Mechanisms underlying formation of tissue domains integrating the skeletal components
| Project/Area Number |
26293395
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Shukunami Chisa 広島大学, 医歯薬保健学研究院, 教授 (60303905)
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| Co-Investigator(Kenkyū-buntansha) |
滝本 晶 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (00378902)
秋山 治彦 岐阜大学, 医学(系)研究科(研究院), 教授 (60402830)
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| Research Collaborator |
GERD SCHERER Freiburg University
RALF KIST Newcastle University
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 発生・分化 / 腱 / 靭帯 / 硬組織 / 遺伝子改変動物 / ゲノム編集 / 靱帯 / 顎関節 / 発生･分化 |
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| Outline of Final Research Achievements |
In this study, we generated and analyzed genetically modified mice to analyze the mechanisms underlying tendon/ligament and enthesis formation. We analyzed mice lacking Scleraxis (Scx), a basic helix-loop-helix transcription factor, to find that Scx is required for maturation of tissue domains for proper integration of the musculoskeletal system. Analysis of conditional knockout mice lacking Sox9 in the Scx-expressing region, we found that Sox9 is important for formation of the tenpolomandibular joint during development. Lineage analysis and double immunostaining revealed that cells expressing both Scx and Sox9 contribute to formation of the enthesis.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Tenomodulin is required for tendon endurance runnning and collagen I fibril adaptation to mechanical load.2017
Author(s)
Dex S, Alberton P, Willkomm L, Soellradl T, Milz S, Shakivaei M, Ignatius A, Bloch W, Clausen-Schaumann H, Shukunami C, Schieker M, Docheva D.
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Journal Title
EbioMedicine
Volume: -
Pages: 240-254
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation.2016
Author(s)
Guo, L., Yamashita, H., Kou, I., Takimoto, A., Meguro-Horike, M., Horike, S., Adachi, T., Ikegawa, S., Hiraki, Y., Shukunami, C.
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Journal Title
Plos Genetics
Volume: 12
Issue: 1
Pages: e1005802-e1005802
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 腱・靱帯形成の分子メカニズム2016
Author(s)
宿南 知佐
Organizer
第37回北海道大学獣医学学術交流基金群講演会
Place of Presentation
札幌市、北海道大学大学院獣医学研究科講堂
Year and Date
2016-01-21
Related Report
Invited
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[Presentation] 腱・靱帯付着部の形成機構2015
Author(s)
宿南 知佐
Organizer
第28回日本軟骨代謝学会
Place of Presentation
東京都文京区 東京医科歯科大学 鈴木章夫記念講堂
Year and Date
2015-03-07
Related Report
Invited
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