The regulation of bioactive molecule dynamics and development of real-time imaging technics for glaucoma therapy.
| Project/Area Number |
26293375
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
井上 俊洋 熊本大学, 医学部附属病院, 講師 (00317025)
岩尾 圭一郎 熊本大学, 医学部附属病院, 助教 (30549118)
高橋 枝里 熊本大学, 大学院生命科学研究部, 助教 (60622602)
川路 隆博 熊本大学, 医学部附属病院, 講師 (30423677)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 緑内障 / サイトカイン / 生理活性 / シグナル伝達 / 生体分子 |
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| Outline of Final Research Achievements |
The concentration of inflammatory cytokines, such as IL-6 and MCP-1, were elevated in aqueous humor of uveitic glaucoma and neovascularization glaucoma in comparison with primary open angle glaucoma. Further, prospective study using 3-dimentional anterior-segment OCT indicated the width of filtration openings on the edge of the scleral flap as an aqueous route decreased time-dependently, and that the width was correlated with the concentration of MCP-1 in aqueous humor. Moreover, cell based assay using conjunctival fibroblasts indicated that HDAC inhibitor suppressed trans-differentiation of fibroblasts into myofibroblasts. These results provide novel targets for glaucoma therapy.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Comparing trabeculectomy outcomes between first and second operated eyes: A multicenter study.2016
Author(s)
Iwasaki K, Takamura Y, Nishida T, Sawada A, Iwao K, Shinmura A, Kunimatsu-Sanuki S, Yamamoto T, Tanihara H, Sugiyama K, Nakazawa T, Inatani M.
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Journal Title
PLOS ONE
Volume: 11
Issue: 9
Pages: e0162569-e0162569
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: a randomized, open-label, crossover study.2014
Author(s)
Tanihara H, Inoue T, Yamamoto T, Kuwayama Y, Abe H, Suganami H, Araie M; the K-115 Clinical Study Group.
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Journal Title
Acta Ophthalmologica
Volume: 93
Issue: 4
Pages: 254-260
DOI
Related Report
Peer Reviewed
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[Presentation] Histone deacetylase inhibitor attenuates TGF-β2 induced human conjunctival fibroblast activation.2015
Author(s)
Futakuchi A, Inoue T, Fujimoto T, Kuroda U, Inoue-Mochita M, Takahashi E, Shobayashi K, Ohira S, Kojima S, Tanihara H.
Organizer
The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
Place of Presentation
Denver, Colorado, USA
Year and Date
2015-05-03
Related Report
Int'l Joint Research
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