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A study of materials property and osteoconductive capacity of bone substitutes

Research Project

Project/Area Number 26293417
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

Suzuki Osamu  東北大学, 歯学研究科(研究院), 教授 (60374948)

Co-Investigator(Kenkyū-buntansha) 穴田 貴久  東北大学, 歯学研究科(研究院), 准教授 (30398466)
増本 博  東北大学, 学内共同利用施設等, 教授 (50209459)
川井 忠  東北大学, 大学病院, 助教 (50547263)
井樋 栄二  東北大学, 医学(系)研究科(研究院), 教授 (80193465)
Co-Investigator(Renkei-kenkyūsha) ARAI FUMIHITO  名古屋大学, 大学院工学研究科, 教授 (90221051)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords生体材料 / 組織工学 / 骨再生 / 生体材料学 / 結晶 / バイオセラミックス / リン酸カルシウム
Outline of Final Research Achievements

The present study was designed to investigate as to whether calcium phosphate in matrix polymer materials affects oriented bone formation. Octacalcium phosphate without the matrix stimulated macrophage-like cells migration. The presence of gelatin controls the crystallite size and the hydrolysis rate. Octacalcium phosphate in gelatin matrix affects the production of oriented bone formation in rat calvaria defect. The composite stimulated the formation of cortical bone having strength compatible to natural bone in rabbit tibia defect (push-in-test). The presence of octacalcium phosphate in the matrix material could be associated with the quality of newly formed bone.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (33 results)

All 2016 2015 2014 Other

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 5 results,  Open Access: 2 results) Presentation (21 results) (of which Int'l Joint Research: 7 results,  Invited: 6 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Effect of resorption rate and osteoconductivity of biodegradable calcium phosphate materials on the acquisition of natural bone strength in the repaired bone2016

    • Author(s)
      S Chiba, T Anada, K Suzuki, K Saito, Y Shiwaku, N Miyatake, Baba, H Imaizumi, M Hosaka, E Itoi, O Suzuki
    • Journal Title

      J Biomed Mater Res A

      Volume: 104 Issue: 11 Pages: 2833-2842

    • DOI

      10.1002/jbm.a.35828

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Immune cell response and subsequent bone formation induced by implantation of octacalcium phosphate in a rat tibia defect2016

    • Author(s)
      B Hirayama, T Anada, Y Shiwaku, N Miyatake, K Tsuchiya, M Nakamura, T Takahashi, O Suzuki
    • Journal Title

      RSC Adv

      Volume: 6 Issue: 62 Pages: 57475-57484

    • DOI

      10.1039/c6ra10834b

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oriented bone regenerative capacity of octacalcium phosphate/gelatin composites obtained through two-step crystal preparation method2016

    • Author(s)
      Ishiko-Uzuka R, Anada T, Kobayashi K, Kawai T, Tanuma Y, Sasaki K, Suzuki O
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: in press Issue: 5 Pages: 1029-1039

    • DOI

      10.1002/jbm.b.33640

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orthodontic osteogenecity enhanced by a porous gelatin sponge in a critical-sized rat calvaria defect2015

    • Author(s)
      Kanda N, Anada T, Handa T, Kobayashi K, Ezoe Y, Takahashi T, Suzuki O
    • Journal Title

      Macromol Biosci.

      Volume: 15 Issue: 12 Pages: 1647-1655

    • DOI

      10.1002/mabi.201500191

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of partially hydrolyzed OCP crystals deposited in a gelatin matrix as a scaffold for bone tissue engineering.2015

    • Author(s)
      Ezoe Y, Anada T, Yamazaki H, Handa T, Kobayashi K, Takahashi T, Suzuki O
    • Journal Title

      J Nanopart Res

      Volume: 17 Issue: 3 Pages: 140-140

    • DOI

      10.1007/s11051-015-2864-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chondroitin sulfate-E binds to both osteoactivin and integrin αVβ3 and inhibits osteoclast differentiation2014

    • Author(s)
      T Miyazaki, S Miyauchi, T Anada1, A Tawada, O Suzuki
    • Journal Title

      J Cell Biochem

      Volume: in press Issue: 10 Pages: 2247-2257

    • DOI

      10.1002/jcb.25175

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] First clinical application of octacalcium phosphate collagen composite in human bone defect2014

    • Author(s)
      T Kawai, S Echigo, K Matsui, Y Tanuma, T Takahashi, O Suzuki, S Kamakura
    • Journal Title

      Tissue Eng Part A

      Volume: 20 Pages: 1336-1341

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] リン酸オクタカルシウムの初期炎症反応と骨再生への効果2016

    • Author(s)
      塩飽由香利、平山聞一、穴田貴久、宮武尚央、土屋香織、中村雅典、高橋哲、鈴木治
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of dissolution behaviour of octacalcium phosphate and β-tricalcium phosphate bone substitute materials2016

    • Author(s)
      Suzuki O , Sakai S , Anada T , Tsuchiya K , Yamazaki H , Margolis HC
    • Organizer
      International Dental Material Congress 2016
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relation between Biodegradability and Osteoconductivity in Octacalcium Phosphate-based Bone Substitute Material2016

    • Author(s)
      O. Suzuki, T. Anada, S. Chiba, R. Ishiko-Uzuka, Y. Shiwaku, K. Sasaki, E. Itoi
    • Organizer
      28th Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics 28)
    • Place of Presentation
      Charlotte、USA
    • Year and Date
      2016-10-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crystal maturation process of calcium phosphate in the preparation of bone substitute material and bone regeneration capacity2016

    • Author(s)
      O Suzuki, T Anada, Y Shiwaku
    • Organizer
      E-MRS 2016 Fall Meeting and Exhibition
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2016-09-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of gelatin molecules on the structural characteristics during precipitation and hydrolysis of octacalcium phosphate and the bioactivity of the composite2016

    • Author(s)
      O Suzuki, T Anada, K Tsuchiya, R Ishiko-Uzuka, K Sasaki
    • Organizer
      10th World Biomaterials Congress (WBC 2016)
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2016-05-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リン酸オクタカルシウムによる早期骨再生のメカニズムの解明2016

    • Author(s)
      平山聞一 , 穴田貴久 , 塩飽由香利 , 宮武尚央,土屋香織, 中村雅典 , 高橋 哲 , 鈴木 治
    • Organizer
      第 67 回日本歯科理工学会学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] バイオマテリアル表面と石灰化組織の再生2016

    • Author(s)
      鈴木治
    • Organizer
      第70回精研シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Efficacy of calcium phosphate-based scaffold materials on mineralized and non-mineralized tissue regeneration2016

    • Author(s)
      Suzuki O. Anada T, Kobayashi K, Shiwaku Y
    • Organizer
      6th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      2016-01-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 天然高分子とリン酸八カルシウムの複合体を活用する生体活性型骨補填材の開発2016

    • Author(s)
      鈴木 治
    • Organizer
      2016ライフサイエンスバイオマテリアル研究会
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 骨再生を促進するリン酸八カルシウム(OCP)骨補填材の開発2016

    • Author(s)
      鈴木 治
    • Organizer
      整形外科バイオマテリアル研究会
    • Place of Presentation
      大阪
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Comparative study on early tissue response by synthetic octacalcium phosphate and hydroxyapatite2015

    • Author(s)
      Hirayama B, Anada T, Shiwaku Y, Miyatake N, Tsuchiya K, Nakamura M, Takahashi T, Suzuki O
    • Organizer
      15th AsianBioCeramics symposium
    • Place of Presentation
      東京
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ラット頭蓋冠臨界骨欠損部における多孔性ゼラチンスポンジの骨再生能について2015

    • Author(s)
      江副祐史,神田直典,穴田貴久,小林司史,高橋 哲,鈴木 治
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] リン酸オクタカルシウムによる骨再生能の解明~特に細胞応答性について~2015

    • Author(s)
      平山聞一,穴田貴久,宮武尚央,土屋香織,中村雅典,高橋 哲,鈴木 治
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Octacalcium phosphate materials: Bioactivity and capability in bone and bone-related tissue regeneration2015

    • Author(s)
      Suzuki O, Anada T, Shiwaku Y
    • Organizer
      HKU-Tohoku University 1st Bilateral Dental Symposium -Advanced Prosthodontics and Biomaterials Science
    • Place of Presentation
      Hong Kong
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リン酸オクタカルシウム骨再生材料の埋入早期における生体反応2015

    • Author(s)
      平山聞一,穴田貴久,宮武尚央,土屋香織,中村雅典,高橋 哲,鈴木 治
    • Organizer
      第69回口腔科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 加水分解処理されたリン酸オクタカルシウム(OCP)析出ゼラチン複合担体の生体材料学的評価2015

    • Author(s)
      江副祐史,穴田貴久,山崎元,半田拓人,小林司史,高橋哲,鈴木治
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] リン酸オクタカルシウム/ゼラチン複合体の家兎脛骨骨欠損における骨置換促進能の検討2015

    • Author(s)
      千葉晋平,穴田貴久,齋藤慶介,宮武尚央,鈴木堅太郎,保坂正美,今泉秀樹,井樋栄二,鈴木治
    • Organizer
      第36回東北骨代謝・骨粗鬆症研究会
    • Place of Presentation
      仙台
    • Year and Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新生骨との置換を促進する生体活性型バイオマテリアルの創製と骨再生への応用2014

    • Author(s)
      鈴木 治
    • Organizer
      第5 回 最新の医薬,医療に関するGMP,技術動向を考える会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 骨置換再生能を有するリン酸八カルシウム(OCP)ベース骨代替材料2014

    • Author(s)
      鈴木 治
    • Organizer
      第32回日本骨代謝学会学術集会,産学連携プログラム(あり方委員会企画),外科的手術における最先端の骨移植
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] バイオマテリアルの生体応答とメカニカルストレス2014

    • Author(s)
      鈴木 治, 穴田貴久,益田泰輔
    • Organizer
      第53回日本生体医工学会大会,シンポジウム「メカノバイオロジーによる生理と病態の解明」
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ラット頭蓋冠臨界骨欠損の骨再生におけるゼラチン/OCP 複合体埋入の有効性2014

    • Author(s)
      石河理紗,穴田貴久,佐々木啓一 ,鈴木 治
    • Organizer
      平成26年度春季第63回学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-12 – 2014-04-13
    • Related Report
      2014 Annual Research Report
  • [Book] Calcium: Chemistry, Analysis, Function and Effects. Chapter 8: Using Fluorescent Polyanions to Assay for Osteoclastic Calcium-Resorption Activity2015

    • Author(s)
      Miyazaki T, Suzuki O
    • Total Pages
      640
    • Publisher
      Royal Society of Chemstry
    • Related Report
      2015 Annual Research Report
  • [Book] 「バイオマテリアル研究の最前線」Ca欠損ハイドロキシアパタイトへの転換プロセスが 関与するOCPの骨形成促進作用―OCPの骨伝導能発現のメカニズム―2014

    • Author(s)
      塙 隆夫,新家光雄,鈴木 治,成島尚之,中野貴由,吉川秀樹,石原一彦,中村美穂,高野直樹,多根正和,小林千悟,池田勝彦,上田恭介,富代光陽,岡崎義光,萩原幸司,稗田純子,浜田賢一,仲井正昭
    • Total Pages
      250
    • Publisher
      日本金属学会(編)
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学大学院歯学研究科 顎口腔機能創建学分野HP

    • URL

      http://www.cfe.dent.tohoku.ac.jp

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学大学院歯学研究科 顎口腔機能創建学分野HP

    • URL

      http://www.cfe.dent.tohoku.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学大学院顎口腔機能創建学分野HP

    • URL

      http://www.cfe.dent.tohoku.ac.jp/

    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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