Development of brachytherapy for early stage oral cancer using I-125 seeds
| Project/Area Number |
26293399
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Miura Masahiko 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10272600)
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| Co-Investigator(Kenkyū-buntansha) |
林 良雄 東京薬科大学, 薬学部, 教授 (10322562)
吉村 亮一 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (40302864)
戒田 篤志 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (40632097)
岡本 裕之 国立研究開発法人国立がん研究センター, その他部局等, その他 (90595729)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 小線源治療 / 口腔癌 |
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| Outline of Final Research Achievements |
Low dose-rate brachtytherapy is a definitive radiotherapy for early stage oral cancer. Au-198 grains are often used for the therapy; however, their supply has been insufficient since The Great East Japan Earthquake. The objective of this study was to examine whether Au-198 grains could be replaced by I-125 seeds usually used for the prostate cancer treatment. For this purpose, three dimensional absorption dose distribution was simulated and temporo-spatial kinetics of G2 arrest was analyzed. When applied to mold therapy using transient treatment instead of eternal implant, we tentatively propose that Au-198 grains could be replaced by I-125 seeds when ten times more number of I-125 seeds are used compared with that of Au-198 grains.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.2014
Author(s)
Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K, Yakushiji F, Miura M, Usui T, Hayashi Y.
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Journal Title
ACS Med Chem Lett.
Volume: 5
Issue: 10
Pages: 1094-1098
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Oral Cancer and brachytherapy2017
Author(s)
Masahiko Miura
Organizer
The 39th Annual Scientific Conference on Dental Research
Place of Presentation
University of Medicine and Pharmacy at Ho Chi Minh City（Ho chi Minj City, Vietnam）
Year and Date
2017-04-02
Related Report
Int'l Joint Research / Invited
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