Elucidation of mechanisms of the prostate cancer progress in consideration of AR Axis / microenvironment and the construction of the innovative treatment strategy
| Project/Area Number |
26293350
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAMIKI Mikio 金沢大学, 医学系, 教授 (70155985)
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| Co-Investigator(Kenkyū-buntansha) |
溝上 敦 金沢大学, 医学系, 准教授 (50248580)
泉 浩二 金沢大学, 医学系, 特任助教 (80646787)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | SOD3 / 前立腺癌 / 共培養 / 間質細胞 / クロストーク / 微小環境 / フラボノイド誘導体 / ｱﾝﾄﾞﾛｹﾞﾝ / ｱﾝﾄﾞﾛｹﾞﾝ受容体 / アンドロゲン感受性前立腺癌細胞 / アンドロゲン非依存性前立腺癌細胞 / アンドロゲン生合成 |
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| Outline of Final Research Achievements |
We identified identified superoxide disumutase 3 (SOD3) which expression was decreased in prostate caner tissue compared with normal tissue. SOD3 was related with metabolism of the active oxygen and worked as a tumor inhibiting factor.
When prostate cancer cells were cocultured with derived derived from and prostate cancer and added a large quantity of testosterone into coculture, the proliferation of the prostate cancer cells was inhibited. This mechanism was involved in estrogen synthesis in stroll cells.
Furthermore, when androgen-sensitive prostate cancer cells were cocultured with andorgen-insensitive prostate cancer cells, the proliferation of androgen-sensitive prostate cancer cells in the presence of androgen was accelerated by androgen-insensitive cells. Moreover, invasion of androgen-insensitive cells was induced by androgen-sensitive cells. We synthesized flavored derivatives and confirmed anti-caner effect.
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Report
(4 results)
Research Products
(5 results)
