Development of vascular maturation and vascularization into the regenerative tissue via co-administration of stem cells and control-released growth factors
| Project/Area Number |
26293382
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
林 礼人 順天堂大学, 医学部, 教授 (10365645)
飛田 護邦 順天堂大学, 革新的医療技術開発研究センター, 准教授 (10599038)
田中 里佳 順天堂大学, 医学部, 先任准教授 (70509827)
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| Research Collaborator |
SHINGYOCHI Yoshiaki 順天堂大学, 医学部, 助教
KADO Makiko 順天堂大学, 医学部, 非常勤助教
HASEGAWA Yu 順天堂大学, 医学部, 非常勤助手
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Keywords | 血管再生 / 再生医療 / 幹細胞 / 増殖因子 / 再生医学 |
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| Outline of Final Research Achievements |
Sufficient blood supply into any regenerative tissues and organs is mandatory for their long-time survival. In this study, we sought to determine if (1) co-administration of both stem cells and growth factors may facilitate inducing blood vessel maturation as well as increasing blood supply or vascular density and (2) co-administration of both stem cells and growth factors into the fascia flap which wrapped the beta tricalcium phosphate cube could also augment blood supply in order to regenerate bony tissue. The results showed that (1) maturation of the blood vessel was successfully induced by co-administration of both adipose derived stem cells and control-released basic fibroblast growth factor in both murine ischemic hindlimb model and wound healing model in diabetic mice, and (2) vessel maturation was also confirmed in prefabricated fascial model. However, we have not yet found any significant angiogenesis into the beta tricalcium phosphate.
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Report
(5 results)
Research Products
(17 results)
