Common genetic mechanisms underlying vulnerability to pain and sensitivity to analgesics among different populations of patients with pain.
Project/Area Number |
26293347
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology
|
Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
IKEDA Kazutaka 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656)
|
Co-Investigator(Kenkyū-buntansha) |
西澤 大輔 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (80450584)
福田 謙一 東京歯科大学, 歯学部, 教授 (80228907)
笠井 慎也 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (20399471)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
Keywords | 薬物反応性 / ゲノム / 薬理学 / 脳神経疾患 / 医療・福祉 / 国際研究者交流 |
Outline of Final Research Achievements |
Huge individual differences in vulnerability to pain and in responsibility to its therapy hamper effective therapy for pain. In the present study, we analyzed genetic polymorphism data and clinical data and found polymorphisms associated with responsibility to analgesics. Using these polymorphisms and demographic data of patients, we constructed a formula for predicting adequate amount of analgesic for postoperative pain in individual patients. We further constructed formulas for perioperative pain and verified them in other populations of patients with perioperative pain. Personalized pain treatment has begun using prediction formulas, and improvements in personalized pain treatment are expected as scientific knowledge further expands in the future.
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Report
(5 results)
Research Products
(269 results)
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Author(s)
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[Presentation] Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence.2015
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[Presentation] 喫煙関連遺伝子多型の同定とその機能解析.2015
Author(s)
池田和隆, 西澤大輔, 笠井慎也, 高松幸雄, 萩野洋子, 椙村春彦
Organizer
公益財団法人喫煙科学研究財団 平成26年度助成研究発表会
Place of Presentation
京王プラザホテル(東京都新宿区)
Year and Date
2015-07-23
Related Report
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[Presentation] Specific regions display altered grey matter volume in mu-opioid receptor knockout mice: mri voxel-based morphometry.2014
Author(s)
Sora I, Sasaki K, Sumiyoshi A, Nonaka H, Kasahara Y, Ikeda K, Hall FS, Uhl GR, Watanabe M, Kawashima R
Organizer
The 53rd Annual Meeting of American College of Neuropsychopharmacology (ACNP 53rd Annual Meeting)
Place of Presentation
Phoenix, USA
Year and Date
2014-12-07 – 2014-12-11
Related Report
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[Presentation] Differences in responsiveness between methamphetamine, nisoxetine and methylphenidate may reflect specific developmental characteristics in juvenile DAT KO mice.2014
Author(s)
Kubo Y, Kasahara Y, Arime Y, Hall FS, Takamatsu Y, Ikeda K, Uhl GR, Sora I, Tomita H
Organizer
Society for Neuroscience 2014
Place of Presentation
Washington DC, USA
Year and Date
2014-11-15 – 2014-11-19
Related Report
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[Presentation] PCLO SNP rs13438494 regulates DA and 5-HT uptake, accompanied with splicing efficiency and dependence-like behaviors in genomic association studies.2014
Author(s)
Uno K, Nishizawa D, Seo S, Sasaki N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Ikeda K, Miyamoto Y, Nitta A
Organizer
29th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-24
Related Report
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[Presentation] Associations of an orexin (hypocretin) receptor 2 gene polymorphism with nicotine dependence found in genome-wide and following association studies.2014
Author(s)
Nishizawa D, Kasai S, Hasegawa J, Sato N, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Tanaka M, Sugimura H, Ikeda K
Organizer
29th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-23
Related Report
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[Presentation] Personalized pain control.2014
Author(s)
Ikeda K, Nishizawa D, Hayashida M, Fukuda K
Organizer
2014 YONSEI BK21 PLUS-IGAKUKEN Joint Symposium
Place of Presentation
Soul, Korea
Year and Date
2014-06-20
Related Report
Invited
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