Real-time monitoring of the oxidative stress in brain induced by occlusal disharmony
| Project/Area Number |
26293441
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Morita Manabu 岡山大学, 医歯(薬)学総合研究科, 教授 (40157904)
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| Co-Investigator(Kenkyū-buntansha) |
江國 大輔 岡山大学, 大学病院, 講師 (70346443)
友藤 孝明 岡山大学, 医歯(薬)学総合研究科, 准教授 (80335629)
東 哲司 岡山大学, 医歯(薬)学総合研究科, 助教 (80432649)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 酸化ストレス / 咬合異常 / 抗酸化物質 / 咬合異状 / 加視化 |
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| Outline of Final Research Achievements |
We succeeded to visualize oxidative stress in brain after inducing occlusal disharmony in a Keap1-dependent oxidative stress detector-luciferase (OKD-LUC) mouse. The stress level was greater in mice with bilateral occlusal disharmony than those with unilateral. The intake of hydrogen-rich water (HW) did not reduce the heme oxygenase-1 (HO-1) gene expression, which is an oxidative stress inhibitor. The visualized oxidative stress level was lower in WH-intake, however the effect was transient.
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Report
(4 results)
Research Products
(1 results)
