| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we investigated common molecules which are expressed and function in periodontal tissue and other organs/tissues to understand molecular pathogenesis of periodontal medicine. It was shown that PLAP-1 which is expressed in periodontal ligament and adipose tissue functions as positive regulator for adipogenesis. PLAP-1 KO mice shows the improvement of HFD-induced overweight and significantly high glucose tolerance and enhanced insulin sensitivity compared to WT mice. HFD-induced alveolar bone resorption in PLAP-1 KO mice were also less. In LDS model mouse, in which TGF-β signal is disordered alveolar bone loss by P.g inoculation was significantly increased, compared to WT. The LDS macrophages showed an up-regulated response to LPS compared to that of WT. These results suggest that PLAP-1 plays important roles in HFD-induced obesity and periodontitis and the abnormality of TGF-β signal may accelerate pathogenesis or progress of periodontitis.
|
