The research in Kenya for the development a diagnostic method of asymptomatic M tuberculosis infection and disease progression
| Project/Area Number |
26305017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
阿戸 学 国立感染症研究所, ハンセン病研究センター 感染制御部, 部長 (20392318)
濱野 真二郎 長崎大学, 熱帯医学研究所, 教授 (70294915)
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| Co-Investigator(Renkei-kenkyūsha) |
KANEKO Satoshi 長崎大学, 熱帯医学研究所, 教授 (00342907)
FUJII Yoshito 長崎大学, 熱帯医学研究所, 准教授 (40347498)
OKA Mayuko (OZEKI Yuriko) 京都府立大学, 生命環境科学研究科, 准教授 (00169301)
MAEKURA Ryoji 刀根山病院, 臨床研究部, 副院長 (60423886)
ICHINOSE Yoshio 長崎大学, 熱帯医学研究所, 教授 (70176296)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 結核 / 感染 / マクロファージ / ケニア / 寄生虫 / コレステロール / HDL / アフリカ / 診断 / 栄養 / 途上国 / 潜在性結核 / HIV |
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| Outline of Final Research Achievements |
This study was performed in tuberculosis-endemic area in Kenya to address molecular mechanisms of latency and know the fundamental knowledge for prediction of disease progression. We found some M. tuberculosis antigens are well recognized by host immune response, while some other antigens were done in individuals with asymptomatic infection. This suggested that detection of the immune responses to M. tuberculosis antigens can be applied for diagnosis of asymptomatic infection and disease progression.
We also found elevated HDL-cholesterol levels in M. tuberculosis-infected individuals. We found human macrophages produces TNF-alpha, a host protective cytokine against tuberculosis, depending on TLR2 upon M. tuberculosis infection. And HDL suppresses TLR2 expression and its cellar signaling. These suggest that higher HDL level may be risk of both asymptomatic and active tuberculosis.
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Report
(5 results)
Research Products
(52 results)
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[Journal Article] High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages.2018
Author(s)
Inoue M, Niki M, Ozeki Y, Nagi S, Chadeka EA, Yamaguchi T, Osada-Oka M, Ono K, Oda T, Mwende F, Kaneko Y, Matsumoto M, Kaneko S, Ichinose Y, Njenga SM, Hamano S, Matsumoto S.
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Journal Title
Sci Rep
Volume: 8
Issue: 1
Pages: 6736-6736
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya.2017
Author(s)
Chadeka EA, Nagi S, Sunahara T, Cheruiyot NB, Bahati F, Ozeki Y, Inoue M, Osada-Oka M, Okabe M, Hirayama Y, Changoma M, Adachi K, Mwende F, Kikuchi M, Nakamura R, Kalenda YDJ, Kaneko S, Hirayama K, Shimada M, Ichinose Y, Njenga SM, Matsumoto S, Hamano S.
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Journal Title
PLoS Negl Trop Dis
Volume: 11
Issue: 9
Pages: e0005872-e0005872
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clin2015
Author(s)
Niki, M., M. Suzukawa, S. Akashi, H. Nagai, K. Ohta, M. Inoue, M. Niki, Y. Kaneko, K. Morimoto, A. Kurashima, S. Kitada, S. Matsumoto, K. Suzuki, and Y. Hoshino
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Gueren2015
Author(s)
Ozeki, Y., M. Igarashi, M. Doe, A. Tamaru, N. Kinoshita, Y. Ogura, T. Iwamoto, R. Sawa, M. Umekita, S. Enany, Y. Nishiuchi, M. Osada-Oka, T. Hayashi, M. Niki, Y. Tateishi, M. Hatano, and S. Matsumoto
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models.2014
Author(s)
Fujii Y, Kaneko S, Nzou SM, Mwau M, Njenga SM, Tanigawa C, Kimotho J, Mwangi AW, Kiche I, Matsumoto S, Niki M, Osada-Oka M, Ichinose Y, Inoue M, Itoh M, Tachibana H, Ishii K, Tsuboi T, Yoshida LM, Mondal D, Haque R, Hamano S, Changoma M, Hoshi T, Kamo K, Karama M, Miura M, Hirayama K.
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Journal Title
PLoS Negl Trop Dis
Volume: 8
Issue: 7
Pages: 1-15
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Risk Factors and Spatial Distributions of Schistosoma mansoni infection among Primary School Children in Mbita, western Kenya2014
Author(s)
Sachiyo Nagi, Evans Chadeka, Toshihiko Sunahara, Faith Mutungi, Yombo K. Dan Justin, Satoshi Kaneko, Yoshio Ichinose, Sohkichi Mastumoto, Sammy M. Njenga, Masahiro Hashizume, Masaaki Shimada and Shinjiro Hamano
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Journal Title
PLoS Neglected Tropical Disease
Volume: 8
Issue: 7
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] シフェラーゼ発現リコンビナントBCGによる新規結核薬の迅速スクリーニング系の確立と実践2016
Author(s)
尾関 百合子, 山口 雄大, Shymaa Enany, 五十嵐 雅之, 西内 由紀子, 岡 真優子, 岩本 朋忠, 小椋 義俊, 林 哲也, 立石 善隆, 西山 晃史, 松本 壮吉
Organizer
日本細菌学会総会
Place of Presentation
大阪国際交流センター（大阪市天王寺区）
Year and Date
2016-03-23
Related Report
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[Presentation] 潜在期結核菌抗原の精製と感染診断への応用2016
Author(s)
西田 由貴子, 北所 健悟, 尾関 百合子, 立石 善隆, 井上 学, 仁木 満美子, 金子 幸弘, 松本 壮吉
Organizer
日本細菌学会総会
Place of Presentation
大阪国際交流センター（大阪市天王寺区）
Year and Date
2016-03-23
Related Report
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