| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
IgG4-related disease (IgG4-RD) is a unique inflammatory disorder. In addition, recent studies have also implicated the Toll-like receptor (TLR) pathway. Here, we examined the expression of TLRs in salivary glands (SGs) from patients with IgG4-RD. In patients with IgG4-RD, TLR7 was overexpressed compared with the other groups. Immunohistochemical analysis confirmed strong infiltration of TLR7-positive cells in the SGs of patients with IgG4-RD. Double immunohistochemical staining showed that TLR7 expression co-localized with CD163+ M2 macrophages. In huTlr7 Tg mice, the focus and fibrosis score in SMGs, pancreas, and lungs were significantly higher than those in wild-type mice. Moreover, the concentration of serum IgG in huTlr7 Tg mice was significantly higher than that in wild-type mice and distinctly increased upon stimulation with TLR7 agonist. Thus, huTlr7 Tg mice could lead to the establishment of a mouse model of IgG4-RD.
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