| Project/Area Number |
26293385
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
MARUYAMA Ikuro 鹿児島大学, 医歯学総合研究科, 特任教授 (20082282)
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 隆史 鹿児島大学, 医歯学総合研究科, 講師 (20381171)
川原 幸一 大阪工業大学, 工学部, 教授 (10381170)
山口 宗一 鹿児島大学, 医歯学域医学系, 准教授 (20325814)
橋口 照人 鹿児島大学, 医歯学域医学系, 教授 (70250917)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Mika 鹿児島大学, 医歯学総合研究科, 特任研究員 (70791507)
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| Research Collaborator |
NAGASATO Tomoka 藤森工業株式会社
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | Alarmin / PAMPs / DAMPs / HMGB1 / Histones / DIC / Shock / 多臓器不全 / RAMPs / histones / thrombomodulin / protein C / NETs / ヒストン / レドックス状態 / ヒト化モノクローナル抗体 / 敗血症性ショック / トロンボモジュリン / HMGB1酸化還元型 / エピジェネティック |
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| Outline of Final Research Achievements |
Upon injuries and invasions, locally generated damage associated molecular patterns(DAMPs) and invaded molecules of pathogens, pathogen associated molecular patterns(PAMPs) are integrated as alarmins, and recognized by toll-like receptors(TLRs)-expressing cells including epithelial cells and immune cells, and result the formation of total defensive system in situ. These DAMPs and PAMPs, however, should be localized in the local injurious sites and be limited active temporarily.
This spatio-temporal axis of DAMPs/PAMPs-TLRs is very important for the expression of most optimum defense system and following resolution and wound repair. The excess and deviations of reactions induced by DAMPs/PAMPs cause shock, DIC and multi-organ failures. Based on these data, we propose a rationale of therapeutic principles for injuries, infections and malignancies for prevention of systemic involvements including DIC, shock and multi-organ failures.
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