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Investigation of benthic marine organisms in Indonesia and development of new medical resources

Research Project

Project/Area Number 26305002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Natural medicines
Research InstitutionOsaka University

Principal Investigator

ARAI Masayoshi  大阪大学, 薬学研究科, 特任教授(常勤) (80311231)

Co-Investigator(Renkei-kenkyūsha) KOBAYASHI Motomasa  大阪大学, 大学院・薬学研究科, 招へい教授 (40116033)
TANAKA Junichi  琉球大学, 理学部, 教授 (20163529)
AOKI Shunji  兵庫医療大学, 薬学部, 教授 (60252699)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords海洋生物 / 海綿 / 海洋微生物 / インドネシア / 医薬シーズ / 活性天然物 / 海洋薬物資源 / 底生海洋生物
Outline of Final Research Achievements

In order to develop the new medicinal resources, 265 samples of benthic marine organisms were collected from the coral reefs surounding Aceh and Sabang Island in northern part of Sumatra Island, Mentawai in the western part of Sumatra Island, and Plumaka Island of Thousand Islands (northern part of Java Island). For the purpose of conservation and sustainable use of resources, we conserved the total genome of collected benthic marine organisms, and isolated 224 kinds of microorganisms from benthic marine organisms. In addition to preserving benthic marine organisms as specimens, information of inhabitation, environments, and morphological features of benthic marine organisms were summarized and listed based on the pictures of marine organisms under the water. Moreover, the extracts were prepared from marine organisms and cultured microbes, and then information of biological activities and bioactive constituents were also listed.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (38 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (4 results) Journal Article (13 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 13 results,  Acknowledgement Compliant: 9 results,  Open Access: 2 results) Presentation (18 results) (of which Int'l Joint Research: 4 results,  Invited: 9 results) Remarks (3 results)

  • [Int'l Joint Research] ランプン大学(インドネシア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Lampung University(インドネシア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Lampung University(インドネシア)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of KwaZulu Natal(南アフリカ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II2017

    • Author(s)
      Arai Masayoshi、Shin Dayoung、Kamiya Kentaro、Ishida Ryosuke、Setiawan Andi、Kotoku Naoyuki、Kobayashi Motomasa
    • Journal Title

      Journal of Natural Medicines

      Volume: 71 Issue: 1 Pages: 44-49

    • DOI

      10.1007/s11418-016-1025-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biakamides A-D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation2017

    • Author(s)
      Naoyuki Kotoku, Ryosuke Ishida, Hirokazu Matsumoto, Masayoshi Arai, Kazunari Toda, Andi Setiawan, Osamu Muraoka, and Motomasa Kobayashi
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 82 Issue: 3 Pages: 1705-1718

    • DOI

      10.1021/acs.joc.6b02948

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anti-dormant mycobacterial activity of viomellein and xanthomegnin, naphthoquinone dimers produced by marine-derived Aspergillus sp.2017

    • Author(s)
      K. Kamiya, M. Arai, A. Setiawan, M. Kobayashi
    • Journal Title

      Nat. Prod. Commun.

      Volume: 12 Pages: 579-582

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Activation of cryptic phthoxazolin A production in Streptomyces avermitilis by the disruption of autoregulator-receptor homologue AvaR3.2017

    • Author(s)
      D.A. Suroto, S. Kitani, K.T. Miyamoto, Y. Sakihama, M. Arai, H. Ikeda, T. Nihira
    • Journal Title

      J. Biosci. Bioeng.

      Volume: 124 Issue: 6 Pages: 611-617

    • DOI

      10.1016/j.jbiosc.2017.06.014

    • NAID

      40021420041

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Furospinosulin-1, marine spongean furanosesterterpene, suppresses the growth of hypoxia-adapted cancer cells by binding to transcriptional regulators p54nrb and LEDGF/p75.2016

    • Author(s)
      Arai, M.; Kawachi, T.; Kotoku, N.; Nakata, C.; Kamada, H.; Tsunoda, S.; Tsutsumi, Y.; Endo, H.; Inoue, M.; Sato, H.; Kobayashi, M.
    • Journal Title

      ChemBioChem

      Volume: 17 Issue: 2 Pages: 181-189

    • DOI

      10.1002/cbic.201500519

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anti-dormant mycobacterial activity and target molecule of melophlins, tetramic acid derivatives isolated from a marine sponge of Melophlus sp.2016

    • Author(s)
      M. Arai, Y. Yamano, K. Kamiya, A. Setiawan, M. Kobayashi
    • Journal Title

      J. Nat. Med.

      Volume: 70 Issue: 3 Pages: 467-475

    • DOI

      10.1007/s11418-016-1005-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] <i>N</i>-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of <i>Xestospongia</i> sp.2016

    • Author(s)
      M. Arai, K. Kamiya, D. Shin, H. Matsumoto, T. Hisa, A. Setiawan, N. Kotoku, M. Kobayashi
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 7 Pages: 766-771

    • DOI

      10.1248/cpb.c16-00118

    • NAID

      130005160059

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] New 3-alkylpyridine alkaloid, N-methylniphatyne A as an inhibitor of cancer cells adapted to nutrient starvation from an Indonesia marine sponge of Xestospongia sp.2016

    • Author(s)
      Arai, M.; Kamiya, K.; Shin, D.; Matsumoto, H.; Hisa, T.; Setiawan, A.; Kotoku, N.; Kobayashi, M.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Search for Anti-angiogenic Substances from Natural Sources2016

    • Author(s)
      Kotoku, N.; Arai, M.; Kobayashi, M.
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 2 Pages: 128-134

    • DOI

      10.1248/cpb.c15-00744

    • NAID

      130005121723

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.2015

    • Author(s)
      Arai, M.; Kamiya, K.; Pruksakorn, P.; Sumii, Y.; Kotoku, N.; Joubert, J.-P.; Moodley, P.; Han, C.; Shin, D.; Kobayashi, M.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 13 Pages: 3534-3541

    • DOI

      10.1016/j.bmc.2015.04.033

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of target protein of agelasine D, a marine spongean diterpene alkaloid, as an anti-dormant mycobacterial substance.2014

    • Author(s)
      M. Arai, Y. Yamano, A. Setiawan, M. Kobayashi
    • Journal Title

      ChemBioChem

      Volume: 15 Issue: 1 Pages: 117-123

    • DOI

      10.1002/cbic.201300470

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.2014

    • Author(s)
      M. Arai, T. Kawachi, H. Sato, A. Setiawan, M. Kobayashi
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Issue: 14 Pages: 3155-3157

    • DOI

      10.1016/j.bmcl.2014.04.116

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances.2014

    • Author(s)
      M. Arai, C. Han, Y. Yamano, A. Setiawan M. Kobayashi
    • Journal Title

      J. Nat. Med.

      Volume: 68 Issue: 2 Pages: 372-376

    • DOI

      10.1007/s11418-013-0811-y

    • NAID

      40020023317

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Exploring new medicinal seeds and drug targets from marine resources.2018

    • Author(s)
      Masayoshi Arai
    • Organizer
      JOINT SYMPOSIUM OF OSAKA UNIVERSITY WITH HIGHER EDUCATIONAL INSTITUTIONS OF BRUNEI DARUSSALAM
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新規海洋天然物biakamide類の栄養飢餓環境選択的がん細胞増殖阻害活性とその作用メカニズム2017

    • Author(s)
      ○石田良典, 古徳直之, 荒井雅吉
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 海洋天然物の魅力と創薬研究への応用2017

    • Author(s)
      荒井雅吉
    • Organizer
      第40回 新適塾 「未来創薬への誘い」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 海洋由来Trichoderma属真菌からの抗潜在性結核物質の探索2016

    • Author(s)
      荒井雅吉,伊藤みなみ,神谷謙太朗,小林資正
    • Organizer
      日本生薬学会第63年会(富山)
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 医薬シーズの開拓を目指した海洋生物資源からの活性天然物の探索2016

    • Author(s)
      小林資正
    • Organizer
      日本生薬学会第63年会(富山)
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 潜在性結核菌に対する抗菌物質nybomycinの標的分子解析2016

    • Author(s)
      荒井雅吉,◯神谷謙太朗,住井裕司,申多英,Patamaporn Pruksakorn,韓智秀,古徳直之,小林資正
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Exploring novel drug target for cancer chemotherapy by the study of furospinosulin-1, a hypoxia-selective growth inhibitor against cancer cells2016

    • Author(s)
      Masayoshi Arai
    • Organizer
      The 6th Queenstown Molecular Biology Meeting in Shanghai
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Target Identification of Anti-mycobacterial Substance using Transformant Library of Mycobacteria2016

    • Author(s)
      Masayoshi Arai
    • Organizer
      The 8th Japan-Korea Chemical Biology Symposium
    • Place of Presentation
      パシフィックホテル沖縄 (沖縄)
    • Year and Date
      2016-01-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 海綿由来アルカロイドaaptamine類の潜在性結核菌に対する抗菌活性2016

    • Author(s)
      荒井雅吉,神谷謙太朗,韓智秀,山野 喜,住井裕司,中村健彦,古徳直之,小林資正
    • Organizer
      第66回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学(大阪府高槻市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Target identification of agelasine D, a marine spongean diterpene alkaloid, as an antidormant mycobacterial substance.2015

    • Author(s)
      ◯Masayoshi Arai, Yoshi Yamano, Andi Setiawan and Motomasa Kobayashi
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Hawaii (USA)
    • Year and Date
      2015-12-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 海綿由来環状デプシペプチドarenastatin Aの新規結合タンパク質の同定2015

    • Author(s)
      ◯荒井雅吉,河内崇志,高市伸宏,馬田哲也,古徳直之,小林資正
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川県民ホール(横浜)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Phenotypic Screeningによる 活性天然物探索と新規薬剤標的の開拓2015

    • Author(s)
      荒井雅吉
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性天然物の標的分子解析による 新規薬剤標的の探索2015

    • Author(s)
      荒井雅吉
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 腫瘍内細胞の表現型変化を制御する海洋天然物からの創薬とケミカルバイオロジー研究2014

    • Author(s)
      荒井雅吉
    • Organizer
      第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2014-11-27 – 2014-11-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] グルコース飢餓環境選択的がん細胞増殖阻害作用を有する新規ポリケチド類の化学構造と生物活性2014

    • Author(s)
      古徳直之、戸田和成、荒井雅吉、石田良典、松本紘和、村岡 修、小林資正
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知県立県民文化ホール(高知県)
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 海洋由来放線菌が産生するnybomycinの潜在性結核菌に対する抗菌活性とその作用メカニズム2014

    • Author(s)
      神谷謙太朗、荒井雅吉、住井裕司、申 多英、Patamaporn Pruksakorn、韓 智秀、古徳直之、小林資正
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡大学(福岡市)
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Phenotypic Screening and Chemical Biology for Exploring New Medicinal Seeds and Drug Targets2014

    • Author(s)
      Masayoshi Arai
    • Organizer
      第8回日中韓生薬学合同シンポジウム
    • Place of Presentation
      福岡大学(福岡市)
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 海洋天然物furospinosulin-1を利用する新規がん細胞低酸素適応因子の創出2014

    • Author(s)
      河内崇志、荒井雅吉、古徳直之、小林資正
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台市情報・産業プラザ等(仙台市)
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Remarks] 大阪大学大学院 薬学研究科 天然物化学分野ホームページ

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b012/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 大阪大学大学院 薬学研究科 天然物化学分野 ホームページ

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b012/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 大阪大学大学院薬学研究科 天然物化学分野 ホームページ

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b012/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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