| Project/Area Number |
26305001
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大崎 愛弓 日本大学, 文理学部, 准教授 (50161360)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAIA MIDORI 千葉大学, 大学院薬学研究院, 准教授 (40373261)
TOUME KAZUFUMI 千葉大学, 大学院薬学研究院, 助教 (80563981)
ISHIKAWA NAOKI 千葉大学, 大学院薬学研究院, 助教 (20748826)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 薬学 / シグナル伝達 / 生理活性 / 有機化学 / 植物 / 生体分子 |
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| Outline of Final Research Achievements |
In 2014-2017 (fiscal year), an international collaboration project on field-study of natural medicinal resources in Bangladesh was carried out between the representative of this research project (Masami Ishibashi) and the counterpart in Bangladesh headed by Professor Samir K. Kumar of Khulna University. As a result, a large number of plant samples, including field-characteristic tropical species as well as locally used medicinal herbs. Extracts of these materials were subjected to screening tests against disease-signals such as Wnt, hedgehog, TRAIL, Notch, and BMI1, and from active samples several new bioactive natural products were isolated. Mechanisms of the activities were further examined at molecular levels for selected compounds.
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