Common genetic mechanisms underlying vulnerability to pain and sensitivity to analgesics among different populations of patients with pain.

• Project/Area Number: 26293347
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: IKEDA Kazutaka 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656)
• Co-Investigator(Kenkyū-buntansha): 西澤 大輔 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (80450584) ; 福田 謙一 東京歯科大学, 歯学部, 教授 (80228907) ; 笠井 慎也 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (20399471)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000); Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 薬物反応性 / ゲノム / 薬理学 / 脳神経疾患 / 医療・福祉 / 国際研究者交流

Outline of Final Research Achievements

Huge individual differences in vulnerability to pain and in responsibility to its therapy hamper effective therapy for pain. In the present study, we analyzed genetic polymorphism data and clinical data and found polymorphisms associated with responsibility to analgesics. Using these polymorphisms and demographic data of patients, we constructed a formula for predicting adequate amount of analgesic for postoperative pain in individual patients. We further constructed formulas for perioperative pain and verified them in other populations of patients with perioperative pain. Personalized pain treatment has begun using prediction formulas, and improvements in personalized pain treatment are expected as scientific knowledge further expands in the future.

Research Products

• [Int'l Joint Research] カルガリー大学(カナダ)
• [Int'l Joint Research] スプリト大学(クロアチア)
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• [Journal Article] Association between rs2275913 single-nucleotide polymorphism of the interleukin-17A gene and perioperative analgesic use in cosmetic orthognathic surgery (2018)
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• [Journal Article] Association between the rs7583431 single-nucleotide polymorphism close to the activating transcription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the cold pain test. (2018)
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• [Journal Article] Opioid and non-dopamine reward circuitry and state-dependent mechanisms. (2018)
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• [Journal Article] Association between N-methyl-D-aspartate receptor 2B subunit gene polymorphisms and personality traits in a young Japanese population. (2018)
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• [Journal Article] A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence. (2018)
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• [Journal Article] Genome-wide association study identifies polymorphisms associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test (2018)
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• [Journal Article] Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy. (2018)
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• [Journal Article] Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain (2018)
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• [Journal Article] A pharmacogenetics approach to pain management. (2018)
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• [Journal Article] 依存の神経・分子メカニズム解析のための動物モデル. (2018)
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• [Journal Article] Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine. (2017)
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• [Journal Article] Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese (2017)
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• [Journal Article] No association between the polymorphism rs6943555 in the AUTS2 gene and personality traits in Japanese university students (2017)
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• [Journal Article] Opioid dose and neuropathic pain before and after electroconvulsive therapy (2017)
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• [Journal Article] JSNP Excellent Presentation Award for CINP2016: Association between autism susceptibility candidate 2 haplotypes and alcohol dependence in a Japanese population. (2017)
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• [Journal Article] JSNP Excellent Presentation Award for CINP2016: 注意欠如/ 多動性障害モデルマウスにおけるメチルフェニデートの報酬効果の変化. (2017)
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• [Journal Article] JSNP Excellent Presentation Award for CINP2016: ゲノムワイド関連解析 (GWAS) による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定. (2017)
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• [Journal Article] 遺伝子多型に基づいた個別鎮痛法の開発. (2017)
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• [Journal Article] ペインクリニックにおける精密医療. (2017)
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• [Journal Article] Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain. (2017)
  • Author(s): Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
  • Journal Title: Pain Med Volume: 印刷中
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• [Journal Article] Distinct roles of opioid and dopamine systems in lateral hypothalamic intracranial self-stimulation. (2017)
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• [Journal Article] Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice. (2017)
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• [Journal Article] Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery. (2016)
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• [Journal Article] Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery. (2016)
  • Author(s): Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K
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• [Journal Article] Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese. (2016)
  • Author(s): Kasai S, Nishizawa D, Hasegawa J, Sato N, Tanioka F, Sugimura H, Ikeda K
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• [Journal Article] オピオイド感受性遺伝子の個体差について. (2016)
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  • NAID: 40021039483
• [Journal Article] Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese. (2016)
  • Author(s): Kasai S, Nishizawa D, Hasegawa J, Sato N, TanioF, Sugimura H, Ikeda K
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• [Journal Article] Association between AUTS2 haplotypes and alcohol dependence in a Japanese population. (2016)
  • Author(s): Narita S, Nagahori K, Nishizawa D, Yoshihara E, Kawai A, Ikeda K, Iwahashi K
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• [Journal Article] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy. (2015)
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• [Journal Article] Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. (2015)
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• [Journal Article] GIRKチャネルと薬物依存. (2015)
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• [Journal Article] JSNP Excellent Presentation Award for CINP2014: Reduced supraspinal nociceptive responses and distinct gene expression profile in CXBH recombinant inbred mice. (2015)
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• [Journal Article] JSNP Excellent Presentation Award for CINP2014: PCLOのSNPrs13438494は転写効率を制御することによりモノアミンの取り込み能を調節し, ヒト依存様行動と遺伝的関連性がある. (2015)
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• [Journal Article] JSNP Excellent Presentation Award for CINP2014: ゲノムワイド及び追加関連解析によるニコチン依存関連遺伝子多型の同定. (2015)
  • Author(s): 西澤大輔, 笠井慎也, 長谷川準子, 佐藤直美, 谷岡書彦, 長島誠, 氏家寛, 橋本亮太, 田中雅嗣, 椙村春彦, 池田和隆
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• [Journal Article] Specific roles of NMDA receptor subunits in mental disorders. (2015)
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• [Journal Article] Elucidating mechanisms for mental disorders: from specific molecules to pathology. (2015)
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• [Journal Article] Microphenotypes of mental disorders: a systematic approach to study disease mechanisms. (2015)
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• [Journal Article] Pathology and treatment of autism spectrum disorders (2015)
  • Author(s): 古田島(村上)浩子, 佐藤敦志, 池田和隆
  • Journal Title: Folia Pharmacologica Japonica Volume: 145 Issue: 4 Pages: 193-200
  • DOI: 10.1254/fpj.145.193
  • NAID: 130005061555
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed
• [Journal Article] Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements. (2015)
  • Author(s): Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K.
  • Journal Title: J Pharmacol Sci Volume: 127 Issue: 3 Pages: 391-393
  • DOI: 10.1016/j.jphs.2015.02.005
  • Peer Reviewed / Open Access
• [Journal Article] Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. (2015)
  • Author(s): Igari M, Shen H, Hagino Y, Fukushima S, Kasahara Y, Lesch K, Murphy D, George R Uhl, Ikeda K, Yaegashi N, Sora I
  • Journal Title: Behav Pharmacol Volume: 26 Issue: 1 and 2 - Special Issue Pages: 167-179
  • DOI: 10.1097/fbp.0000000000000120
  • Peer Reviewed
• [Journal Article] Association between experience of maltreatment and severity of drug addiction measured by the Addiction Severity Index among Japanese drug-dependent patients. (2015)
  • Author(s): Ogai Y, Senoo E, Chin Gardner F, Haraguchi A, Saito T, Morita N, Ikeda K
  • Journal Title: Int J Environ Res Public Health Volume: 12 Issue: 3 Pages: 2781-2792
  • DOI: 10.3390/ijerph120302781
  • Peer Reviewed / Open Access
• [Journal Article] Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. (2015)
  • Author(s): Yoshida K, Nishizawa D, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Journal Title: PLoS ONE Volume: 10 Issue: 1 Pages: e0116885-e0116885
  • DOI: 10.1371/journal.pone.0116885
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of Cholinergic System in Hyperactivity in Dopamine-Deficient Mice (2014)
  • Author(s): Hagino Y., Kasai S, Masayo F, Setogawa S, Yamaura H,Yanagihara D, Hashimoto M, Kobayashi K, Meltzer H, Ikeda K
  • Journal Title: Neuropsychopharmacology Volume: - Issue: 5 Pages: 1-10
  • DOI: 10.1038/npp.2014.295
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. (2014)
  • Author(s): Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K.
  • Journal Title: Mol Pain Volume: 10 Pages: 75-75
  • DOI: 10.1186/1744-8069-10-75
  • NAID: 120005549601
  • Peer Reviewed / Open Access
• [Journal Article] Association Between <i>KCNJ6</i> (<i>GIRK2</i>) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence (2014)
  • Author(s): Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K.
  • Journal Title: Journal of Pharmacological Sciences Volume: 126 Issue: 3 Pages: 253-263
  • DOI: 10.1254/jphs.14189FP
  • NAID: 130004700283
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed / Open Access
• [Journal Article] Haplotype analysis of GSK-3beta gene polymorphisms in bipolar disorder lithium responders and non-responders. (2014)
  • Author(s): Iwahashi K, Nishizawa D, Narita S, Numajiri M, Murayama O, Yoshihara E, Onozawa Y, Nagahori K, Fukamauchi F, Ikeda K, Ishigooka J
  • Journal Title: Clin Neuropharmacol Volume: 37 Issue: 4 Pages: 108-110
  • DOI: 10.1097/wnf.0000000000000039
  • Peer Reviewed / Open Access
• [Journal Article] Stress Sensitivity in Patients with Atopic Dermatitis in Relation to the Translocator Protein 18 kDa (TSPO) (2014)
  • Author(s): Koga M, Nakamoto Y, Nakamura K, Ikeda K, Yoshii M, Kawana S
  • Journal Title: Journal of Nippon Medical School Volume: 81 Issue: 3 Pages: 148-156
  • DOI: 10.1272/jnms.81.148
  • NAID: 130004147301
  • ISSN: 1345-4676, 1347-3409
  • Peer Reviewed / Open Access
• [Journal Article] Factors that affect intravenous patient-controlled analgesia for postoperative pain following orthognathic surgery for mandibular prognathism. (2014)
  • Author(s): Aoki Y, Yoshida K, Nishizawa D, Kasai S, Ichinohe T, Ikeda K, Fukuda K.
  • Journal Title: PLoS One Volume: 9 Issue: 6 Pages: e98548-e98548
  • DOI: 10.1371/journal.pone.0098548
  • Peer Reviewed / Open Access
• [Journal Article] Association between genetic polymorphism rs2952768, close to the METTL21A and CREB1 genes, and intellectual ability in healthy subjects (2014)
  • Author(s): Nishizawa D, Ohi K, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Takeda M, Ikeda K
  • Journal Title: Journal of Addiction Research & Therapy Volume: 5(2) Issue: 02 Pages: 1000178-1000178
  • DOI: 10.4172/2155-6105.1000178
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ノルエピネフリントランスポーター遺伝子多型とアルコール依存症との関連研究. (2014)
  • Author(s): 成田心, 永堀健太, 西澤大輔, 吉原英児, 川合厚子, 村山洋, 池田和隆, 岩橋和彦
  • Journal Title: 日本アルコール・薬物医学会雑誌 Volume: 49(6) Pages: 330-339
  • NAID: 40022403138
  • Peer Reviewed
• [Journal Article] 物質関連障害および嗜癖性障害群. (2014)
  • Author(s): 宮田久嗣, 樋口進, 廣中直行, 池田和隆, 伊豫雅臣, 小宮山徳太郎, 松本俊彦, 鈴木勉, 高田孝二, 和田清, 齋藤利和
  • Journal Title: 精神神経学雑誌 Volume: 116(11) Pages: 950-954
• [Journal Article] mTOR. (2014)
  • Author(s): 佐藤敦志, 池田和隆
  • Journal Title: 分子精神医学 Volume: 14(4) Pages: 50-51
• [Journal Article] 多様な依存性物質の作用に共通して影響する遺伝子多型. (2014)
  • Author(s): 西澤大輔, 池田和隆
  • Journal Title: 日本アルコール・薬物医学会雑誌 Volume: 49 Pages: 83-91
  • NAID: 40022402939
• [Journal Article] 喫煙行動と相関するオピオイド受容体関連遺伝子多型の解析. (2014)
  • Author(s): 笠井慎也, 西澤大輔, 長谷川準子, 佐藤直美, 谷岡書彦, 椙村春彦, 池田和隆
  • Journal Title: 日本神経精神薬理学会雑誌 Volume: 34 Pages: 53-54
• [Journal Article] 結節性硬化症モデルマウスの自閉症様行動におけるmTORシグナル系の関与. (2014)
  • Author(s): 佐藤敦志, 笠井慎也, 小林敏之, 高松幸雄, 樋野興夫, 池田和隆, 水口雅
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 34 Pages: 51-52
• [Presentation] Ketamine and NMDA receptor channels. (2018)
  • Author(s): Ikeda K
  • Organizer: TSBPN 2018 Spring Meeting
  • Int'l Joint Research / Invited
• [Presentation] Rapamycin treatment ameliorates impairment of social interaction in the mice treated prenatally with valproic acid. (2018)
  • Author(s): Kotajima H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
  • Organizer: 第8回 新潟大学脳研究所共同研究拠点国際シンポジウム
• [Presentation] Gene expression profile corresponding to autism-like behaviors in mouse models of tuberous sclerosis complex. (2018)
  • Author(s): Kashii H, Kasai S, Hagino Y, Sato A, Kotajima H, Tanaka M, Kobayashi T, Hino O, Oka A, Mizuguchi M, Ikeda K
  • Organizer: 第8回 新潟大学脳研究所共同研究拠点国際シンポジウム
• [Presentation] The relationship between stress and alcohol consumption in female mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall SF, Uhl GR, Ikeda K, Sora I
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Place of Presentation: Nusa Dua, Indonesia
  • Year and Date: 2017-04-28
  • Int'l Joint Research
• [Presentation] Genome-wide association study of pain sensitivity in cold pressor test. (2017)
  • Author(s): Takahashi K, Fukuda K, Nishizawa D, Kasai S, Kokita Y, Ichinohe T, Ikeda K
  • Organizer: 2017 IADR(International Association for Dental Research)General Session & Exhibition
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] The rewarding effect of methylphenidate on attention deficit/hyperactivity disorder model mice. (2017)
  • Author(s): Ikekubo Y, Ide S, Takamatsu Y, Takeda TC, Nagasawa S, Hua J, Ikeda K
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎ブリックホール・長崎新聞文化ホール（長崎県長崎市）
  • Year and Date: 2017-03-16
• [Presentation] 薬物感受性及び疾患脆弱性に関する全ゲノム関連解析結果データベースからのデータ抽出支援. (2017)
  • Author(s): 西澤大輔, 福田謙一, 林田眞和, 椙村春彦, 清水千佳子, 田中雅嗣, 池田和隆
  • Organizer: 平成28年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
  • Place of Presentation: 琵琶湖ホテル（滋賀県大津市）
  • Year and Date: 2017-02-07
• [Presentation] 注意欠如/ 多動性障害モデルマウスとしてのドパミントランスポーターノックアウトマウスの有用性. (2017)
  • Author(s): 井手聡一郎, 高松幸雄, 池窪結子, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
  • Organizer: 平成28年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
  • Place of Presentation: 琵琶湖ホテル（滋賀県大津市）
  • Year and Date: 2017-02-07
• [Presentation] 生理機能解析支援～薬理学的解析支援～. (2017)
  • Author(s): 森屋由紀, 西澤大輔, 井手聡一郎, 池田和隆
  • Organizer: 平成28年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
  • Place of Presentation: 琵琶湖ホテル（滋賀県大津市）
  • Year and Date: 2017-02-07
• [Presentation] 精神疾患病態におけるドーパミンシグナル関連マイクロエンドフェノタイプの解明. (2017)
  • Author(s): 池田和隆
  • Organizer: 新学術領域「マイクロ精神病態」班会議
  • Place of Presentation: 月岡ニューホテル冠月（新潟県新発田市）
  • Year and Date: 2017-01-22
• [Presentation] 次世代型薬物依存研究：神経ペプチド神経系の理解. (2017)
  • Author(s): 池田和隆
  • Organizer: 第52回日本アルコール・アディクション医学会学術総会
  • Invited
• [Presentation] Transcriptome profiling of dopamine-deficient mouse brain. (2017)
  • Author(s): Kasai S, Hagino Y, Fujita M, Kobayashi K, Ikeda K
  • Organizer: 第60回日本神経化学会大会
  • Invited
• [Presentation] 鎮痛薬適量予測式の構築と臨床応用技術の開発. (2017)
  • Author(s): 池田和隆
  • Organizer: 第４回包括的緩和医療科学学術研究会/第５回Tokyo疼痛緩和次世代研究会 合同研究会
  • Invited
• [Presentation] 疼痛緩和における“テーラーメイド治療”の実現に向けて. (2017)
  • Author(s): 井手聡一郎, 髙橋香央里, 西澤大輔, 福田謙一, 池田和隆
  • Organizer: 第11回日本緩和医療薬学会年会
  • Invited
• [Presentation] Molecular mechanisms underlying individual differences in pain and analgesic sensitivity. (2017)
  • Author(s): Kasai S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] The involvement of acetylcholine system in hyperactivity in dopamine-deficient (DD) mice. (2017)
  • Author(s): Ikeda K, Fujita M, Hagino Y, Kobayashi K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] NMDA receptor channel subunit GluN2D: A dark horse molecule in Neuropsychopharmacology. (2017)
  • Author(s): Ikeda K, Hagino Y, Ide S
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] mTOR阻害剤投与による胎生期バルプロ酸曝露マウスの自閉症様行動への影響. (2017)
  • Author(s): 村上浩子, 小林敏之, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 西藤泰昌, 高松幸雄, 内野茂夫, 池田和隆
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Circadian rhythm is maintained in dopamine-deficient mice. (2017)
  • Author(s): Fujita M, Hagino Y, Takeda TC, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikeda K
  • Organizer: The 56th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 56th Annual Meeting)
  • Int'l Joint Research
• [Presentation] ゲノムワイド関連解析（GWAS）による慢性疼痛感受性遺伝子多型の同定. (2017)
  • Author(s): 西澤大輔, 有田英子, 花岡一雄, 矢島直, 井関雅子, 加藤実, 小川節郎, 森山彩子, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
  • Organizer: 日本人類遺伝学会 第62回大会
• [Presentation] Sex differences in drinking behavior following stress in mu-opioid receptor knockout mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Hagino Y, Uhl GR, Ikeda K, Sora I
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] TANDに対するmTOR阻害剤の自覚的改善効果. (2017)
  • Author(s): 佐藤敦志, 池田和隆, 水口雅
  • Organizer: 第5回日本結節性硬化症学会学術総会
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil requirements during laparoscopic-assisted celectomy. (2017)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: ASHG2017 第67回米国人類遺伝学会
  • Int'l Joint Research
• [Presentation] 結節性硬化症モデルマウスにおける幼若期NMDA投与による点頭様発作の解析. (2017)
  • Author(s): 柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 岡明, 水口雅, 池田和隆
  • Organizer: 第51回日本てんかん学会年次学術集会
• [Presentation] インターロイキン-17A の一塩基多型と痛み関連表現型との関連解析. (2017)
  • Author(s): 大岡静衣, 西澤大輔, 長谷川準子, 高橋香央里, 中山京子, 江畑裕子, 福田謙一, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] ケタミンの抗うつ作用と認知機能障害におけるNMDA受容体GluN2Dサブユニットの役割. (2017)
  • Author(s): 井手聡一郎, 池窪結子, 橋本謙二, 三品昌美, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] muオピオイド受容体欠損マウスにおけるストレスとアルコール嗜好性に対する雌雄差の解析. (2017)
  • Author(s): 森屋由紀, 笠原好之, 萩野洋子, 池田和隆, 曽良一郎
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 日本人における N-methyl-D-aspartate receptor 2B subunit 遺伝子多型とアルコール依存症との関連研究. (2017)
  • Author(s): 成田心, 吉原英児, 西澤大輔, 川合厚子, 池田和隆, 岩橋和彦
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] ゲノムワイド関連解析（GWAS）による腹腔鏡補助下大腸切除術中レミフェンタニル投与速度に影響する遺伝子多型の同定. (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 山口茂樹, 笠井慎也, 長谷川準子, 福田謙一, 北村晶, 林田眞和, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 胎生期バルプロ酸曝露マウスの社会性行動障害のラパマイシン投与による改善. (2017)
  • Author(s): 古田島（村上）浩子, 小林敏之, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 西藤泰昌, 高松幸雄, 内野茂夫, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] Weaver変異型マウスにおける methamphetamineの報酬効果消失. (2017)
  • Author(s): 池窪結子, 井手聡一郎, 高松幸雄, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] Tsc2 ヘテロ欠損マウスの自閉症様行動に対するrapamycinの継続投与の効果とその副作用の検討. (2017)
  • Author(s): 柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 水口雅, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動とトリプトファン欠乏食による改善効果. (2017)
  • Author(s): 田中美歩, 佐藤敦志, 笠井慎也, 萩野洋子, 古田島浩子, 柏井洋文, 西藤泰昌, 稲垣真澄, 曽良一郎, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 各種自発行動におけるドーパミン依存性の解析. (2017)
  • Author(s): 藤田雅代, 萩野洋子, Takeda T, 笠井慎也, 高松幸雄, 池田和隆
  • Organizer: 第52回日本アルコール・アディクション医学会学術総会
• [Presentation] 外側視床下部脳内自己刺激におけるオピオイド神経系とドパミン神経系の役割. (2017)
  • Author(s): 井手聡一郎, 高橋雄大, 高松幸雄, Uhl GR, 曽良一郎, 池田和隆
  • Organizer: 第37回鎮痛薬・オピオイドペプチドシンポジウム
• [Presentation] Association study of a candidate genetic variant with the development of taxane-induced peripheral neuropathy. (2017)
  • Author(s): Tanabe Y, Nishizawa D, Hasegawa J, Ikeda K, Shimomura A, Takano T, Shimizu C
  • Organizer: 第15回日本臨床腫瘍学会学術集会
• [Presentation] The effects of chronic stress on alcohol consumption in mu-opioid receptor knockout mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: International Narcotics Research Conference 2017 (INRC2017)
  • Int'l Joint Research
• [Presentation] Stress-induced alcohol drinking in mice lacking mu-opioid receptors. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: 26th Annual Meeting of the International Behavioral Neuroscience Society (IBNS2017)
  • Int'l Joint Research
• [Presentation] 遺伝子多型と疼痛感受性・オピオイド感受性. (2017)
  • Author(s): 林田眞和, 福田謙一, 西澤大輔, 池田和隆
  • Organizer: 日本麻酔科学会第64回学術集会
• [Presentation] Inhibition of mTOR improves autism-like behaviors in mice in utero exposed to valproic acid. (2017)
  • Author(s): Kotajima-Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Rapamycin treatment of impaired social behavior in adolescent Tsc2+/－mice. (2017)
  • Author(s): Kashii H, Hagino Y, Kasai S, Kotajima H, Sato A, Kobayashi T, Hino O, Mizuguchi M, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Association between genetic polymorphisms in Cav2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery. (2017)
  • Author(s): Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Associations between polymorphisms close to the cAMP responsive element binding protein 1 (CREB1) gene and the activating transcription factor 2 (ATF2) gene and fentanyl sensitivity. (2017)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Single nucleotide polymorphisms in the 5’flanking region of interleukin-17A gene significantly associate with pain sensitivity. (2017)
  • Author(s): Ohka S, Nishizawa D, Hasegawa J, Takahashi K, Nakayama K, Ebata Y, Fukuda K, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Genetic polymorphisms in the orexin system (focusing on a polymorphism associated with nicotine dependence). (2017)
  • Author(s): Nishizawa D, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Association of Proopioimeranocortin gene polymorphism with vulnerability to alcohol dependence in Japanese. (2017)
  • Author(s): Kasai S, Nishizawa D, Higuchi S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy. (2017)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] The relationship between stress and alcohol consumption in female mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Distinct roles of opioid and dopamine systems in lateral hypothalamic intracranial self-stimulation. (2016)
  • Author(s): Ikeda K, Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I
  • Organizer: The 55th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 55th Annual Meeting)
  • Place of Presentation: Hollywood, USA
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] 本邦の病院小児科におけるTSC患者の診療実態調査. (2016)
  • Author(s): 佐藤敦志, 池田和隆, 水口雅
  • Organizer: 第4回日本結節性硬化症学会学術総会
  • Place of Presentation: 大阪大学銀杏会館（大阪府吹田市）
  • Year and Date: 2016-11-12
• [Presentation] ドーパミン欠乏マウスにおける異常性行動の脳内メカニズム. (2016)
  • Author(s): 藤田雅代, Takeda TC, 萩野洋子, 笠井慎也, 橋本款, 小林和人, 池田和隆
  • Organizer: 第51回日本アルコール・アディクション医学会学術総会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2016-10-07
• [Presentation] 脳内自己刺激法を用いた薬物依存性解析および報酬系神経回路の解析. (2016)
  • Author(s): 井手聡一郎, 池田和隆
  • Organizer: 第51回日本アルコール・アディクション医学会学術総会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果. (2016)
  • Author(s): 池窪結子, 井手聡一郎, 高松幸雄, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
  • Organizer: 第51回日本アルコール・アディクション医学会学術総会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2016-10-07
• [Presentation] Genetic mechanisms underlying individual differences in sensitivity to pain and opioids. (2016)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-09-27
  • Int'l Joint Research / Invited
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy. (2016)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A,Hayashida M, Ikeda K
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-09-27
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy. (2016)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: 16th World Congress on Pain（第16回世界疼痛学会）
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果. (2016)
  • Author(s): 池窪結子, 井手聡一郎, 高松幸雄, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
  • Organizer: 平成28年度新学術領域研究「学術研究支援基盤形成【先端モデル動物支援プラットフォーム】」若手支援技術講習会
  • Place of Presentation: 蓼科グランドホテル滝の湯（長野県茅野市）
  • Year and Date: 2016-09-16
• [Presentation] 性差の観点からみたストレスによるアルコール摂取行動変化とmuオピオイド神経伝達系の関与. (2016)
  • Author(s): 森屋由紀, 笠原好之, Hall FS, Uhl GR, 池田和隆, 曽良一郎
  • Organizer: 平成28年度新学術領域研究「学術研究支援基盤形成【先端モデル動物支援プラットフォーム】」若手支援技術講習会
  • Place of Presentation: 蓼科グランドホテル滝の湯（長野県茅野市）
  • Year and Date: 2016-09-15
• [Presentation] 鎮痛薬感受性と関連するオピオイドペプチド遺伝子多型の解析. (2016)
  • Author(s): 笠井慎也, 西澤大輔, 林田眞和, 長島誠, 加藤良二, 池田和隆
  • Organizer: 第3回包括的緩和医療科学学術研究会・第4回Tokyo疼痛緩和次世代研究会 合同研究会
  • Place of Presentation: TKPガーデンシティ永田町（東京都千代田区）
  • Year and Date: 2016-08-28
• [Presentation] Cav2.3(R型)電位依存性Ca2+チャネル遺伝子多型と鎮痛薬感受性との関連. (2016)
  • Author(s): 井手聡一郎, 西澤大輔, 福田謙一, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
  • Organizer: 第36回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 北海道大学薬学部（北海道札幌市）
  • Year and Date: 2016-08-20
• [Presentation] タバコ・ニコチン依存に影響を及ぼすオピオイド受容体関連遺伝子. (2016)
  • Author(s): 笠井慎也, 西澤大輔, 佐藤直美, 谷岡書彦, 椙村春彦, 池田和隆
  • Organizer: 第36回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 北海道大学薬学部（北海道札幌市）
  • Year and Date: 2016-08-20
• [Presentation] 遺伝子多型と術後オピオイド. (2016)
  • Author(s): 池田和隆
  • Organizer: 第6回術後疼痛懇話会
  • Place of Presentation: 青蓮会館（京都府京都市）
  • Year and Date: 2016-07-29
  • Invited
• [Presentation] NMDA receptor channel GluN2D subunit as a target molecule for medicines for mental disorders. (2016)
  • Author(s): Ikeda K, Hagino Y, Ide S
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-21
  • Invited
• [Presentation] 喫煙関連遺伝子多型の同定とその機能解析. (2016)
  • Author(s): 池田和隆, 西澤大輔, 笠井慎也, 高松幸雄, 萩野洋子, 椙村春彦
  • Organizer: 公益財団法人喫煙科学研究財団 第31回平成27年度助成研究発表会
  • Place of Presentation: 京王プラザ（東京都新宿区）
  • Year and Date: 2016-07-20
• [Presentation] Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. (2016)
  • Author(s): Nishizawa D, Yoshida K, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath, UK
  • Year and Date: 2016-07-14
  • Int'l Joint Research
• [Presentation] Increased number of glial and neuronal cells in the periaqueductal gray matter (PAG) of mu-opioid receptor knockout mice. (2016)
  • Author(s): Sasaki K, Sora I, Kasahara Y, Ikeda K, Hall FS, Uhl GR, Kawashima R
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath, UK
  • Year and Date: 2016-07-11
  • Int'l Joint Research
• [Presentation] Sex differences in voluntary drinking by mu-opioid receptor knockout mice following early stress. (2016)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath, UK
  • Year and Date: 2016-07-11
  • Int'l Joint Research
• [Presentation] オピオイド感受性関連遺伝子多型の同定とテーラーメイド疼痛治療の開始. (2016)
  • Author(s): 池田和隆, 西澤大輔, 福田謙一, 林田眞和
  • Organizer: 日本ペインクリニック学会第50回大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-08
  • Invited
• [Presentation] The abolished rewarding effect of methylphenidate in dopamine transporter knockout mice, a model for attention deficit/hyperactivity disorder. (2016)
  • Author(s): Ide S, Takamatsu Y, Ikekubo Y, Takeda TC, Nagasawa S, Hua J, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Transcriptome analysis in Tsc2 heterozygous knockout mice. (2016)
  • Author(s): Kasai S, Sato A, Kashii H, Kobayashi T, Hino O, Mizuguchi M, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy. (2016)
  • Author(s): Nishizawa D, Mieda T, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] c-Fos immunoreactivity in hypoactive and hyperactive Dopamine-deficient mice. (2016)
  • Author(s): Takeda TC, Fujita M, Hagino Y, Mizuguchi M, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery. (2016)
  • Author(s): Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Association between the rs7583431single-nucleotide polymorphism close to the activating transcription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test. (2016)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Therapeutic effects of cholinergic drug on mechanical allodynia in the mouse partial sciatic nerve ligation model. (2016)
  • Author(s): Yamanishi Y, Takamatsu Y, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Effects of chronic tryptophan depletion on autism spectrum disorder like behaviors in serotonin transporter knockout and heterozygous mice. (2016)
  • Author(s): Tanaka M, Sato A, Hagino Y, Sora I, Murphy D, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-04
  • Int'l Joint Research
• [Presentation] Methamphetamine induced changes of monoamine neurotransmission in 5-HT1B KO mice. (2016)
  • Author(s): Moriya Y, Kasahara Y, Hagino Y, Hall FC, Hen R, Ikeda K, Uhl GR, Sora I
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-04
  • Int'l Joint Research
• [Presentation] Genetic polymorphisms commonly associated with sensitivity to addictive substances. (2016)
  • Author(s): Ikeda K, Nishizawa D, Fukuda K, Hayashida M, Higuchi S, Sugimura H, Sora I
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-04
  • Int'l Joint Research / Invited
• [Presentation] レミフェンタニル・プロポフォール全静脈麻酔中にフェンタニルの追加投与を必要とした症例の遺伝子多型. (2016)
  • Author(s): 髙橋香央里, 福田謙一, 西澤大輔, 笠井慎也, 須野学, 髙北義彦, 一戸達也, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-03
• [Presentation] SCN9A遺伝子の一塩基多型rs6746030のマイナーアレル保有者に対する術後鎮痛法の、相関研究および電気生理学的研究に基づく検討. (2016)
  • Author(s): 天野功二郎, 堀下貴文, 西澤大輔, 三枝勉, 辻田美紀, 長島誠, 加藤良二, 長谷川準子, 北村晶, 川崎貴士, 林田眞和, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-03
• [Presentation] Activating transcription factor 2(ATF2)遺伝子近傍の遺伝子多型rs7583431と冷水誘発疼痛試験におけるフェンタニルの鎮痛効果との関連. (2016)
  • Author(s): 青木謙典, 西澤大輔, 吉田香織, 長谷川準子, 笠井慎也, 髙橋香央里, 髙北義彦, 一戸達也, 林田眞和, 福田謙一, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-03
• [Presentation] マウスでの坐骨神経部分結紮後のアロディニアに対するコリン系薬物の治療効果. (2016)
  • Author(s): 山西嘉晴, 高松幸雄, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-03
• [Presentation] 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果の変化. (2016)
  • Author(s): 井手聡一郎, 高松幸雄, 池窪結子, 武田大志クラーク, 長澤セーラ, Hua J, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-03
• [Presentation] 低活動と多動時のドーパミン欠乏マウスのc-Fos免疫反応性. (2016)
  • Author(s): Takeda TC, 藤田雅代, 萩野洋子, 水口雅, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-03
• [Presentation] セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動とトリプトファン欠乏食による改善効果. (2016)
  • Author(s): 田中美歩, 佐藤敦志, 萩野洋子, 曽良一郎, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-03
• [Presentation] 神経精神薬理学の動向：国際連携と学術会議の視点から. (2016)
  • Author(s): 池田和隆, 山脇成人
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-03
  • Invited
• [Presentation] ゲノムワイド関連解析（GWAS）による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定. (2016)
  • Author(s): 西澤大輔, 三枝勉, 中川秀之, 辻田美紀, 今西宏和, 寺尾和久, 吉川博昭, 伊藤一志, 天野功二郎, 田代浄, 石井利昌, 有山淳, 山口茂樹, 笠井慎也, 長谷川準子, 中山京子, 江畑裕子, 池田和隆, 北村晶, 林田眞和
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-02
• [Presentation] 日本人におけるAUTS2遺伝子多型rs6943555と人格特性との関連研究. (2016)
  • Author(s): 成田心, 岩橋和彦, 吉原英児, 西澤大輔, 石郷岡純, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-02
• [Presentation] 健常者におけるストレス反応の性差：トランスローケーター蛋白質（TSPO）、コルチゾール、状態・特性不安検査（STAI）による検討. (2016)
  • Author(s): 中本百合江, 中村和彦, 池田和隆, 吉井光信
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-02
• [Presentation] オピオイド投与中の神経因性疼痛患者へのＥＣＴによる鎮痛効果. (2016)
  • Author(s): 岩田健, 小林雪乃, 米良仁志, 土井永史, 諏訪浩, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-02
• [Presentation] インターロイキン17Aが発達障害、精神疾患等に及ぼす影響について. (2016)
  • Author(s): 大岡静衣, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-02
• [Presentation] 知的障害と妊娠期における物質曝露. (2016)
  • Author(s): 古田島(村上)浩子, 池田和隆, 内野茂夫
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-02
  • Invited
• [Presentation] オピオイド不適切使用の評価と中止法において遺伝子検査が貢献する可能性. (2016)
  • Author(s): 池田和隆, 西澤大輔, 林田眞和, 福田謙一
  • Organizer: 第21回日本緩和医療学会学術大会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-06-18
  • Invited
• [Presentation] 緩和医療領域における遺伝子診断とテーラーメード医療の現状と将来展望. (2016)
  • Author(s): 池田和隆
  • Organizer: 第10回日本緩和医療薬学会年会
  • Place of Presentation: アクトシティ浜松コングレスセンター（静岡県浜松市）
  • Year and Date: 2016-06-05
  • Invited
• [Presentation] 統合失調症と依存性薬物. (2016)
  • Author(s): 池田和隆
  • Organizer: 第41回新潟精神医学懇話会
  • Place of Presentation: ホテル日航新潟（新潟県新潟市）
  • Year and Date: 2016-05-31
  • Invited
• [Presentation] Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing orthognathic surgery. (2016)
  • Author(s): Muraoka W, Saisu H, Sato H, Usuda S, Inoue M, Ochiai S, Nishizawa D, Hasegawa J, Kasai S, Nakagawa T, Wajima K, Fukuda K, Ikeda K
  • Organizer: American Academy of Orofacial Pain
  • Place of Presentation: Lake Buena Vista, USA
  • Year and Date: 2016-04-15
  • Int'l Joint Research
• [Presentation] Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing orthognathic surgery. (2016)
  • Author(s): Muraoka W, Saisu H, Sato H, Usuda S, Inoue M, Ochiai S, Nishizawa D, Hasegawa J, Kasai S, Nakagawa T, Wajima K, Fukuda K, Ikeda K
  • Organizer: American Academy of Orofacial Pain
  • Place of Presentation: Florida, USA
  • Year and Date: 2016-04-14
  • Int'l Joint Research
• [Presentation] ドーパミンの欠乏時と過剰時の異常行動：遺伝子改変マウスの解析. (2016)
  • Author(s): 池田和隆
  • Organizer: 第23回多摩キャンパス神経カンファレンス
  • Place of Presentation: 東京都立神経病院（東京都府中市）
  • Year and Date: 2016-03-11
• [Presentation] Therapeutic effects of cholinergic drugs on mechanical allodynia in the mouse partial sciatic nerve ligation model. (2016)
  • Author(s): Yamanishi Y, Takamatsu Y, Ikeda K
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜会議センター（神奈川県横浜市）
  • Year and Date: 2016-03-10
• [Presentation] 喫煙関連遺伝子多型の同定とのその機能解析. (2016)
  • Author(s): 池田和隆
  • Organizer: 喫煙科学特定研究検討会
  • Place of Presentation: 東海大学 校友会館（東京都千代田区）
  • Year and Date: 2016-01-26
• [Presentation] NMDA receptor GluN2D subunit is indispensable in phencyclidine (PCP) effects. (2015)
  • Author(s): Ikeda K, Hagino Y, Kasai S, Yamamoto H, Mishina M
  • Organizer: The 54th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 54th Annual Meeting)
  • Place of Presentation: Hollywood, USA
  • Year and Date: 2015-12-07
  • Int'l Joint Research
• [Presentation] 胎生期バルプロ酸曝露による発達障害モデルマウスにおけるケモカインCCL5の発見亢進. (2015)
  • Author(s): 村上(古田島)浩子, 檜山(和賀)央子, 茂木悠, 鳩山拓史, 瀧口皓大, 関健太, 池田和隆, 内野茂夫
  • Organizer: 第38回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] Genome-wide association study identifies a potent locus associated with human opioid sensitivity. (2015)
  • Author(s): Nishizawa D, Ikeda K
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Genetic association with smoking/tobacco use in Japanese. (2015)
  • Author(s): Kasai S, Sugimura H, Ikeda K
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-21
  • Int'l Joint Research
• [Presentation] Involvement of cholinergic system in hyperactivity in dopamine deficient mice. (2015)
  • Author(s): Fujita M, Hagino Y, Kasai S, Setogawa S, Yamaura H, Yanagihara D, Hashimoto M, Kobayashi K, Meltzer HY, Ikeda K
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] Behavioral and chemokine gene expression analyses in the mice exposed in utero to valproic acid. (2015)
  • Author(s): Kotajima-Murakami H, Nakamura Y, Tsuchiya A, Suzuki E, Waga C, Ikeda K, Uchino S
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements. (2015)
  • Author(s): Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence. (2015)
  • Author(s): Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] Gene expression profile exhibits abnormal responses to nociceptive stimuli in the recombinant inbred mouse strain CXBH. (2015)
  • Author(s): Kasai S, Ikeda K
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] transient receptor potential subfamily C member 3 (TRPC3) 遺伝子近傍の遺伝子多型rs1465040と外科手術後における鎮痛薬必要量との関連. (2015)
  • Author(s): 青木謙典, 西澤大輔, 長谷川準子, 笠井慎也, 吉田香織, 髙北義彦, 一戸達也, 長島誠, 加藤良二, 佐藤泰雄, 田上惠, 林田眞和, 福田謙一, 池田和隆
  • Organizer: 第35回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 和歌山県立情報交流センターBig・U（和歌山県田辺市）
  • Year and Date: 2015-10-16
• [Presentation] ドーパミン欠乏時の異常行動とそのメカニズム. (2015)
  • Author(s): 池田和隆, 藤田雅代, 萩野洋子
  • Organizer: 平成27年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-10-13
• [Presentation] Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence. (2015)
  • Author(s): Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K
  • Organizer: 65th Annual Meeting of the American Society of Human Genetics
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] ゲノムワイド関連解析（GWAS）によるオピオイド感受性関連遺伝子多型の同定とその臨床応用. (2015)
  • Author(s): 西澤大輔, 池田和隆
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-26
• [Presentation] XBP1 遺伝子多型とアルコール依存症および不安関連人格特性との関連研究. (2015)
  • Author(s): 成田心, 岩橋和彦, 吉原英児, 川合厚子, 西澤大輔, 池田和隆, 石郷岡純
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] 内臓痛の有無で逆転する、R 型電位依存性カルシウムチャネルの一塩基多型rs3845446 が術後のオピオイド必要量に与える影響. (2015)
  • Author(s): 天野功二郎, 三枝勉, 北村晶, 林田眞和, 西澤大輔, 池田和隆
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] Tsc2 ヘテロ遺伝子欠損による脳内遺伝子発現変化の網羅的解析. (2015)
  • Author(s): 笠井慎也, 佐藤敦志, 柏井洋文, 小林敏之, 樋野興夫, 水口雅, 池田和隆
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] GluN2D サブユニット欠損による引きこもりアンヘドニアモデルマウスの行動薬理学的解析. (2015)
  • Author(s): 山本秀子, 亀ヶ谷悦子, 萩野洋子, 松澤真彩, 三品昌美, 山本敏文, 池田和隆
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] APT受容体P2X7サブタイプ遺伝子多型と疼痛及び鎮痛薬感受性との相関. (2015)
  • Author(s): 井手聡一郎, 西澤大輔, 福田謙一, 笠井慎也, 長谷川準子, 林田眞和, 南雅文, 池田和隆
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] 胎生期バルプロ酸曝露マウスにおける行動異常とケモカインの脳内発現. (2015)
  • Author(s): 古田島浩子, 中村泰子, 和賀央子, 鳩山拓史, 茂木悠, 関健太, 瀧口皓大, 池田和隆, 内野茂夫
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動. (2015)
  • Author(s): 田中美歩, 佐藤敦志, 萩野洋子, 曽良一郎, 池田和隆
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] 精神疾患病態におけるドーパミンシグナル関連マイクロエンドフェノタイプの解明. (2015)
  • Author(s): 池田和隆
  • Organizer: 新学術領域「マイクロ精神病態」班会議
  • Place of Presentation: 八ヶ岳ロイヤルホテル（山梨県北杜市）
  • Year and Date: 2015-08-30
• [Presentation] GIRK channel as a candidate target for pharmacotherapy of drug and alcohol dependence. (2015)
  • Author(s): Ikeda K, Sugaya N, Ogai Y, Nishizawa D
  • Organizer: 4th APSAAR / 5th IDARS Conference
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-08-19
  • Int'l Joint Research
• [Presentation] テーラーメイド疼痛治療の有用性の検証状況. (2015)
  • Author(s): 池田和隆
  • Organizer: 緩和医療薬学研究会／第3回Tokyo 疼痛緩和次世代研究会
  • Place of Presentation: 星薬科大学（東京都品川区）
  • Year and Date: 2015-08-06
• [Presentation] APT受容体P2X7サブタイプ遺伝子多型と疼痛及び鎮痛薬感受性との相関. (2015)
  • Author(s): 井手聡一郎, 西澤大輔, 福田謙一, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
  • Organizer: 緩和医療薬学研究会／第3回Tokyo 疼痛緩和次世代研究会
  • Place of Presentation: 星薬科大学（東京都品川区）
  • Year and Date: 2015-08-05
• [Presentation] Involvement of cholinergic system in hyperactivity in dopamine-deficient mice. (2015)
  • Author(s): Ikeda K, Hagino Y, Kasai S, Fujita M, Setogawa S, Yamaura H, Yanagihara D, Hashimoto M, Kobayashi K
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-07-30
• [Presentation] 喫煙関連遺伝子多型の同定とその機能解析. (2015)
  • Author(s): 池田和隆, 西澤大輔, 笠井慎也, 高松幸雄, 萩野洋子, 椙村春彦
  • Organizer: 公益財団法人喫煙科学研究財団 平成26年度助成研究発表会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-07-23
• [Presentation] 慢性疼痛の個別化薬物療法へ向けた研究. (2015)
  • Author(s): 池田和隆
  • Organizer: 第23回クリニカルファーマシーシンポジウム 医療薬学フォーラム2015
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-07-05
  • Invited
• [Presentation] Critical role of NMDA receptor GluN2D subunit in phencyclidine effects. (2015)
  • Author(s): Ikeda K, Hagino Y, Kasai S, Yamamoto H
  • Organizer: Association for the Study of Neurons and Diseases the 10th International Conference for Neurons and Brain Disease
  • Place of Presentation: Xi’an China
  • Year and Date: 2015-06-23
  • Int'l Joint Research
• [Presentation] テーラーメイド疼痛治療法の開発と実施. (2015)
  • Author(s): 池田和隆
  • Organizer: ゲノム創薬・医療フォーラム第4回 談話会.
  • Place of Presentation: 東京大学医科学研究所（東京都港区）
  • Year and Date: 2015-06-09
  • Invited
• [Presentation] Genetic mechanisms underlying individual differences in opioid sensitivity in Japanese. (2015)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: WPA Regional Congress OSAKA Japan 2015
  • Place of Presentation: 大阪国際会議場・リーガロイヤルホテル大阪（大阪府大阪市）
  • Year and Date: 2015-06-05
  • Int'l Joint Research
• [Presentation] Genetic mechanisms underlying individual differences in opioid sensitivity in Japanese. (2015)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: WPA Regional Congress OSAKA Japan 2015
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-06-05
• [Presentation] 疼痛感受性やオピオイド感受性に影響を及ぼす遺伝子多型. (2015)
  • Author(s): 林田眞和, 福田謙一, 西澤大輔, 池田和隆
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-05-30
• [Presentation] 痛みの遺伝子多型についての基礎研究と臨床研究. (2015)
  • Author(s): 池田和隆
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] R型電位依存性カルシウムチャネル遺伝子の一塩基多型rs3845446は、内臓性炎症性疼痛の有無により、体性炎症性疼痛に対する術後鎮痛薬必要量に相反する影響を与える. (2015)
  • Author(s): 天野功二郎, 三枝勉, 北村晶, 西澤大輔, 池田和隆, 林田眞和
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-28
• [Presentation] ラミニンbeta3遺伝子 (LAMB3) の一塩基多型rs2076222は、腹腔鏡補助下大腸切除術後のPCAフェンタニル必要量に影響する. (2015)
  • Author(s): 林田眞和, 三枝勉, 西澤大輔, 池田和隆, 有山淳, 北村晶
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-28
• [Presentation] 疼痛感受性やオピオイド感受性に影響を及ぼす遺伝子多型. (2015)
  • Author(s): 林田眞和, 福田謙一, 西澤大輔, 池田和隆
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-28
• [Presentation] 遺伝子多型判定に基づくオピオイド性鎮痛薬必要量予測式の構築と検証. (2015)
  • Author(s): 吉田香織, 福田謙一, 林田眞和, 西澤大輔, 池田和隆, 一戸達也
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-28
• [Presentation] R型電位依存性カルシウムチャネル遺伝子の一塩基多型rs3845446は、内臓性炎症性疼痛の有無により、体性炎症性疼痛に対する術後鎮痛薬必要量に相反する影響を与える. (2015)
  • Author(s): 天野功二郎, 三枝勉, 北村晶, 西澤大輔, 池田和隆, 林田眞和
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-28
• [Presentation] ラミニンbeta3遺伝子 (LAMB3) の一塩基多型rs2076222は、腹腔鏡補助下大腸切除術後のPCAフェンタニル必要量に影響する. (2015)
  • Author(s): 林田眞和, 三枝勉, 西澤大輔, 池田和隆, 有山淳, 北村晶
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-05-28
• [Presentation] 遺伝子多型判定に基づくオピオイド性鎮痛薬必要量予測式の構築と検証. (2015)
  • Author(s): 吉田香織, 福田謙一, 林田眞和, 西澤大輔, 池田和隆, 一戸達也
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-05-28
• [Presentation] 痛みの遺伝子多型についての基礎研究と臨床研究. (2015)
  • Author(s): 池田和隆
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] Tsc2 haploinsufficiency causes more severe autistic-like behavioral deficit than Tsc1 in mice. (2015)
  • Author(s): Sato A, Tanaka M, Takamatsu Y, Kasai S, Kobayashi T, Hino O, Ikeda K, Mizuguchi M
  • Organizer: 13th Asian and Oceania Congress of Child Neurology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] 疾患モデルとしてのマウスとドーパミン関連遺伝子改変マウスの解析. (2015)
  • Author(s): 笠井慎也, 萩野洋子, 池田和隆
  • Organizer: 第10回日本統合失調症学会
  • Place of Presentation: 都市センターホテル（東京都千代田区）
  • Year and Date: 2015-03-27
• [Presentation] メチルフェニデート等による依存性の形成機序の解明. (2015)
  • Author(s): 池田和隆
  • Organizer: 厚生労働科学研究費補助金（医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業）「違法ドラッグ等の薬物依存のトレンドを踏まえた病態の解明と診断・治療法の開発」平成26年度研究成果報告会
  • Place of Presentation: 星薬科大学（東京都品川区）
  • Year and Date: 2015-03-05
• [Presentation] 喫煙関連遺伝子多型の同定とその機能解析. (2015)
  • Author(s): 池田和隆
  • Organizer: 財団法人喫煙科学研究財団, 特定研究「ヒト発がんと遺伝子多型、喫煙との関連」中間検討会
  • Place of Presentation: スクワール麹町（東京都千代田区）
  • Year and Date: 2015-01-30
• [Presentation] Specific regions display altered grey matter volume in mu-opioid receptor knockout mice: mri voxel-based morphometry. (2014)
  • Author(s): Sora I, Sasaki K, Sumiyoshi A, Nonaka H, Kasahara Y, Ikeda K, Hall FS, Uhl GR, Watanabe M, Kawashima R
  • Organizer: The 53rd Annual Meeting of American College of Neuropsychopharmacology (ACNP 53rd Annual Meeting)
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2014-12-07 – 2014-12-11
• [Presentation] 歯科とゲノム医療. (2014)
  • Author(s): 池田和隆
  • Organizer: 第4回臨床ゲノム医療学会“東京水道橋大会”
  • Place of Presentation: 東京歯科大学水道橋校舎新館血脇記念ホール（東京都千代田区）
  • Year and Date: 2014-11-30
  • Invited
• [Presentation] アジアにおける神経精神薬理学の発展と日本への波及効果. (2014)
  • Author(s): 池田和隆
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会合同年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2014-11-22
• [Presentation] GSK3beta遺伝子多型と若年者の喫煙習慣との関連. (2014)
  • Author(s): 永堀健太, 岩橋和彦, 成田心, 沼尻真貴, 吉原英児, 西澤大輔, 池田和隆, 石郷岡純
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会合同年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2014-11-21
• [Presentation] ノルエピネフリントランスポーター遺伝子多型とアルコール依存症との関連研究. (2014)
  • Author(s): 成田心, 岩橋和彦, 永堀健太, 吉原英児, 西澤大輔, 川合厚子, 池田和隆, 石郷岡純
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会合同年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2014-11-21
• [Presentation] ドーパミン欠損マウスの多動におけるアセチルコリン神経の関与. (2014)
  • Author(s): 萩野洋子, 笠井慎也, 藤田雅代, 瀬戸川将, 山浦洋, 柳原大, 橋本款, 小林和人, 池田和隆
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会合同年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2014-11-21
• [Presentation] ドーパミン欠乏マウスモデルを用いたドーパミン非存在下の運動亢進メカニズムの解析. (2014)
  • Author(s): 藤田雅代, 萩野洋子, 笠井慎也, 橋本款, 小林和人, 池田和隆
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会合同年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2014-11-21
• [Presentation] ドーパミントランスポーター欠損マウスにおけるメチルフェニデートとアトモキセチンの週齢別効果. (2014)
  • Author(s): 長澤セーラ幸恵, 高松幸雄, 佐藤敦志, 柏井洋文, 久保有美子, 水口雅, 曽良一郎, 池田和隆
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会合同年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2014-11-21
• [Presentation] Differences in responsiveness between methamphetamine, nisoxetine and methylphenidate may reflect specific developmental characteristics in juvenile DAT KO mice. (2014)
  • Author(s): Kubo Y, Kasahara Y, Arime Y, Hall FS, Takamatsu Y, Ikeda K, Uhl GR, Sora I, Tomita H
  • Organizer: Society for Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy. (2014)
  • Author(s): Nishizawa D, Kobayashi D, Takasaki Y, Kasai S, Aoki Y, Hasegawa J, Kakizawa T, Ikeda K, Fukuda K
  • Organizer: The American Society of Human Genetics 64th Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-10-19
• [Presentation] Prediction of relapse using implicit association test to Japanese alcohol dependence inpatients. (2014)
  • Author(s): Ogai Y, Aikawa Y, Yumoto Y, Umeno M, Sakakibara S, Kadowaki A, Saito T, Morita N, Ikeda K
  • Organizer: ISAM2014
  • Place of Presentation: パシフィコ横浜会議センター（神奈川県横浜市）
  • Year and Date: 2014-10-06
• [Presentation] A randomized and rater-blinded study of the effect of ifenprodil on alcohol reuse in patients with alcohol dependence. (2014)
  • Author(s): Sugaya N, Ogai Y, Aikawa Y, Yumoto Y, Takahama M, Tanaka M, Haraguchi A, Umeno M, Ikeda K
  • Organizer: ISAM2014
  • Place of Presentation: パシフィコ横浜会議センター（神奈川県横浜市）
  • Year and Date: 2014-10-06
• [Presentation] ゲノムワイド関連解析によるオレキシン2 受容体遺伝子多型Val308Ile とニコチン依存との関連の同定. (2014)
  • Author(s): 西澤大輔, 笠井慎也, 佐藤直美, 谷岡書彦, 長島誠, 氏家寛, 橋本亮太, 田中雅嗣, 椙村春彦, 池田和隆
  • Organizer: 平成26年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: パシフィコ横浜会議センター（神奈川県横浜市）
  • Year and Date: 2014-10-03
• [Presentation] ニコチン依存脆弱性に影響を及ぼすオピオイド受容体関連遺伝子. (2014)
  • Author(s): 笠井慎也, 椙村春彦, 池田和隆
  • Organizer: 平成26年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: パシフィコ横浜会議センター（神奈川県横浜市）
  • Year and Date: 2014-10-03
• [Presentation] Involvement of NMDA receptor GluN2D subunit in phencyclidine effects. (2014)
  • Author(s): Ikeda K, Hagino Y, Kasai S, Yamamoto H
  • Organizer: ISAM2014
  • Place of Presentation: パシフィコ横浜会議センター（神奈川県横浜市）
  • Year and Date: 2014-10-03
  • Invited
• [Presentation] 依存性物質の作用機序解明と医療応用. (2014)
  • Author(s): 池田和隆
  • Organizer: 平成26年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: パシフィコ横浜会議センター（神奈川県横浜市）
  • Year and Date: 2014-10-03
  • Invited
• [Presentation] Genetic deprivation of GluN2D subunit induced impairments of emotion and social recognition. (2014)
  • Author(s): Yamamoto H, Kamegaya E, Hagino Y, Takamatsu Y, Mishina M, Yamamoto T, Ikeda K
  • Organizer: 第57回日本神経化学会
  • Place of Presentation: 奈良県文化会館（奈良県奈良市）
  • Year and Date: 2014-09-30
• [Presentation] メチルフェニデートによるドーパミントランスポーター欠損マウスのADHD様行動の改善は発達段階によって異なる. (2014)
  • Author(s): 久保有美子, 笠原好之, 富田博秋, 有銘預世布, 高松幸雄, 池田和隆, 曽良一郎
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-13
• [Presentation] アルコール依存症入院患者における潜在的態度と退院後再飲酒との関連. (2014)
  • Author(s): 大谷保和, 合川勇三, 湯本洋介, 梅野充, 榊原聡, 門脇亜理紗, 斎藤環, 森田展彰, 池田和隆
  • Organizer: 日本心理学会第78回大会
  • Place of Presentation: 同志社大学今出川キャンパス（京都府京都市）
  • Year and Date: 2014-09-11
• [Presentation] 鎮痛関連遺伝子多型の情報に基づく術後24時間内フェンタニル投与量の個別化. (2014)
  • Author(s): 吉田香織, 西澤大輔, 高北義彦, 長谷川準子, 笠井慎也, 青木謙典, 一戸達也, 福田謙一, 池田和隆
  • Organizer: 第34回鎮痛薬・オピオイドペプチドシンポジウム(JNRC2014)
  • Place of Presentation: 東京都医学総合研究所（東京都世田谷区）
  • Year and Date: 2014-09-06
• [Presentation] 遺伝子多型判定に基づくオピオイド必要量予測式の応用性の検証. (2014)
  • Author(s): 天野功二郎, 吉田香織, 西澤大輔 福田謙一, 林田眞和, 池田和隆
  • Organizer: 第34回鎮痛薬・オピオイドペプチドシンポジウム(JNRC2014)
  • Place of Presentation: 東京都医学総合研究所（東京都世田谷区）
  • Year and Date: 2014-09-06
• [Presentation] 外科的顎矯正手術におけるUGT2B7遺伝子多型とフェンタニル薬剤感受性の関連について. (2014)
  • Author(s): 村岡渡, 西澤大輔, 長谷川準子, 笠井慎也, 和嶋浩一, 中川種昭, 福田謙一, 池田和隆
  • Organizer: 第34回鎮痛薬・オピオイドペプチドシンポジウム(JNRC2014)
  • Place of Presentation: 東京都医学総合研究所（東京都世田谷区）
  • Year and Date: 2014-09-06
• [Presentation] MRI画像解析による mu オピオイド受容体欠損マウスの大脳灰白質体積の変化. (2014)
  • Author(s): 曽良一郎, 佐々木一益, 住吉晃, 野中博意, 笠原好之, 池田和隆, 渡辺雅彦, 川島隆太
  • Organizer: 第34回鎮痛薬・オピオイドペプチドシンポジウム(JNRC2014)
  • Place of Presentation: 東京都医学総合研究所（東京都世田谷区）
  • Year and Date: 2014-09-06
• [Presentation] Genomic mechanisms underlying individual differences in sensitivity to pain and opioids. (2014)
  • Author(s): 池田和隆
  • Organizer: 第8回都医学研国際シンポジウム－痛みの調節とオピオイド機能－
  • Place of Presentation: 東京都医学総合研究所（東京都世田谷区）
  • Year and Date: 2014-09-05
  • Invited
• [Presentation] ドーパミンシグナルを介した精神疾患病態に関するマイクロエンドフェノタイプの解明. (2014)
  • Author(s): 池田和隆
  • Organizer: 新学術領域「マイクロ精神病態」班会議
  • Place of Presentation: 宮城蔵王ロイヤルホテル（宮城県刈田郡蔵王町）
  • Year and Date: 2014-07-21
• [Presentation] Dopamine-independent motor control and hyperactivity involving acetylcholine systems. (2014)
  • Author(s): Kasai S, Hagino Y, Fujita M, Yanagihara D, Kobayashi K, Ikeda K
  • Organizer: 新学術領域「マイクロ精神病態」班会議
  • Place of Presentation: 宮城蔵王ロイヤルホテル（宮城県刈田郡蔵王町）
  • Year and Date: 2014-07-20
• [Presentation] A view on the new nomenclature from the perspective of the drugs developed in Japan. (2014)
  • Author(s): Yamawaki S, Hashimoto H, Ikeda K, Kato T, Kanba S, Ozaki N, Kusumi I
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-25
• [Presentation] PCLO SNP rs13438494 regulates DA and 5-HT uptake, accompanied with splicing efficiency and dependence-like behaviors in genomic association studies. (2014)
  • Author(s): Uno K, Nishizawa D, Seo S, Sasaki N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Ikeda K, Miyamoto Y, Nitta A
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-24
• [Presentation] Mouse models of tuberous sclerosis complex show autism-related behavioral deficits severer inTsc2 than Tsc1 haploinsufficiency. (2014)
  • Author(s): Sato A, Takamatsu Y, Kasai S, Kobayashi T, Hino O, Ikeda K, Mizuguchi M
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-24
• [Presentation] Reduced supraspinal nociceptive responses and distinct gene expression profile in CXBH recombinant inbred mice. (2014)
  • Author(s): Kasai S, Ikeda K
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-23
• [Presentation] Associations of an orexin (hypocretin) receptor 2 gene polymorphism with nicotine dependence found in genome-wide and following association studies. (2014)
  • Author(s): Nishizawa D, Kasai S, Hasegawa J, Sato N, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Tanaka M, Sugimura H, Ikeda K
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-23
• [Presentation] Applicability of calculation formulas for opioid requirement estimation based on genetic polymorphisms. (2014)
  • Author(s): Amano K, Yoshida K, Nishizawa D, Fukuda K, Hayashida M, Ikeda K
  • Organizer: 2014 YONSEI BK21 PLUS-CBSM International Joint Symposiium
  • Place of Presentation: Andong, Korea
  • Year and Date: 2014-06-21
• [Presentation] Altered reward system in dopamine transporter knock-out mice, a model for attention deficit/hyperactivity disorder. (2014)
  • Author(s): Hua J, Takamatsu Y, Ikeda K
  • Organizer: 2014 YONSEI BK21 PLUS-CBSM International Joint Symposiium
  • Place of Presentation: Andong, Korea
  • Year and Date: 2014-06-21
• [Presentation] Personalized pain control. (2014)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: 2014 YONSEI BK21 PLUS-IGAKUKEN Joint Symposium
  • Place of Presentation: Soul, Korea
  • Year and Date: 2014-06-20
  • Invited
• [Presentation] Applicability of calculation formulas for opioid requirement estimation based on genetic polymorphisms. (2014)
  • Author(s): Amano K, Yoshida K, Nishizawa D, Fukuda K, Hayashida M, Ikeda K
  • Organizer: 2014 YONSEI BK21 PLUS-IGAKUKEN Joint Symposium
  • Place of Presentation: Soul, Korea
  • Year and Date: 2014-06-19 – 2014-06-20
• [Presentation] Altered reward system in dopamine transporter knock-out mice, a model for attention deficit/hyperactivity disorder. (2014)
  • Author(s): Hua J, Takamatsu Y, Ikeda K
  • Organizer: 2014 YONSEI BK21 PLUS-IGAKUKEN Joint Symposium
  • Place of Presentation: Soul, Korea
  • Year and Date: 2014-06-19 – 2014-06-20
• [Presentation] がん性疼痛に対するオピオイド鎮痛薬感受性にはGABA transaminase遺伝子多型が関与する. (2014)
  • Author(s): 住谷昌彦, 西澤大輔, 池田和隆, 山田芳嗣, 厚生労働省TR-Cancer Pain研究班
  • Organizer: 日本麻酔科学会第61回学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-05-15 – 2014-05-17
• [Book] Addiction Medicine (Second Edition)【分担執筆】 (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Total Pages: 672
  • Publisher: OXFORD UNIVERSITY PRESS
• [Book] The Neuropathology of Drug Addictions and Substance Misuse. Volume 1(VR Preedy, Ed) (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Total Pages: 1132
  • Publisher: Academic Press
• [Book] The Neuropathology of Drug Addictions and Substance Misuse. Volume 2 (VR Preedy, Ed) (2016)
  • Author(s): Yamamoto H, Sawada W, Kamegaya E, Hagino Y, Ikeda K, Sora I, Mishina M, Yamamoto T
  • Total Pages: 1143
  • Publisher: Academic Press
• [Book] The Neuropathology of Drug Addictions and Substance Misuse. Volume 1 (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Publisher: Academic Press
• [Book] The Neuropathology of Drug Addictions and Substance Misuse. Volume 2 (2016)
  • Author(s): Yamamoto H, Sawada W, Kamegaya E, Hagino Y, Ikeda K, Sora I, Mishina M, Yamamoto T
  • Publisher: Academic Press
• [Book] Curr Mol Med 【編著】Vol 15, Issue 2 (2015)
  • Author(s): Sawa A, Kida S, Ikeda K (Guest Edited)
  • Publisher: Bentham Science Publishers.
• [Book] Curr Mol Med 【編著】Vol 15, Issue 3 (2015)
  • Author(s): Kida S, Sawa A, Ikeda K (Guest Edited)
  • Publisher: Bentham Science Publishers.
• [Book] 分子脳科学 －分子から脳機能と心に迫る－ (2015)
  • Author(s): 笠井慎也, 池田和隆
  • Total Pages: 312
  • Publisher: (株) 化学同人
• [Book] 痛みのマネジメントupdate－基礎知識から緩和ケアまで－日本医師会雑誌 第143巻・特別号(1) (2014)
  • Author(s): 西澤大輔, 池田和隆
  • Total Pages: 352
  • Publisher: 日本医師会
• [Book] 最新医学別冊 新しい診断と治療のABC 83／精神9 アルコール依存症 (2014)
  • Author(s): 池田和隆
  • Total Pages: 214
  • Publisher: 最新医学社
• [Remarks] 公益財団法人東京都医学総合研究所ホームページ
  • URL: http://www.igakuken.or.jp/
• [Remarks] 依存性薬物プロジェクトホームページ
  • URL: http://www.igakuken.or.jp/abuse/