Strategy for allergic diseases treatment based on the function of ayurvedic medicines
| Project/Area Number |
26305004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Natural medicines
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| Research Institution | The University of Tokushima |
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Principal Investigator |
FUKUI Hiroyuki 徳島大学, 大学院医歯薬学研究部, 特任教授 (90112052)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 花粉症 / アレルギー性鼻炎 / アレルギー疾患 / ヒスタミン / 天然物医薬 / 疾患感受性遺伝子 / 細胞内シグナル / PKCδ / アレルギー / 細胞内シグナル分子 / 積極的併用療法 / 分子標的薬 |
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| Outline of Final Research Achievements |
A novel benzofuran compound 4-methoxybenzofuran-5-carboxamide (HMBC) was identified as an active ingredient from anti-allergic ayurvedic medicine Tephresia purpurea. MBCA suppressed H1 R gene expression through suppression of PKCd activation. In addition, MBCA isomer showed stronger H1R gene expression inhibitory activity than MBCA. In allergy model rats, it was found that MBCA ameliorates nasal symptoms through suppressing expression of H1R gene and Th2 cytokine gene such as IL-4, IL-5 of nasal mucosa. Furthermore, since MBCA suppresses IL-33 gene expression, it is suggested that not only acute symptoms of allergic rhinitis but also chronic symptoms may be improved by MBCA.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] The isolation and synthesis of a novel benzofuran compound from Tephrosia purpurea, and the synthesis of several related derivatives, which suppress histamine H1 receptor gene expression.2015
Author(s)
Shill MC, Das AK, Itou T, Karmakar S, Mukherjee PK, Mizuguchi H, Kashiwada Y, Fukui H, Nemoto H.
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Journal Title
Bioorg Med Chem
Volume: 23
Pages: 6869-6874
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathway.2015
Author(s)
hill MC, Mizuguchi H, Karmakar S, Kadota T, Mukherjee PK, Kitamura T, Kashiwada Y, Nemoto H, Takeda N, Fukui H.
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Journal Title
Int Immunopharmacol
Volume: 30
Pages: 18-26
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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