis of the dysregulation of the brain reward system induced by chronic pain

Research Project

Project/Area Number 26293346
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionHoshi University

Principal Investigator

Narita Minoru  星薬科大学, 薬学部, 教授 (40318613)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords中脳辺縁ドパミン神経 / 疼痛制御 / モルヒネ / エピジェネティクス / オプトジェネティクス / DREADD / 中脳ドパミン神経 / 側坐核 / 神経科学 / 疼痛
Outline of Final Research Achievements

In this research, we first clarified that the intrinsic neuronal excitability of ventral tegmental area (VTA) dopaminergic neurons projecting to the nucleus accumbens (N.Acc.) was significantly reduced in neuropathic pain- and cancer pain-model mice using patch clamp electrophysiology. Under these conditions, we found that phasic activation of mesolimbic dopaminergic neurons produced a significant but transient anti-allodynic effect in these mice using optogenetics or designer receptors exclusively activated by designer drugs (DREADD) technology. On the other hand, we revealed that the expression of Dnmt3a was significantly increased along with the downregulation of miR-200b/429 expression in the N.Acc. under the neuropathic pain condition. Furthermore, we found that a significant decrease in Pde10a expression in the N.Acc. was caused by an increase in the level of DNA methylation at the Pde10a promoter.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (45 results)

All 2018 2017 2016 2015 2014 2013

All Journal Article (29 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 25 results,  Open Access: 24 results,  Acknowledgement Compliant: 11 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Book (3 results)

  • [Journal Article] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system2018

    • Author(s)
      Watanabe M, Sugiura Y, Sugiyama E, Narita M, Navratilova E, Kondo T, Uchiyama N, Yamanaka A, Kuzumaki N, Porreca F, Narita M
    • Journal Title

      Molecular Pain

      Volume: 14 Pages: 1-10

    • DOI

      10.1177/1744806918754934

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer2018

    • Author(s)
      Watanabe Moe、Narita Michiko、Hamada Yusuke、Yamashita Akira、Tamura Hideki、Ikegami Daigo、Kondo Takashige、Shinzato Tatsuto、Shimizu Takatsune、Fukuchi Yumi、Muto Akihiro、Okano Hideyuki、Yamanaka Akihiro、Tawfik Vivianne L、Kuzumaki Naoko、Navratilova Edita、Porreca Frank、Narita Minoru
    • Journal Title

      Molecular Pain

      Volume: 14 Pages: 1-10

    • DOI

      10.1177/1744806918756406

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 特異的神経制御研究が照らし出す運動療法の未来:脳内報酬ドパミン系神経ネットワークの重要性2017

    • Author(s)
      若泉謙太、近藤貴茂、濱田祐輔、成田 年
    • Journal Title

      ペインクリニック

      Volume: 38 Pages: 580-589

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 慢性疼痛下における脳内報酬系の破綻の分子メカニズム2017

    • Author(s)
      濱田祐輔、渡邉 萌、成田道子、葛巻直子、成田 年
    • Journal Title

      ペインクリニック

      Volume: 38 Pages: 1625-1633

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 脳内エピジェネティクス変動に基づく慢性疼痛病態の包括的管理2017

    • Author(s)
      渡邉 萌、五十嵐勝秀、成田 年
    • Journal Title

      麻酔

      Volume: 66

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with gi-dreadd in mice.2016

    • Author(s)
      Wakaizumi K, Kondo T, Hamada Y, Narita M, Kawabe R, Narita H, Watanabe M, Kato S, Senba E, Kobayashi K, Kuzumaki N, Yamanaka A, Morisaki H, *Narita M
    • Journal Title

      Mol Pain

      Volume: 12 Pages: 1-11

    • DOI

      10.1177/1744806916681567

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 痛みの記憶とエピジェネティクス2016

    • Author(s)
      成田 年, 五十嵐勝秀, 田村英紀, 成田道子, 葛巻直子, 田中隆治
    • Journal Title

      Locomotive Pain frontier

      Volume: 5 Pages: 14-22

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性疼痛におけるエピジェネティクス機構の理解2016

    • Author(s)
      成田 年
    • Journal Title

      痛みの Clinical Neuroscience

      Volume: 71 Pages: 1006-1011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The importance of epigenetic analysis in pain2016

    • Author(s)
      池上大悟、五十嵐勝秀、大塚まき、葛巻直子、成田 年
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 147 Issue: 4 Pages: 225-229

    • DOI

      10.1254/fpj.147.225

    • NAID

      130005143845

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in the expression of IL-6-mediated microRNAs in the dorsal root ganglion under neuropathic pain in mice.2015

    • Author(s)
      Hori N, Narita M, Yamashita A, Horiuchi H, Hamada Y, Kondo T, Watanabe M, Igarashi K, Kawata M, Shibasaki M, Yamazaki M, Kuzumaki N, Inada E, Ochiya T, Iseki M, Mori T, Narita M.
    • Journal Title

      Synapse

      Volume: なし Issue: 8 Pages: 21902-21902

    • DOI

      10.1002/syn.21902

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid2015

    • Author(s)
      Juliandi B, Tanemura K, Igarashi K, Tominaga T, Furukawa Y, Otsuka M, Moriyama N, Ikegami D, Abematsu M, Sanosaka T, Tsujimura K, Narita M, Kanno J, Nakashima K
    • Journal Title

      Stem Cell Rep

      Volume: 5 Issue: 6 Pages: 996-1009

    • DOI

      10.1016/j.stemcr.2015.10.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenetic mechanisms of chronic pain.2015

    • Author(s)
      Descalzi G, Ikegami D, Ushijima T, Nestler EJ, Zachariou V, Narita M.
    • Journal Title

      Trends Neurosci.

      Volume: 38(4) Issue: 4 Pages: 237-246

    • DOI

      10.1016/j.tins.2015.02.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peripheral opioid antagonist enhances the effect of anti-Tumor drug by blocking a cell growth-suppressive pathway in vivo2015

    • Author(s)
      Masami Suzuki, Fumiko Chiwaki, Yumi Sawada, Maho Ashikawa, Kazuhiko Aoyagi, Takeshi Fujita, Kazuyoshi Yanagihara, Masayuki Komatsu, Minoru Narita, Tsutomu Suzuki, Hiroshi Nagase, Ryoji Kushima, Hiromi Sakamoto, Takeo Fukagawa, Hitoshi Katai, Hitoshi Nakagama, Teruhiko Yoshida, Yasuhito Uezono, Hiroki Sasaki
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 4 Pages: 1-18

    • DOI

      10.1371/journal.pone.0123407

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pain and emotional dysregulation: Cellular memory due to pain2015

    • Author(s)
      Narita M, Watanabe M, Hamada Y, Tamura H, Ikegami D, Kuzumaki N, Igarashi K.
    • Journal Title

      Nihon Shinkei Seishin Yakurigaku Zasshi.

      Volume: 35 Pages: 89-95

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 慢性疼痛におけるエピジェネティクス研究の最前線2015

    • Author(s)
      河田美穂、葛巻直子、成田 年
    • Journal Title

      医学のあゆみ

      Volume: 255 Pages: 677-682

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Epigenetic mechanisms of chronic pain.2015

    • Author(s)
      Descalzi G, Ikegami D, Ushijima T, Nestler EJ, Zachariou V, Narita M
    • Journal Title

      Trends Neurosci

      Volume: 38 Pages: 237-46

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peripheral opioid antabonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo.2015

    • Author(s)
      Suzuki M, Chiwaki F, Sawada Y, Ashikawa M, Aoyagi K, Fujita T, Yanagihara K, Komatsu M, Narita M, Suzuki T, Nagase H, Kushima R, Sakamoto H, Fukagawa T, Katai H, Nakagama H, Yoshida T, Uezono Y, Sasaki H
    • Journal Title

      PLoS One

      Volume: 10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neuropathic pain-like stimuli change the expression of ribosomal proteins in the amygdala: genome-wide search for a “pain-associated anxiety-related factor”2015

    • Author(s)
      Saisu H, Igarashi K, Narita M, Ikegami D, Kuzumaki N, Wajima K, Nakagawa T, Narita M.
    • Journal Title

      Jpn. J. Pharm. Palliat. Care Sci

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of activated locus coeruleus-noradrenergic neurons in pain-related sleep disorders.2015

    • Author(s)
      Koh K, Hamada A, Hamada Y, Yanase M, Sakaki M, Someya K, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M
    • Journal Title

      Neurosci lett

      Volume: 589 Pages: 200-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of Moesin in the Development of Morphine Analgesic Tolerance through P-glycoprotein at the Blood-Brain Barrier.2014

    • Author(s)
      Kobori T, Fujiwara S, Miyagi K, Harada S, Nakamoto K, Nakagawa T, Takahashi H, Narita M, Tokuyama S.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 29 Pages: 482-9

    • NAID

      130004933556

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.2014

    • Author(s)
      Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S.
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 348 Issue: 3 Pages: 383-392

    • DOI

      10.1124/jpet.113.208108

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain.2014

    • Author(s)
      Yamashita A, Hamada A, Suhara Y, Kawabe R, Yanase M, Kuzumaki N, Narita M, Matsui R, Okano H, Narita M.
    • Journal Title

      Synapse

      Volume: 68 Issue: 6 Pages: 235-247

    • DOI

      10.1002/syn.21733

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state.2014

    • Author(s)
      Odo M, Koh K, Takada T, Yamashita A, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M.
    • Journal Title

      Synapse

      Volume: 68 Issue: 4 Pages: 153-158

    • DOI

      10.1002/syn.21728

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms of cisplatin-induced muscle atrophy.2014

    • Author(s)
      Sakai H, Sagara A, Arakawa K, Sugiyama R, Hirosaki A, Takase K, Jo A, Sato K, Chiba Y, Yamazaki M, Matoba M, Narita M
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 278 Issue: 2 Pages: 190-199

    • DOI

      10.1016/j.taap.2014.05.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Augmented bronchial smooth muscle contractility induced by aqueous cigarette smoke extract in rats.2014

    • Author(s)
      Sakai H, Watanabe A, Fujita A, Misawa M, Narita M, Chiba Y.
    • Journal Title

      J Smooth Muscle Res.

      Volume: 50 Pages: 39-47

    • NAID

      130004432186

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distribution of aquaporin genes and selection of individual reference genes for quantitative real-time RT-PCR analysis in multiple tissues of the mouse.2014

    • Author(s)
      Sakai H, Sato K, Kai Y, Shoji T, Hasegawa S, Nishizaki M, Sagara A, Yamashita A, Narita M.
    • Journal Title

      Can J Physiol Pharmacol

      Volume: 92 Issue: 9 Pages: 789-796

    • DOI

      10.1139/cjpp-2014-0157

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon.2014

    • Author(s)
      Sakai H, Sagara A, Matsumoto K, Jo A, Hirosaki A, Takase K, Sugiyama R, Sato K, Ikegami D, Horie S, Matoba M, Narita M.
    • Journal Title

      Pharmacol Res.

      Volume: 87 Pages: 71-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice.2014

    • Author(s)
      Zhao M, Nakamura S, Miyake T, So K, Shirakawa H, Tokuyama S, Narita M, Nakagawa T, Kaneko S.
    • Journal Title

      J Pharmacol Sci.

      Volume: 124 Pages: 514-7

    • NAID

      130003391509

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Kappa-Opioids inhibit tumor angiogenesis by suppressing VEGF signaling.2013

    • Author(s)
      Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M.
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 3213-3213

    • DOI

      10.1038/srep03213

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳内痛み感受性細胞の同定と人工的制御の試み2017

    • Author(s)
      成田 年
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Complex interplay between pain relief and opioid addiction: chronic pain diminishes the mesolimbic dopaminergic network2017

    • Author(s)
      Narita M
    • Organizer
      Asian College of Neuropsychopharmacology (AsCNP) 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳内エピジェネティクス変動に基づく慢性疼痛病態の統合的理解2017

    • Author(s)
      成田 年
    • Organizer
      日本麻酔科学会 第64回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疾患細胞薬理学:疼痛感受性細胞及び鎮痛薬感受性細胞の同定/解析と人為的制御2017

    • Author(s)
      成田 年
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Epigenetic modifications in chronic pain syndromes2016

    • Author(s)
      成田 年
    • Organizer
      IASP 2016
    • Place of Presentation
      横浜
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuropathic pain negatively modulates mesolimbic dopaminergic transmission related to suppression of the analgesic potency and abuse potential of morphine2016

    • Author(s)
      成田 年
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      ソウル
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] パシフィコ横浜2016

    • Author(s)
      葛巻 直子、成田 年
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 光遺伝学や薬理遺伝学を用いた痛みの研究の最前線:慢性疼痛発現機序探索のための“痛みネットワーク”や“痛みオンセル”解析2016

    • Author(s)
      成田 年
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性疼痛と細胞記憶2015

    • Author(s)
      成田 年
    • Organizer
      第29回日本ニューロモデュレーション学会
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 難治性疼痛発現機序探索のための“痛みネットワーク”解析に連動した複合型オミクス解析:ケミカルジェネティクスシステムやゲノムワイド解析の応用2015

    • Author(s)
      成田 年
    • Organizer
      第88 回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] エピジェネティクス修飾異常に伴う”痛みの細胞記憶”の形成2014

    • Author(s)
      成田 年
    • Organizer
      第9回臨床ストレス応答学会大会
    • Place of Presentation
      岡山
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 疼痛分子神経科学領域の次世代型研究の提案2014

    • Author(s)
      成田 年
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Pain-induced epigenetic cell modification and significance of primary pain-control2014

    • Author(s)
      成田 年
    • Organizer
      IASP 15th World Congress on Pain
    • Place of Presentation
      Buenos Aires
    • Year and Date
      2014-06-06 – 2014-06-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] δ-opioids and Neurogenesis. Neural functions of the Delta-Opioid Receptor2015

    • Author(s)
      Kuzumaki N and Narita M
    • Total Pages
      9
    • Publisher
      Springer International Publishing
    • Related Report
      2015 Annual Research Report
  • [Book] 分子病態薬理学I2014

    • Author(s)
      成田 年
    • Total Pages
      223
    • Publisher
      京都廣川書店
    • Related Report
      2014 Annual Research Report
  • [Book] がん疼痛緩和ケア2014

    • Author(s)
      成田 年
    • Total Pages
      18
    • Publisher
      じほう
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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