Biological crosstalk between cancer and bone during bone metastasis
| Project/Area Number |
26293394
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Yoneda Toshiyuki 大阪大学, 歯学研究科(研究院), 招へい教員 (80142313)
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| Co-Investigator(Renkei-kenkyūsha) |
HATA Kenji 大阪大学, 大学院歯学研究科, 准教授 (80444496)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | 骨転移 / 骨痛 / 微小環境 / 骨細胞 |
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| Outline of Final Research Achievements |
Breast, prostate and lung cancer frequently metastasized to bone, leading to poor outcome of these cancer patients. Bone provides a fertile microenvironment, designated as bone metastatic niche, for cancer cells arrested in bone and modulate aggressiveness of these cancer cells. In the current study, we showed that a transcription factor that is up-regulated in breast cancer cells under the influences of bone metastatic niche promotes bone metastasis via increasing bone destruction.
Majority of cancer patients with bone metastases demonstrate intractable bone pain at advanced or terminal stages. We found that osteocytes, which are one of the components of bone metastatic niche, modulate bone pain via establishing the interactions with sensory nerves innervating bone. Further, we also showed that an acidic microenvironment created by cancer cells plays a critical role in the induction of bone pain. These results will lead to better management and improved QOL in cancer patients.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma2015
Author(s)
1.Hiasa M, Teramachi J, Oda A, Amachi R, Harada T, Nakamura S, Miki H, Fujii S, Kagawa K, Watanabe K, Endo I, Kuroda Y, Yoneda T, Tsuji D, Nakao M, Tanaka E, Hamada K, Sano S, Itoh K, Matsumoto T, Abe M.
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Journal Title
Leukemia
Volume: 29
Pages: 207-217
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Osteocytes are an Important Mediator of Bone Pain in Myeloma2015
Author(s)
Hiasa M, Okui T Nagata Y, Allette YM, Ripsch MS, Delgado-Calle J, Bellido T, Roodman DG, Plotkin R, White F, Yoneda T
Organizer
ASBMR annual meeting
Place of Presentation
Seattle, USA
Year and Date
2015-10-09
Related Report
Int'l Joint Research
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[Presentation] Osteocytes directly communicate with sensory neuronal cells in bone via cell-cell networks that are modulated under an acidic microenvironment.2014
Author(s)
Hiasa M, Nagata Y, Delgado-Calle J, Allette Y, Ripsch MS, Bellido T, Roodman GD, White FA, Yoneda T.
Organizer
36th Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Houston, TX, USA
Year and Date
2014-09-12 – 2014-09-15
Related Report
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