| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
In this study, we investigated to identify the "activation" molecule of osteoclast associated with c-Src-p130Cas axis and further clarify its function in vitro. A comprehensive analysis was performed using osteoclasts derived from c-Src- or p130Cas-eficient mice. We have identified some candidate proteins as "activation" molecule of osteoclast. Among them, we focused two molecules, protein phosphatase 1 regulatory subunit 18 (PPP1r18) and Bif-1. PPP1r18 serves as a negative regulator of c-Src-p130Cas axis-dependent bone resorption. Bif-1 modulates osteoclastic bone resorption by regulating c-Src-p130Cas axis-dependent osteoclastic survival.
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