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Study on correlation of biotic and abiotic factors in vector competency

Research Project

Project/Area Number 26304038
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Veterinary medical science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

Fukumoto Shinya  帯広畜産大学, 原虫病研究センター, 准教授 (50376422)

Co-Investigator(Renkei-kenkyūsha) Aiuchi Daigo  
Research Collaborator Badolo Athanase  
Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywordsベクター / マラリア / ハマダラカ / 殺虫剤耐性 / 感染症
Outline of Final Research Achievements

This study aimed to analyze what factors are important for pathogens transmission, focusing on mosquito-borne diseases such as malaria, in Burkina Faso, West Africa. As a result, it has become clear that insecticide resistance as a biological factor of mosquitoes and the use of insecticides such as pesticides as a non-biological factor have come to an extremely important aspect for malaria control. Although insecticides are important for malaria control, it has been identified that there is a high need for comprehensive and continuous monitoring, including use for agricultural applications.

Academic Significance and Societal Importance of the Research Achievements

ブルキナファソ西部では綿花栽培に使用される農薬である有機リン剤の影響により、マラリアを媒介する蚊が、有機リン剤系殺虫剤に耐性を高い割合で持ちつつあることが明らかとなった。この殺虫剤耐性変異をホモ接合体として持つ個体も発見され注意が必要である。首都ワガドゥーグーではデング熱が問題となっており、その媒介蚊であるネッタイシマカはピレスロイド耐性を示すが有機リン剤に対しては感受性を維持している。これらの結果はブルキナファソにおける蚊媒介性感染症対策指針策定にあたり重要な基礎的知見となると考えられる。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 6 results)

  • [Int'l Joint Research] ワガドゥーグー大学/UFR SVT/Athanase Badolo(ブルキナファソ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ワガドゥーグー大学/国立マラリア研修・研究センター(ブルキナファソ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Unversity of Ouagadougou(Burkina Faso)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] High frequencies of F1534C and V1016I kdr mutations and association with pyrethroid resistance in Aedes aegypti from Somgande; (Ouagadougou), Burkina Faso2019

    • Author(s)
      Aboubacar Sombie, Erisha Saiki, Felix Yameogo, Tatsuya Sakurai, Takahiro Shirozu, Shinya Fukumoto, Antoine Sanon, David Weetman, Philip J. McCall, Hirotaka Kanuka, Athanase Badolo
    • Journal Title

      Tropical Medicine and Health

      Volume: 47 Issue: 1 Pages: 2-2

    • DOI

      10.1186/s41182-018-0134-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adeno-Associated Virus as an Effective Malaria Booster Vaccine Following Adenovirus Priming2019

    • Author(s)
      Yusuf Y, Yoshii T, Iyori M, Yoshida K, Mizukami H, Fukumoto S, Yamamoto DS, Alam A, Emran TB, Amelia F, Islam A, Otsuka H, Takashima E, Tsuboi T, Yoshida S.
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 730-730

    • DOI

      10.3389/fimmu.2019.00730

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a bsd-blasticidin selection system in Plasmodium berghei2018

    • Author(s)
      Akira Soga, Mami Ko-ketsu, Shinya Fukumoto
    • Journal Title

      FEBS Letters

      Volume: 592 Issue: 11 Pages: 1847-1855

    • DOI

      10.1002/1873-3468.13100

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High efficacy in vitro selection procedure for generating transgenic parasites of Plasmodium berghei using an antibiotic toxic to rodent hosts2017

    • Author(s)
      Soga Akira、Bando Hironori、Ko-ketsu Mami、Masuda-Suganuma Hirono、Kawazu Shin-ichiro、Fukumoto Shinya
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 4001-4001

    • DOI

      10.1038/s41598-017-04244-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular characterization of Fasciola flukes obtained from wild sika deer and domestic cattle in Hokkaido, Japan2017

    • Author(s)
      Ichikawa-Seki Madoka、Shiroma Tomoko、Kariya Tatsuya、Nakao Ryo、Ohari Yuma、Hayashi Kei、Fukumoto Shinya
    • Journal Title

      Parasitology International

      Volume: 66 Issue: 5 Pages: 519-521

    • DOI

      10.1016/j.parint.2017.04.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of G119S ace-1 (R) mutation in field-collected Anopheles gambiae mosquitoes using allele-specific loop-mediated isothermal amplification (AS-LAMP) method2015

    • Author(s)
      Badolo, A. Bando, H. Traore, A. Ko-Ketsu, M. Guelbeogo, W. M. Kanuka, H. Ranson, H. Sagnon, N. Fukumoto, S.
    • Journal Title

      Malar J

      Volume: 14 Issue: 1 Pages: 477-477

    • DOI

      10.1186/s12936-015-0968-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Development of high efficacy in vitro drug selection systems for generating transgenic parasite of Plasmodium berghei2018

    • Author(s)
      Akira Soga , Mami Ko-ketsu, Shinya Fukumoto
    • Organizer
      14th International Congress of Parasitology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The identification of phenotypes in Dirofilaria immits-infected Aedes aegypti by comparison with the established strain of the vectorial capacity2018

    • Author(s)
      Takahiro Shirozu, Nobuaki Seki, Akira Soga, Yu-ki Morishita, Mami Ko-ketsu, Shinya Fukumoto
    • Organizer
      14th International Congress of Parasitology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dirofilaria immitis抵抗性Aedes aegypti系統における感染阻害因子の同定2018

    • Author(s)
      白水貴大、関信彰、曽賀晃、森下雄貴、纐纈摩美、福本晋也
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Filarial nematode Dirofilaria immitis diverts thermoregulation to developmental transition following transmission by Aedes mosquito2017

    • Author(s)
      S. Fukumoto, A. Yoshimura, H. Kanuka
    • Organizer
      Molecular Helminthology: An Integrated Approach Conference 2017
    • Place of Presentation
      Hyannis (USA)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 宿主毒性薬剤選択系を用いたPlasmodiuim berghei遺伝子ターゲティング法の確立2017

    • Author(s)
      曽賀晃、纐纈摩美、福本晋也
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of high efficacy in vitro drug selection method for sequential genetic manipulation of Plasmodium berghei2017

    • Author(s)
      Akira Soga ; Mami Ko-ketsu ; Shinya Fukumoto
    • Organizer
      WAAVP2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thermoregulation controls the developmental host transition in filarial parasites Dirofilaria immitis2017

    • Author(s)
      Shinya Fukumoto ; Aya Yoshimura ; Hirotaka Kanuka
    • Organizer
      WAAVP2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ネズミマラリア原虫Plasmodium bergheiにおけるin vitro薬剤選択法の改良2017

    • Author(s)
      曽賀晃、纐纈摩美、福本晋也
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 宿主毒性薬剤選択系を用いたネズミマラリア原虫効率的遺伝子操作法の開発2017

    • Author(s)
      曽賀晃、纐纈摩美、福本晋也
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 哺乳類宿主毒性抗生剤を利用したPlasmodium berghei多重変異体作製技術の開発2016

    • Author(s)
      曽賀晃、纐纈摩美、福本晋也
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] In vitro哺乳動物毒性マーカーシステムの応用によるマウスマラリアモデル 多重変異体選択技術の開発2016

    • Author(s)
      曽賀晃、纐纈摩美、福本晋也
    • Organizer
      第159回日本獣医学会
    • Place of Presentation
      日本大学(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミノ酸摂取量の調整によるマラリア制御の可能性2016

    • Author(s)
      齊木 選射、長尾 健児、石上 盛敏、福本 晋也、クルドゥスッドゥ スリヴィッチャ、 櫻井 達也、坂内 慎、狩野 繁之、嘉糠 洋陸
    • Organizer
      第85回日本寄生虫学会大会
    • Place of Presentation
      宮崎県宮崎市、宮崎市民プラザ
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] In vitro-puromycinシステムによる高効率遺伝子組換えPlasmodium berghei選択法の開発2015

    • Author(s)
      曽賀晃、纐纈摩美、福本晋也
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市、神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comparison of loop-mediated isothermal amplification method (LAMP) and RT-PCR methods for Plasmodium faclciparum detection in field-collected Anopheles gambiae mosquitoes2015

    • Author(s)
      Athanase Badolo, Moussa W. Guelbeogo, N’Falé Sagnon, Shiniya Fukumoto and Hirotaka Kanuka
    • Organizer
      EMBO Conference on Molecular and Population Biology of Mosquitoes and Other Disease Vectors: Current, Resurgent and Emerging Diseases
    • Place of Presentation
      Kolymbari, Greece
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フィールド採集ハマダラカからの等温遺伝子増幅法による熱帯熱マラリア原虫検出法の検討2015

    • Author(s)
      曽賀晃、アタナセ バドロ、纐纈摩美、福本晋也
    • Organizer
      第67回日本衛生動物学会
    • Place of Presentation
      金沢大学宝町キャンパス(石川県金沢市)
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] LAMP法によるG119S Ace1R変異検出法の開発と西アフリカ-ブルキナファソ採集ガンビアハマダラカでの検証2015

    • Author(s)
      アタナセ バドロ、纐纈摩美、福本晋也
    • Organizer
      第67回日本衛生動物学会
    • Place of Presentation
      金沢大学宝町キャンパス(石川県金沢市)
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2020-03-30  

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