| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
It is suggested that the early embryo culture accompanying artificial reproductive technologies (ART) may cause iatrogenic epimutations and could cause genomic imprinting disorders. However, molecular epidemiological studies do not show a clear relationship between the two. Therefore, we analyzed the DNA methylation in the whole genome, focusing on areas other than genomic imprinting. The epigenetic analysis result by "genetic factors (SNP etc.)" were removed and epigenetic data were effectively normalized. Then, we performed various statistical analyzes. So far, no obtained analysis results suggest possible relation between the infants by ART and the infants outcome of spontaneous pregnancy.
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