Multimode analyses of skeletogenesis by imaging, simulation and omics
| Project/Area Number |
26293392
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
李 智媛 愛媛大学, プロテオサイエンスセンター, 助教(特定教員) (70711274)
疋田 温彦 東京大学, 医学部附属病院, 特任准教授 (60443397)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 骨代謝 / 骨粗鬆症 / 破骨細胞 / HIV / シグナル / 骨格 / 骨芽細胞 / ケモカイン / 骨 / 軟骨 / 形態形成 / 骨格形成 / 骨吸収性疾患 / イメージング / シミュレーション / 老化 / 恒常性 / 発生 |
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| Outline of Final Research Achievements |
The purpose of this research grant was to identify important genes during skeletal development, and further validate the role of candidate genes by analysis of knock-out mice. We identified some cc-chemokines expressing in developing skeletal tissues. One of prominent advance in this research was that a chemokine receptor CCR5, also a HIV co-receptor, was essential for osteoporosis. Clinical reports suggested that HIV treatment targeting CCR5 may cause less-susceptibility to bone-destructive diseases such as rheumatoid arthritis and osteoporosis. We uncovered that anti-CCR5 neutralization antibody as well as a CCR5 inhibitory drug, Maraviroc, blocked osteoclast differentiation and function through damaging their actin-ring formation. Moreover, CCR5-deficient mice were resistant to osteoporotic stimuli. These findings experimentally supports the clinical reports as mentioned above, and suggest that HIV therapy targeting CCR5 may provide skeletal merits.
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Report
(5 results)
Research Products
(76 results)
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[Journal Article] The HIV co-receptor CCR5 regulates osteoclast function.2017
Author(s)
Lee JW, Hoshino A, Inoue K, Saitou T, Uehara S, Kobayashi Y, Ueha S, Matsushima K, Yamaguchi A, Imai Y, Iimura T.
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Journal Title
Nat Commun
Volume: 8
Issue: 1
Pages: 2226-2226
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Bone Research2017
Author(s)
Aya Tanaka, Ji-Won Lee, Kyoko Hirano, Yukihiro Isogai, Toshinori Ishizuya, Rhoko Takao-Kawabata, Tadahiro Iimura
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Journal Title
Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariwctomized rats
Volume: 5
Issue: 1
Pages: 17002-17002
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Journal of Oral Biosciences2017
Author(s)
Tadahiro Iimura, Ji-Won Lee
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Journal Title
Unveiling a rhythmic regulatory mode hidden in developmental tissue growth by fluorescence live imaging-based mathematical modeling
Volume: 59
Issue: 1
Pages: 6-11
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] In vivo subcellular imaging of tumors in mouse models using a fluorophore-conjugated anti-CEA antibody in TPEM2014
Author(s)
Shigehiro Koga, Yusuke Oshima, Naoki Honkura, Tadahiro Iimura, Kenji Kameda, Koichi Sato, Motohira Yoshida, Yuji Yamamoto, Yuji Watanabe, Atsuhiko Hikita, and Takeshi Imamura
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Journal Title
Cancer Science
Volume: 105(10)
Issue: 10
Pages: 1299-1306
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal is required for geometric architecture and function of osteoclasts, thus for RANKL-induced bone destruction2016
Author(s)
Lee JW, Hoshino A, Saitou T, Inoue K, Uehara, S, Kobayashi Y, Matsushima K, Imai Y, Iimura T.
Organizer
43rd Annual European Calcified Tissue Society Congress
Place of Presentation
Rome, Italy
Year and Date
2016-05-14
Related Report
Int'l Joint Research
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