| Project/Area Number |
26293375
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
井上 俊洋 熊本大学, 医学部附属病院, 講師 (00317025)
岩尾 圭一郎 熊本大学, 医学部附属病院, 助教 (30549118)
高橋 枝里 熊本大学, 大学院生命科学研究部, 助教 (60622602)
川路 隆博 熊本大学, 医学部附属病院, 講師 (30423677)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 緑内障 / サイトカイン / 生理活性 / シグナル伝達 / 生体分子 |
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| Outline of Final Research Achievements |
The concentration of inflammatory cytokines, such as IL-6 and MCP-1, were elevated in aqueous humor of uveitic glaucoma and neovascularization glaucoma in comparison with primary open angle glaucoma. Further, prospective study using 3-dimentional anterior-segment OCT indicated the width of filtration openings on the edge of the scleral flap as an aqueous route decreased time-dependently, and that the width was correlated with the concentration of MCP-1 in aqueous humor. Moreover, cell based assay using conjunctival fibroblasts indicated that HDAC inhibitor suppressed trans-differentiation of fibroblasts into myofibroblasts. These results provide novel targets for glaucoma therapy.
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