| Project/Area Number |
26293379
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
MURAO Naoki 北海道大学, 大学病院, 助教 (90706558)
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| Co-Investigator(Kenkyū-buntansha) |
舟山 恵美 北海道大学, 医学(系)研究科(研究院), 講師 (10533630)
山本 有平 北海道大学, 医学(系)研究科(研究院), 教授 (70271674)
小山 明彦 北海道大学, 大学病院, 講師 (70374486)
七戸 龍司 北海道大学, 大学病院, 医員 (30640346)
古川 洋志 北海道大学, 医学(系)研究科(研究院), 准教授 (00399924)
林 利彦 北海道大学, 歯学研究科(研究院), 准教授 (00432146)
齋藤 典子 北海道大学, 医学(系)研究科(研究院), 客員研究員 (80374487)
関堂 充 筑波大学, 医学医療系, 教授 (40372255)
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| Co-Investigator(Renkei-kenkyūsha) |
SEINO Kenichiro 北海道大学, 遺伝子病制御研究所, 教授 (20312845)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | ケロイド / 免疫 / 制御性T細胞 |
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| Outline of Final Research Achievements |
Keloid is an inflammatory and fibrotic disease. CD4+ T cells have been shown to play an important role in regulating inflammation and fibrosis. CD4+ T cells, especially regulatory T cells, suppress the inflammatory response and the expression of inflammatory cytokines via secreting an anti inflammatory cytokine IL-10. Nevertheless, little is known about the role of CD4+ T cells in the pathogenesis of keloid. We therefore investigated the interaction between CD4+ T cells and keloid fibroblasts using a coculture system. Our data suggested that IL-10 secreted from CD4+ T cells attenuate IL-6 production in keloid fibroblasts. Strategies to activate CD4+ T cells secreting IL-10 in keloids might represent a novel approach for the treatment of keloids.
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