Verification of possible iatrogenic epimutations by artificial reproductive technologies.
| Project/Area Number |
26293365
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
HATA KENICHIRO 国立研究開発法人国立成育医療研究センター, 周産期病態研究部, 部長 (60360335)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | エピゲノム / DNAメチル化 / 生殖補助医療 / エピジェネティクス / ゲノムインプリンティング |
|---|
| Outline of Final Research Achievements |
It is suggested that the early embryo culture accompanying artificial reproductive technologies (ART) may cause iatrogenic epimutations and could cause genomic imprinting disorders. However, molecular epidemiological studies do not show a clear relationship between the two. Therefore, we analyzed the DNA methylation in the whole genome, focusing on areas other than genomic imprinting. The epigenetic analysis result by "genetic factors (SNP etc.)" were removed and epigenetic data were effectively normalized. Then, we performed various statistical analyzes. So far, no obtained analysis results suggest possible relation between the infants by ART and the infants outcome of spontaneous pregnancy.
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Report
(5 results)
Research Products
(13 results)
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[Journal Article] The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes.2018
Author(s)
Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G, Hata K, Nohara K
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Journal Title
BMC Cancer
Volume: 18
Issue: 1
Pages: 317-317
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] CTCF deletion syndrome: Clinical features and epigenetic delineation2017
Author(s)
Hori I, Kawamura R, Nakabayashi K, Watanabe H, Higashimoto K, Tomikawa J, Ieda D, Ohashi K, Negishi Y, Hattori A, Sugio Y, Wakui K, Hata K, Soejima H, Kurosawa K, Saitoh S
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Journal Title
Journal of Medical Genetics
Volume: 54
Issue: 12
Pages: 836-842
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Compilation of copy number variants identified in phenotypically normal and parous Japanese women.2014
Author(s)
Migita O, Maehara K, Kamura H, Miyakoshi K, Tanaka M, Morokuma S, Fukushima K, Shimamoto T, Saito S, Sago H, Nishihama K, Abe K, Nakabayashi K, Umezawa A, Okamura K, Hata K
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Journal Title
Journal of Human Genetics
Volume: 59
Pages: 326-331
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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