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Epidemiological study on the effects of industrial nanomaterials on cardiovascular system

Research Project

Project/Area Number 26305023
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Hygiene and public health
Research InstitutionJichi Medical University (2017-2018)
Mie University (2014-2016)

Principal Investigator

Sahoko Ichihara  自治医科大学, 医学部, 教授 (20378326)

Co-Investigator(Kenkyū-buntansha) 市原 学  東京理科大学, 薬学部薬学科, 教授 (90252238)
平工 雄介  三重大学, 医学(系)研究科(研究院), 講師 (30324510)
Research Collaborator Li Weihua  
Huang Zhenlie  
Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywords労働衛生学 / 曝露評価 / ナノ粒子 / 健康影響 / 工場調査 / ナノマテリアル / 心血管系 / 産業衛生 / ナノ素材 / 衛生学 / 粒子 / 心毒性 / 労働衛生 / 環境衛生 / 循環器系 / 中国
Outline of Final Research Achievements

Metal oxide nanoparticles are widely used in industry, cosmetics, and biomedicine. However, the effects of exposure to these nanoparticles on the cardiorespiratory function remain unknown. The objective of this study was to survey workplace exposure levels and health effects of workers exposed to nano-TiO2 or nano-CaCO3. The study showed that exposure to particles with a diameter <300 nm might affect heart rate variability in workers handling TiO2 particles. The results highlight the need to investigate the possible impact of exposure to nano-scaled particles on the autonomic nervous system. In addition, long-term and high-leveled CaCO3 particles exposure can induce pulmonary hypofunction in workers. Thus, lung function examination is suggested for occupational populations with nano-CaCO3 exposure.

Academic Significance and Societal Importance of the Research Achievements

ナノ材料は、新たな物質・材料としてその応用性が期待されているが、新たな物性を持つため、ヒトに対する未知の有害性リスクを有する可能性が懸念されている。本研究の成果より、今後、ナノサイズレベルの粒子の心臓の自律神経系に対する影響を調査していく必要があることが明らかになった。また、炭酸カルシウムナノ粒子曝露を伴う工場労働者には、肺機能検査を定期的に受け、経過を観察していくことが必須であることを把握したと同時に、ナノレベルの粒子の健康影響に関し、更なる調査が必要であることが確認された。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (56 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (5 results) Journal Article (17 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 17 results,  Open Access: 11 results,  Acknowledgement Compliant: 2 results) Presentation (34 results) (of which Int'l Joint Research: 13 results)

  • [Int'l Joint Research] 広東省職業病防治院/広東省婦幼保健院(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 広東省職業病防治院/広東省婦幼保健院(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 労働医学研究所(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 広東省職業病防治院(中国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 上海市計画生育科学研究所/広東省職業病防治院(中国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test2019

    • Author(s)
      Vranic Sandra、Shimada Yasuhito、Ichihara Sahoko、Kimata Masayuki、Wu Wenting、Tanaka Toshio、Boland Sonja、Tran Lang、Ichihara Gaku
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 4 Pages: 882-882

    • DOI

      10.3390/ijms20040882

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exposure of Mice to 1,2-Dichloropropane Induces CYP450-Dependent Proliferation and Apoptosis of Cholangiocytes.2018

    • Author(s)
      Zong C, Zhang X, Huang C, Chang J, Garner E, Sakurai T, Kato M, Ichihara S, Ichihara G.
    • Journal Title

      Toxicol Sci

      Volume: 162 Issue: 2 Pages: 559-69

    • DOI

      10.1093/toxsci/kfx272

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MicroRNAs as Potential Mediators for Cigarette Smoking Induced Atherosclerosis2018

    • Author(s)
      Yokoyama Yuka、Mise Nathan、Suzuki Yuka、Tada-Oikawa Saeko、Izuoka Kiyora、Zhang Lingyi、Zong Cai、Takai Akira、Yamada Yoshiji、Ichihara Sahoko
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 4 Pages: 1097-1097

    • DOI

      10.3390/ijms19041097

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers: a cross-sectional study2018

    • Author(s)
      Li Guoliang、Liang Lihong、Yang Jingchao、Zeng Lihai、Xie Zhiwei、Zhong Yizhou、Ruan Xiaolin、Dong Ming、Yang Zhanhong、Lai Guanchao、Huang Weixin、Yang Aichu、Chen Jiabing、Wu Banghua、Xu Huaming、Meng Dezhi、Hu Shijie、Xia Lihua、Yang Xingfen、Li Laiyu、Ichihara Sahoko、Ichihara Gaku、Huang Hanlin、Huang Zhenlie
    • Journal Title

      Nanotoxicology

      Volume: 12 Issue: 6 Pages: 571-585

    • DOI

      10.1080/17435390.2018.1465606

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Proteomic profiling of exosomal proteins for blood-based biomarkers in Parkinson's Disease.2018

    • Author(s)
      Kitamura Y, Kojima M, Kurosawa T, Sasaki R, Ichihara S, Hiraku Y, Tomimoto H, Murata M, Oikawa S.
    • Journal Title

      Neuroscience

      Volume: 392 Pages: 121-128

    • DOI

      10.1016/j.neuroscience.2018.09.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NF-κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1β production: Inhibition of the PM2.5-induced inflammation model.2018

    • Author(s)
      Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.
    • Journal Title

      Mol Med Rep

      Volume: 18 Pages: 5279-5285

    • DOI

      10.3892/mmr.2018.9533

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Titanium dioxide particle type and concentration influence the inflammatory response in Caco-2 cells2016

    • Author(s)
      Tada-Oikawa S, Ichihara G, Fukatsu H, Shimanuki Y, Tanaka N, Suzuki Y, Murakami M, Izuoka K, Chang J, Wu W, Yamada Y, Ichihara S
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 17 Issue: 4 Pages: 576-576

    • DOI

      10.3390/ijms17040576

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of 4-week inhalation exposure to 1-bromopropane on blood pressure in rats2016

    • Author(s)
      Huang F, Ichihara S, Yamada Y, Banu S, Ichihara G
    • Journal Title

      J Appl Toxicol

      Volume: 37 Issue: 3 Pages: 331-338

    • DOI

      10.1002/jat.3364

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Single- and double-wall carbon nanotubes enhance atherosclerogenesis by promoting monocyte adhesion to endothelial cells and endothelial progenitor cell dysfunction2016

    • Author(s)
      Suzuki Y, Tada-Oikawa S, Hayashi Y, Izuoka K, Kataoka M, Ichikawa S, Wu W, Ichihara G, Ichihara S
    • Journal Title

      Particle and Fibre Toxicology

      Volume: 13 Issue: 1 Pages: 54-54

    • DOI

      10.1186/s12989-016-0166-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exposure assessment and heart rate variability monitoring in workers handling titanium dioxide particles-a pilot study.2016

    • Author(s)
      Ichihara S, Li W, Omura S, Fujitani Y, Liu Y, Wang Q, Hiraku Y, Hisanaga N, Ding X, Maynard A, Kobayashi T, Ichihara G.
    • Journal Title

      Journal of Nano Research

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Zn(II) released from zinc oxide nano/micro particles was involved in the attenuation of vasculogenesis in human endothelial colony-forming cells.2015

    • Author(s)
      Tada-Oikawa S, Ichihara G, Suzuki Y, Izuoka K, Yamada Y, Mishima T, Ichihara S.
    • Journal Title

      Toxicology Reports

      Volume: 2 Pages: 692-701

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hippocampal phosphoproteomics of F344 rats exposed to 1-bromopropane.2015

    • Author(s)
      Huang Z, Ichihara S, Oikawa S, Chang J, Zhang L, Hu S, Huang H, Ichihara G.
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 282 Issue: 2 Pages: 151-160

    • DOI

      10.1016/j.taap.2014.10.016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish.2015

    • Author(s)
      Chang J, Ichihara G, Shimada S, Tada-Oikawa S, Suzuki Y, Radwa S, Kato M, Tanaka T, Ichihara S.
    • Journal Title

      J Nanosci Nanotechnol

      Volume: 15 Pages: 2140-2147

    • NAID

      130004676483

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zn(II) released from zinc oxide nano/micro particles was involved in the attenuation of vasculogenesis in human endothelial colony-forming cells.2015

    • Author(s)
      Tada-Oikawa S, Ichihara G, Suzuki Y, Izuoka K, Yamada Y, Mishima T, Ichihara S.
    • Journal Title

      Toxicol Rep

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zinc oxide nanoparticles induce migration and adhesion of monocytes to endothelial cells and accelerate foam cell formation.2014

    • Author(s)
      Suzuki Y, Tada-Oikawa S, Ichihara G, Yabata M, Izuoka K, Suzuki M, Sakai K, Ichihara S.
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: in press Issue: 1 Pages: 16-25

    • DOI

      10.1016/j.taap.2014.04.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice.2014

    • Author(s)
      Yajima I, Iida M, Kumasaka MY, Omata Y, Ohgami N, Chang J, Ichihara S, Hori M, Kato M.
    • Journal Title

      Exp Dermatol

      Volume: 23 Issue: 6 Pages: 424-425

    • DOI

      10.1111/exd.12415

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synergistic effect of exposure to zinc oxide nanoparticle on inflammatory response to bleomycin-induced pulmonary fibrosis in mice2014

    • Author(s)
      W. Wu, G. Ichihara, N. Hashimoto, Y. Hasegawa, Y. Hayashi, S. Tada-Oikawa, Y. Suzuki, J. Chang, M. Kato, CN. D'Alessandro-Gabazza, EC. Gabazza, S. Ichihara
    • Journal Title

      Int J Mol Sci

      Volume: 16 Issue: 1 Pages: 660-676

    • DOI

      10.3390/ijms16010660

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ジクロロプロパンはマクロファージ共存下胆管細胞の遺伝子改変酵素mRNA発現を誘導する2018

    • Author(s)
      宗才、木村優介、木下和生、高巣成惟、張驍、櫻井敏博、園藤吟史、市原佐保子、市原学
    • Organizer
      第91回日本産業衛生学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 1、2-DCP曝露マウスにおけるP450依存的なタンパク発現量変化の網羅的解析2018

    • Author(s)
      森川浩太、張驍、森有利絵、宗才、市原佐保子、及川伸二、市原学
    • Organizer
      第91回日本産業衛生学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シリカナノ粒子の表面修飾とアポトーシス誘導能に関する研究2018

    • Author(s)
      竹内咲恵、サンドラ ブラニッチ、渡邊英里、長田百合果、平野明穂、櫻井敏博、佐藤聡、市原佐保子、ウ ウェンティン、ラン トラン、ソニア ボーランド、市原学
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of physicochemical characteristics of nano-sized TiO2 on enhancement of atherosclerogenesis2018

    • Author(s)
      Ichihara S, Suzuki Y, Hayashida A, Watanabe E, Osada Y, Furutani T, Izuoka K, Ichihara G
    • Organizer
      Nanotox 2018 - 9th International Conference on Nanotoxicology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exposure assessment of barium sulfate particles in a factory2018

    • Author(s)
      Ichihara G, Huang Z, Ichihara S, Fujitani Y, Hirano H, Takeuch S, Hirano A, Huang H
    • Organizer
      Nano Tox 2018-9th International Conference on Nanotoxicology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of Nrf2 in inJammatory response of mice to zinc oxide nanoparticle2018

    • Author(s)
      Sehsah R, Wu W, Ichihara S, Hashimoto N, Hasegawa Y, Ito K, Yamamoto; M, Ali Elsayed A, El-Bestar S, Kamel K, Ichihara G
    • Organizer
      Nano Tox 2018-9th International Conference on Nanotoxicology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Surface modification alters cytotoxicity of silica nanoparticles.2018

    • Author(s)
      Vranic S, Watanabe E, Osada Y, Takeuchi S, Hirano A, Sakurai T, Sato A, Ichihara S, Wu W, Tran L, Boland; G. Ichihara
    • Organizer
      Nano Tox 2018-9th International Conference on Nanotoxicology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] タバコの煙による左心室肥大に関連するタンパク質の同定2018

    • Author(s)
      鴇巣正樹、市原佐保子、北村祐貴、及川伸二、市原学
    • Organizer
      第13回ナノ・バイオメディカル学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 1,2-ジクロロプロパン曝露マウスにおける肝臓のプロテオミクス2018

    • Author(s)
      森川浩太、張堯、森有利絵、宗才、張霊逸、エドウィン ガーナ―、黄晋彦、呉文亭、常杰、長嶋大地、櫻井敏博、市原佐保子、及川伸二、市原学
    • Organizer
      第13回ナノ・バイオメディカル学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酸化チタンナノ粒子の物理化学的特性による影響2018

    • Author(s)
      鈴木悠加、市原学、林田有紗、渡邊英里、宗才、古谷智己、出岡淑、池上昭彦、市原佐保子
    • Organizer
      第18回分子予防環境医学研究会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] カーボンナノチューブによる血管における炎症誘導機構の解明2018

    • Author(s)
      市原佐保子, 鈴木悠加, 岩瀬優, 出岡淑, 池上 昭彦, 宗 才, 市原 学
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シリカナノ粒子の消化管上皮細胞に対する炎症反応2018

    • Author(s)
      及川(多田) 佐枝子, 江口 茉那, 吹田 佳鈴, 池上 昭彦, 市原 学, 市原 佐保子
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Surface modifications of silica nanoparticles affect their uptake by the cells and subsequent pulmonary toxicity.2017

    • Author(s)
      Sandra Vranic, Eri Watanabe, Yurika Osada, Sahoko Ichihara, Wenting Wu, Toshihiro Sakurai, Toshihiro Suzuki, Ryo Abe, Sonia Boland, Lang Tran, Gaku Ichihara.
    • Organizer
      8th International Symposium on Nanotechnology, Occupational and Environmental Health
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exposure assessment in a factory of barium sulfate particles.2017

    • Author(s)
      Sahoko Ichihara, Zhenlie Huang, Gaku Ichihara, Yuji Fujitani, Seishiro Hirano, Sakie Takeuchi, Akiho Hirano, Hanlin Huang.
    • Organizer
      Inhaled Particles XII
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 酸化チタンナノ粒子の物理化学的特性による影響2017

    • Author(s)
      林田 有紗, 市原 学, 渡辺 英里, 鈴木 悠加, 古谷 知己, 出岡 淑, 市原 佐保子
    • Organizer
      第 12 回ナノ・バイオメディカル学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effect of physicochemical characteristics of nano-sized TiO2 on adhesion of monocytes to endothelial cells.2016

    • Author(s)
      Sahoko Ichihara, Yuka Suzuki, Eri Watanabe, Arisa Hayashida, Yurika Osada, Tomoki Furutani, Kiyora Izuoka, Gaku Ichihara.
    • Organizer
      11th International Particle Toxicology Conference
    • Place of Presentation
      Singapore, Republic of Singapore
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of nano-sized TiO2 on the adhesion of monocytes to endothelial cells by the differences in the crystal structure and characteristics of the surface of nanoparticles.2016

    • Author(s)
      Gaku Ichihara, Yuka Suzuki, Eri Watanabe, Arisa Hayashida, Yurika Osada, Tomoki Furutani, Kiyora Izuoka, Sahoko Ichihara.
    • Organizer
      52nd European Congress of the European Societies of Toxicology
    • Place of Presentation
      Seville, Spain
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 酸化チタンナノ粒子の物理化学的特性による血管内皮細胞への影響の検討2016

    • Author(s)
      市原佐保子、鈴木悠加、古谷知己、出岡淑、渡邊英里、林田有紗、長田百合香、市原学
    • Organizer
      第44回産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      東京理科大学森戸記念館(東京都・新宿区)
    • Year and Date
      2016-08-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] ナノマテリアル有害性評価と労働環境衛生学2016

    • Author(s)
      市原 学, 小林 隆弘, 市原 佐保子
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち(愛知県・名古屋市)
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 吸引投与による多層カーボンナノチューブの影響とその作用機序の検討2016

    • Author(s)
      市原佐保子、鈴木悠加、呉文亭、出岡淑、伊東健、山本雅之、市原学
    • Organizer
      第86回日本衛生学会学術総会
    • Place of Presentation
      旭川市民文化会館(北海道・旭川市)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of nano-sized TiO2 on the adhesion of monocytes to endothelial cells.2016

    • Author(s)
      Sahoko Ichihara, Yuka Suzuki, Eri Watanabe, Yurika Osada, Arisa Hayashida, Tomoki Furutani, Kiyora Izioka, Gaku Ichihara.
    • Organizer
      The 55th Annual Meeting of Society of Toxicology and ToxExpo
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MicroRNAs as biomarkers for cigarette smoking and atherosclerosis.2015

    • Author(s)
      Sahoko Ichihara, Yuka Suzuki, Saeko Tada-Oikawa, Yuka Yokoyama, Kiyora Izuoka, Lingyu Zhang, Cai Zong, Gaku Ichihara.
    • Organizer
      The Scientific Sessions of American Heart Association
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genome-wide DNA metylation of myocardial infarction.2015

    • Author(s)
      Sahoko Ichihara, Masahiro Nakatochi, Tatsuaki Matsubara, Ken Yamamoto, Mitsuhiro Yokota.
    • Organizer
      The Scientific Sessions of American Heart Association
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single-wall or double-wall carbon nanotubes induce atherosclerosis progression in animal and culture models of atherosclerosis.2015

    • Author(s)
      Sahoko Ichihara, Yuka Suzuki, Saeko Tada-Oikawa, Kiyora Izuoka, Cai Zong, Gaku Ichihara.
    • Organizer
      7th International Congress of Asia Society of Toxicology (ASIATOX 2015)
    • Place of Presentation
      Jeju Island, Korea
    • Year and Date
      2015-06-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single-wall or double-wall carbon nanotubes induce atherosclerosis progression in animal and culture models of atherosclerosis.2015

    • Author(s)
      Sahoko Ichihara, Yuka Suzuki, Saeko Tada-Oikawa, Kiyora Izuoka, Cai Zong, Gaku Ichihara.
    • Organizer
      SENN2015 Congress
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2015-04-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アルツハイマー病患者の血漿中におけるプロテオミクス解析2015

    • Author(s)
      北村祐貴、宇佐美良子、木田博隆、佐藤正之、市原佐保子、松永誠治郎、水野章、冨本秀和、村田真理子、及川伸二
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山県民文化会館・ホテルアバローム紀の国
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 喫煙による動脈硬化促進における作用機序の解明2015

    • Author(s)
      市原佐保子、鈴木悠加、及川(多田)佐枝子、宗才、張霊逸、市原学
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山県民文化会館・ホテルアバローム紀の国
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 1-ブロモプロパン神経毒性のマウスモデルの確立2015

    • Author(s)
      宗才、黄晋彦、エドウィン ガーナ、張霊逸、張堯、加藤昌志、市原佐保子、市原学
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山県民文化会館・ホテルアバローム紀の国
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 単球の血管内皮細胞への接着能に及ぼす酸化チタンナノ粒子の影響2015

    • Author(s)
      鈴木悠加、市原学、及川(多田)佐枝子、村上理彦、出岡淑、市原佐保子
    • Organizer
      第14回分子予防環境医学研究会
    • Place of Presentation
      大阪市立大学医学部 学舎4階 中講義室1
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中国酸化チタン粒子取扱工場労働者に対する心肺機能を中心とした調査研究2014

    • Author(s)
      市原佐保子、李衛華、尾村誠一、藤谷雄二、平工雄介、久永直見、丁訓誠、小林隆弘、市原学
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] コホート研究による動脈硬化症の発症要因における喫煙の影響の検討2014

    • Author(s)
      市原 佐保子、及川(多田)佐枝子、菅原望、水野章、山田芳司
    • Organizer
      第84回日本衛生学会総会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 単層、二層カーボンナノチューブによる動脈硬化症への影響とその作用機序の検討2014

    • Author(s)
      鈴木悠加、市原学、宗才、及川(多田)佐枝子、出岡淑、市原佐保子
    • Organizer
      第84回日本衛生学会総会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 酸化亜鉛ナノ粒子の血管内皮前駆細胞に対する影響2014

    • Author(s)
      及川(多田)佐枝子、市原学、鈴木悠加、出岡淑、三島隆、市原佐保子
    • Organizer
      第84回日本衛生学会総会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Biodistribution and effects of SiO2 NPs in mice and in a transgenic model of zebrafish (Danio rerio).2014

    • Author(s)
      Sandra Vranic, Sahoko Ichihara, Yasuhito Shimada, Toshio Tanaka, Wenting Wu, Sonja Boland, Lang Tran, Gaku Ichihara
    • Organizer
      The 7th International Congress of Nanotoxicology
    • Place of Presentation
      The Congress Center in Limra Hotel & Resort, Antalya, Turkey
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2020-03-30  

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