Identification of bone resorbing molecules downstream of c-Src-p130Cas axis
| Project/Area Number |
26293396
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Eijiro Jimi 九州歯科大学, 歯学部, 教授 (40276598)
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| Co-Investigator(Kenkyū-buntansha) |
福島 秀文 東北大学, 歯学研究科(研究院), 准教授 (70412624)
片桐 岳信 埼玉医科大学, 医学部, 教授 (80245802)
杉山 悟郎 九州歯科大学, 歯学部, 助教 (00722828)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | p130Cas / c-src / 破骨細胞 / 骨吸収 / c-Src |
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| Outline of Final Research Achievements |
In this study, we investigated to identify the "activation" molecule of osteoclast associated with c-Src-p130Cas axis and further clarify its function in vitro. A comprehensive analysis was performed using osteoclasts derived from c-Src- or p130Cas-eficient mice. We have identified some candidate proteins as "activation" molecule of osteoclast. Among them, we focused two molecules, protein phosphatase 1 regulatory subunit 18 (PPP1r18) and Bif-1. PPP1r18 serves as a negative regulator of c-Src-p130Cas axis-dependent bone resorption. Bif-1 modulates osteoclastic bone resorption by regulating c-Src-p130Cas axis-dependent osteoclastic survival.
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Report
(4 results)
Research Products
(9 results)
