Analysis of neuronal mechanisms controlling swallowing using arterially perfused decerebrate rats
| Project/Area Number |
26293397
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
INOUE TOMIO 昭和大学, 歯学部, 教授 (70184760)
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| Co-Investigator(Kenkyū-buntansha) |
中山 希世美 昭和大学, 歯学部, 講師 (00433798)
望月 文子 昭和大学, 歯学部, 助教 (10453648)
鬼丸 洋 昭和大学, 医学部, 客員教授 (30177258)
中村 史朗 昭和大学, 歯学部, 准教授 (60384187)
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| Research Collaborator |
TACHIKAWA Satoshi
NAGATA Shoko
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 嚥下 / 除脳動物動脈灌流標本 / 呼吸 / 反回神経 / 舌下神経 / 迷走神経 / イミダプリル塩酸塩 / シロスタゾール / ロズマリン酸 / 除脳灌流標本 / Substance P / 孤束核 / 動脈灌流標本 / パターン形成機構 / 舌骨下筋群 / 高二酸化炭素血症 / セロトニン / 閉口筋運動ニューロン / NMDA受容体 |
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| Outline of Final Research Achievements |
Pharmacological agents that elevate dopamine and substance P concentrations have been suggested to improve impaired swallowing processes. We examined the effects of imidapril hydrochloride and cilostazol, often prescribed for swallowing disorders, on swallowing motor activity, using arterially perfused decerebrate rats aged from postnatal day 21-33. Efferent nerve activities from the vagal nerve (VN), hypoglossal nerve, and phrenic nerve were recorded. Injection of distilled water into the oral cavity consistently inhibited inspiratory activities, and evoked synchronized swallowing burst discharges by the VN. After administration of imidapril or cilostazol to the perfusate, the mean peak amplitudes of swallowing discharges of VN in both administration groups were significantly greater than the non-administration group. These results suggest that both imidapril and cilostazol administrations improve impaired swallowing increasing pharyngeal muscle activities.
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Report
(5 results)
Research Products
(87 results)
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[Journal Article] Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus2017
Author(s)
Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Satoh F, Kawakami H, Takahashi K, Inoue T.
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Journal Title
Neuroscience
Volume: 358
Pages: 211-226
DOI
Related Report
Peer Reviewed
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[Journal Article] Down-regulation of Irf8 by Lyz2-cre/loxP accelerates osteoclast differentiation in vitro2017
Author(s)
Saito E, Suzuki D, Kurotaki D, Mochizuki A, Manome Y, Suzawa T, Toyoshima Y, Ichikawa T, Funatsu T, Inoue T, Takami M, Tamura T, Inagaki K, and Kamijo R
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Journal Title
Cytotechnology
Volume: 印刷中
Issue: 3
Pages: 443-450
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice2016
Author(s)
Ikawa Y, Mochizuki A, Katayama K, Kato T, Ikeda M, Abe Y, Nakamura S, Nakayama K, Wakabayashi N, Baba K, Inoue T
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Journal Title
Neurosci Res
Volume: 113
Pages: 48-55
DOI
Related Report
Peer Reviewed
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[Presentation] Distinctive properties of Phox2b neurons located in the rat reticular formation dorsal to the trigeminal motor nucleus2017
Author(s)
Nagoya K, Nakamura S, Ikeda K, Onimaru H, Nakayama K, Mochizuki A, Sato F, Yoshida A, Kawakami K, Inoue M, Inoue T.
Organizer
Society for Neuroscience 47th annual meeting
Related Report
Int'l Joint Research
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[Presentation] The effects of citalopram on masseter and neck muscle activities in mice2015
Author(s)
Nogawa Y, Mochizuki A, Katayama K, Ikeda M, Abe Y, Nakamura S, Nakayama K, Kiyomoto M, Kato T, Baba K, Wakabayashi N, Inoue T
Organizer
Society for Neuroscience 45th annual meeting
Place of Presentation
Chicago
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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[Presentation] Modulation of masseter activity by vigilance states and circadian rhythm2015
Author(s)
Mochizuki A, Katayama K, Kato T, Ikeda M, Nogawa Y, Nakamura S, Nakayama K, Kiyomoto M, Wakabayashi N, Baba K, Inoue T
Organizer
第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
Place of Presentation
神戸
Year and Date
2015-03-23
Related Report
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[Presentation] Histaminergic modulation of oral-motor activity2014
Author(s)
Kiyomi Nakayama, Chikako Gemba, Shiro Nakamura, Ayako Mochizuki, Mitsuko Inoue, Tomio Inoue
Organizer
NANOSYMPOSIUM; 583.Brainstem: Motor and Sensory Systems, 583.09, Neuroscience 2014
Place of Presentation
Washington DC
Year and Date
2014-11-15 – 2014-11-19
Related Report
Invited
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