| Project/Area Number |
26293355
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Fujita Health University |
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Principal Investigator |
Kusaka Mamoru 藤田保健衛生大学, 医学部, 教授 (40309141)
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| Co-Investigator(Kenkyū-buntansha) |
山田 和彦 鹿児島大学, 学内共同利用施設等, 教授 (40241103)
佐原 寿史 鹿児島大学, 学内共同利用施設等, 准教授 (90452333)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSHINAGA Kiyotaka 藤田保健衛生大学, 医学部, 教授 (30229174)
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| Research Collaborator |
MIURA Kouhei
KAWAI Akihiro
WAKI Shiori
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 移植・再生医療 / 腎移植 / 常温腎臓持続体外灌流保存 / マージナルドナー / 臓器保護 / 前臨床実験 / ミニブタ / 虚血再潅流障害 / 移植 再生医療 / 一酸化炭素 / HMGB1 / 虚血再灌流障害 |
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| Outline of Final Research Achievements |
In this study, we focused on agents with various cytoprotective effects on marginal donor kidneys where activation of inflammatory precursors caused tissue injury. Using established MHC miniture swine which can evaluate detailed immune reaction, we investigated the effect of organ protection and repair by drug administration to donor, recipient, graft persistent perfusion preservation. We conducted experiments to establish a strategy to restore and recover marginal donor organs to conditions comparable to living organs.
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