| Budget Amount *help |
¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
We succeeded to visualize oxidative stress in brain after inducing occlusal disharmony in a Keap1-dependent oxidative stress detector-luciferase (OKD-LUC) mouse. The stress level was greater in mice with bilateral occlusal disharmony than those with unilateral. The intake of hydrogen-rich water (HW) did not reduce the heme oxygenase-1 (HO-1) gene expression, which is an oxidative stress inhibitor. The visualized oxidative stress level was lower in WH-intake, however the effect was transient.
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