Identification of artemisinin resistance in Thai-Myanmar border region
| Project/Area Number |
26305009
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Tokyo Medical and Dental University (2017)
Mie University (2014-2016) |
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Principal Investigator |
IWANAGA Shiroh 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20314510)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | マラリア / アルテミシニン / 薬剤耐性 / 感染症 |
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| Outline of Final Research Achievements |
In this study, we collected the malaria patient bloods in Thai-Myanmar and established 255 of the cultivable parasite strain. Next, we established the detection method for artemisinin resistance. In this method, we cultured the parasites in the presence of 5 nM of artemisinin for 96 hours and evaluated their resistance in terms of their survivals. By using this method, we identified 7 artemisinin resistant parasites from those obtained cultivable parasites. In contrast to the Cambodian resistant parasite, one of them did not show the resistance at the ring stage. This result indicated that Thai-Myanmar resistant parasite was different from the Cambodian resistant parasites. Furthermore, we identified the gene responsible for redox system as drug resistance gene. This result suggested that the change of the redox condition in the cell may involved in the artemisinin resistance.
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Report
(5 results)
Research Products
(9 results)
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[Journal Article] Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors2017
Author(s)
Saito Fumiji、Hirayasu Kouyuki、Satoh Takeshi、Wang Christian W.、Lusingu John、Arimori Takao、Shida Kyoko、Palacpac Nirianne Marie Q.、Itagaki Sawako、Iwanaga Shiroh、Takashima Eizo、Tsuboi Takafumi、Kohyama Masako、Suenaga Tadahiro、Colonna Marco、Takagi Junichi、Lavstsen Thomas、Horii Toshihiro、Arase Hisashi
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Journal Title
Nature.
Volume: 552
Issue: 7683
Pages: 101-105
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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