| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
Breast, prostate and lung cancer frequently metastasized to bone, leading to poor outcome of these cancer patients. Bone provides a fertile microenvironment, designated as bone metastatic niche, for cancer cells arrested in bone and modulate aggressiveness of these cancer cells. In the current study, we showed that a transcription factor that is up-regulated in breast cancer cells under the influences of bone metastatic niche promotes bone metastasis via increasing bone destruction.
Majority of cancer patients with bone metastases demonstrate intractable bone pain at advanced or terminal stages. We found that osteocytes, which are one of the components of bone metastatic niche, modulate bone pain via establishing the interactions with sensory nerves innervating bone. Further, we also showed that an acidic microenvironment created by cancer cells plays a critical role in the induction of bone pain. These results will lead to better management and improved QOL in cancer patients.
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