Global survey analysis of drug-resistant anti-biogram evolution pattern of MRSA

• Project/Area Number: 26305034
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Niigata University
• Principal Investigator: TERAO Yutaka 新潟大学, 医歯学系, 教授 (50397717)
• Co-Investigator(Kenkyū-buntansha): 土門 久哲 新潟大学, 医歯学総合病院, その他 (00594350) ; 石田 陽子 新潟大学, 医歯(薬)学総合研究科, 研究員 (10377187) ; 小田 真隆 京都薬科大学, 薬学部, 教授 (00412403) ; 上原 良雄 新潟大学, 医歯(薬)学総合研究科, その他 (60346723)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
• Keywords: 誤嚥性肺炎 / MRSA

Outline of Final Research Achievements

Staphylococcus aureus is frequently separated from aspiration pneumonitis lesions of the elderly and oropharynx. Staphylococcus aureus is recognized as an intractable bacterial species by being tolerated by the frequent use of antibiotics and called"Methicillin-resistant Staphylococcus aureus (MRSA)". An analysis experiment of bacterial genes was performed using collected a lot of MRSA bacterial strains. As a result, in addition to the conventional determinant of MRSA resistance evolution, "enhancement of drug resistance by uptake of foreign genes", "mutation at the chromosomal DNA level of MRSA itself" is also involved in tolerance I got a suggestion. Also, there was a certain pattern in the evolution of tolerance, suggesting that it can be illustrated by an "anti - biogram" model.

Research Products

• [Journal Article] Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-like Receptors and Cytokines in Pneumococcal Pneumonia. (2018)
  • Author(s): Domon H, Nagai K, Maekawa T, Oda M, Yonezawa D, Takeda W, Hiyoshi T, Tamura H, Yamaguchi M, Kawabata S, Terao Y
  • Journal Title: Front Immunol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Sulfated vizantin induces the formation of macrophage extracellular traps. (2018)
  • Author(s): Oda M, Kurosawa M, Yamamoto H, Domon H, Kimura T, Isono T, Maekawa T, Hayashi N, Yamada N, Furue Y, Kai D, Terao Y
  • Journal Title: Microbiol Immunol Volume: 印刷中
  • NAID: 40021560445
  • Peer Reviewed
• [Journal Article] The effect of chlorhexidine on dental calculus formation: an in vitro study. (2018)
  • Author(s): Sakaue Y, Takenaka S, Ohsumi T, Domon H, Terao Y, Noiri Y
  • Journal Title: BMC Oral Health Volume: 18 Pages: 52-52
  • Peer Reviewed
• [Journal Article] Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection. (2018)
  • Author(s): Sumitomo T, Mori Y, Nakamura Y, Honda-Ogawa M, Nakagawa S, Yamaguchi M, Matsue H, Terao Y, Nakata M, Kawabata S
  • Journal Title: Front Cell Infect Microbiol Volume: 8 Pages: 10-10
  • Peer Reviewed
• [Journal Article] Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. (2018)
  • Author(s): Nagai K, Domon H., Maekawa T, Oda M, Hiyoshi T, Tamura H, Yonezawa D, Arai Y, Yokoji M, Tabeta K, Habuka R, Saitoh A, Yamaguchi M, Kawabata S, Terao Y
  • Journal Title: Cell Immunol Volume: 325 Pages: 14-22
  • Peer Reviewed
• [Journal Article] Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway. (2018)
  • Author(s): Kurosawa M, Oda M, Domon H, Isono T, Nakamura Y, Saitoh I, Hayasaki H, Yamaguchi M, Kawabata S, Terao Y:
  • Journal Title: Microb Infect, Volume: 20 Pages: 9-18
  • Peer Reviewed
• [Journal Article] Streptococcus pyogenes phospholipase A2 induces the expression of adhesion molecules on human umbilical vein endothelial cells and aorta of mice. (2017)
  • Author(s): Oda M, Domon H, Kurosawa M, Isono T, Maekawa T, Yamaguchi M, Kawabata S, Terao Y
  • Journal Title: Front Cell Infect Microbiol Volume: 7 Pages: 300-300
  • Peer Reviewed
• [Journal Article] Differential expression and roles of secreted frizzled-related protein 5 （Sfrp5）and the wingless homolog Wnt5a in periodontitis. (2017)
  • Author(s): Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G
  • Journal Title: J Dent Res Volume: 96 Pages: 571-577
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] solation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers. (2017)
  • Author(s): Murakami T, Saitoh I, Sato M, Inada E, Soda M, Oda M, Domon H, Iwase Y, Sawami T, Matsueda K, Terao Y, Ohshima H, Noguchi H, Hayasaki H
  • Journal Title: Arch Oral Biol Volume: 81 Pages: 110-120
  • Peer Reviewed
• [Journal Article] Differential Expression and Roles of Secreted Frizzled-Related Protein and the Wingless Homolog Wnt5a in Periodontitis. (2017)
  • Author(s): Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G.
  • Journal Title: J Dent Res Volume: 96(5) Issue: 5 Pages: 571-577
  • DOI: 10.1177/0022034516687248
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Milk fat globule epidermal growth factor 8 inhibits periodontitis in non-human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans (2017)
  • Author(s): Kajikawa T., Meshikhes F., Maekawa T., Hajishengallis E., Hosur K. B., Abe T., Moss K., Chavakis T., Hajishengallis G.
  • Journal Title: J Clin Periodontol Volume: jcpe.12707 Issue: 5 Pages: 472-483
  • DOI: 10.1111/jcpe.12707
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria. (2016)
  • Author(s): Nagai K, Domon H, Oda M, Shirai T, Ohsumi T, Terao Y, Arai Y:
  • Journal Title: Dent Mater J Volume: 480 Pages: 173-179
  • NAID: 130006224952
  • Peer Reviewed
• [Journal Article] Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis (2016)
  • Author(s): Domon H, Oda M, Maekawa T, Nagai K, Takeda W, Terao Y:
  • Journal Title: Sci Rep Volume: 6 Pages: 38013-38013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Adverse Influences of Antimicrobial Strategy against Mature Oral Biofilm (2016)
  • Author(s): Takenaka S, Oda M, Domon H, Wakamatsu R, Ohsumi T, Terao Y, Noiri Y
  • Journal Title: Microbial Biofilms - Importance and Applications Volume: 18
  • DOI: 10.5772/63564
  • ISBN: 9789535124351, 9789535124368
  • Peer Reviewed
• [Journal Article] Vizantin inhibits bacterial adhesion without affecting bacterial growth and causes Streptococcus mutans biofilm to detach by altering its internal architecture (2016)
  • Author(s): Takenaka S, Oda M, Domon H, Ohsumi T, Suzuki Y, Ohshima H, Yamamoto H, Terao Y, Noiri Y
  • Journal Title: Biochem Biophys Res Commun Volume: 480 Pages: 173-179
  • Peer Reviewed
• [Journal Article] シリーズバイオセーフティ (2016)
  • Author(s): 寺尾 豊
  • Journal Title: BMSAジャーナル Volume: 28(3) Pages: 99-103
• [Journal Article] 劇症型溶血性レンサ球菌感染症（人食いバクテリア） (2016)
  • Author(s): 寺尾 豊，黒澤美絵
  • Journal Title: 感染・炎症・免疫 Volume: 7 Pages: 76-78
• [Journal Article] Chemical hybridization of Vizantin and Lipid A to generate a novel LPS antagonist. (2016)
  • Author(s): Yamamoto H, Oda M, Kanno M, Tamashiro S, Tamura I, Yoneda T, Yamasaki N, Domon H, Nakano M, Takahashi H, Terao Y, Kasai Y, Imagawa H
  • Journal Title: Chem Pham Bull Volume: 64 Pages: 246-257
  • NAID: 130005131585
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Anti-biofilm and bactericidal effects of Magnolia bark-derived magnolol and honokiol on Streptococcus mutans. (2016)
  • Author(s): Sakaue Y, Domon H, Oda M, Takenaka S, Kubo M, Fukuyama Y, Okiji T, Terao Y
  • Journal Title: Microbiol Immunol Volume: 60 Pages: 10-16
  • NAID: 40020725379
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells. (2016)
  • Author(s): Kurosawa M, Oda M, Domon H, Saitoh I, Hayasaki H, Terao Y
  • Journal Title: Microb Infect Volume: 18 Pages: 118-127
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Poor survival of Methicillin-resistant Staphylococcus aureus on inanimate objects in the public spaces. (2016)
  • Author(s): Domon H, Uehara Y, Oda M, Seo H, Kubota N, Terao Y
  • Journal Title: MicrobiologyOpen Volume: 5 Pages: 39-46
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Membrane-binding mechanism of Clostridium perfringens alpha-toxin. (2015)
  • Author(s): Oda M, Terao Y, Sakurai J, Nagahama M
  • Journal Title: Toxins Volume: 7 Pages: 5268-5275
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Total synthesis of palau’amine. (2015)
  • Author(s): Namba K, Takeuchi K, Kaihara Y, Oda M, Nakayama A, Nakayama A, Yoshida M, Tanino K
  • Journal Title: Nat Commun Volume: 6 Pages: 8731-8731
  • NAID: 120006999407
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Identification of the replication region in pBCNF5603, a bacteriocin-encoding plasmid, in the enterotoxigenic Clostridium perfringens strain F5603. (2015)
  • Author(s): Miyamoto K, Seike S, Takagishi T, Okui K, Oda M, Takehara M, Nagahama M
  • Journal Title: BMC Microbial Volume: 15 Pages: 118-118
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Tetranorsesquiterpenoids and santalane-type sesquiterpenoids from Illicium lanceolatum and their antimicrobial activity against the oral pathogen Porphyromonas gingivalis. (2015)
  • Author(s): Kubo M, Nishikawa Y, Harada K, Oda M, Huang JM, Domon H, Terao Y, Fukuyama Y
  • Journal Title: J Nat Prod Volume: 78 Pages: 1466-1469
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clostridium perfringens alpha-toxin induces GM1a clustering and TrkA phosphorylation in the host cell membrane. (2015)
  • Author(s): Takagishi T, Oda M, Kabura M, Kurosawa M, Tominaga K, Urano S, Ueda Y, Kobayashi K, Kobayashi T, Sakurai J, Terao Y, Nagahama M
  • Journal Title: PLoS one Volume: 10
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clostridium perfringens alpha-toxin induces GM1a clustering and TrkA phosphorylation in the host cell membrane. (2015)
  • Author(s): Takagishi, T., Oda, M., Kabura, M., Kurosawa, M., Tominaga, K., Urano, S., Ueda, Y.,Kobayashi, K., Kobayashi, T., Sakurai, J., Terao, Y., and Nagahama, M.
  • Journal Title: PLoS one Volume: in press
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice. (2015)
  • Author(s): Yamada, H., Nakajima, T., Domon, H., Honda, T., and Yamazaki, K.:
  • Journal Title: J. Periodontal Res. Volume: in press
  • Peer Reviewed
• [Journal Article] Residual structure of Streptococcus mutans biofilm following complete disinfection favors secondary bacterial adhesion and biofilm re-development. (2015)
  • Author(s): Ohsumi, T., Takenaka, S., Wakamatsu, R., Sakaue, Y., Narisawa, N., Senpuku, H., Ohshima, H., Terao, Y., and Okiji, T.
  • Journal Title: PLoS one Volume: 10
  • Peer Reviewed
• [Journal Article] Vizantin inhibits endotoxin-mediated immune responses via the Toll-like receptor 4/MD-2 complex. (2014)
  • Author(s): Oda, M., Yamamoto, H., Shibutani, M., Nakano, M., Yabiku, K., Tarui, T., Kameyama, N., Shirakawa, D., Obayashi, S., Watanabe, N., Nakase, H., Suenaga, M., Matsunaga, Y., Nagahama, M., Takahashi, H., Imagawa, H., Kurosawa, M., Terao, Y., Nishizawa, M., and Sakurai, J.
  • Journal Title: J. Immunol. Volume: 193 Pages: 4507-4514
  • Peer Reviewed
• [Journal Article] Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis. (2014)
  • Author(s): Domon, H., Nakajima, T., Tabeta, K., and Yamazaki, K.
  • Journal Title: J. Periodontal Res. Volume: 49 Pages: 536-543
  • Peer Reviewed
• [Presentation] 肺炎球菌性肺炎の重症化カスケード ―細菌由来病原因子と好中球由来防御因子のせめぎ合い― (2018)
  • Author(s): 土門久哲，寺尾 豊
  • Organizer: 第91回日本細菌学会総会
  • Invited
• [Presentation] Pneumococcal DNA-binding proteins released by autolysis induce inflammatory cytokine production. (2018)
  • Author(s): 永井康介，土門久哲，前川知樹，山口雅也，川端重忠，寺尾 豊
  • Organizer: 第91回日本細菌学会総会
• [Presentation] 口腔領域の病原細菌に対するヒノキチオールの抗菌作用解析 (2018)
  • Author(s): 土門久哲，國友栄治，寺尾 豊
  • Organizer: 第91回日本細菌学会総会
• [Presentation] 肺炎球菌感染時における好中球エラスターゼのin vitro機能解析 (2017)
  • Author(s): 土門久哲，前川知樹，永井康介，寺尾 豊
  • Organizer: 第90回日本細菌学会総会
  • Place of Presentation: 仙台国際ホール（宮城県仙台市）
  • Year and Date: 2017-03-20
• [Presentation] 誤嚥性肺炎に対する新規感染制御法の開発に向けた多次元解析 (2017)
  • Author(s): 土門久哲
  • Organizer: 第１回D3研究交流会
  • Place of Presentation: ときめいと（新潟県新潟市）
  • Year and Date: 2017-01-24
• [Presentation] 血管が作り出す生体由来の分子による歯周病マーカーの開発と応用研究 (2017)
  • Author(s): 前川知樹
  • Organizer: 第１回D3研究交流会
  • Place of Presentation: ときめいと（新潟県新潟市）
  • Year and Date: 2017-01-24
• [Presentation] Streptococcal cysteine protease-mediated cleavage of desmogleins contributes to development of cutaneous infections. (2017)
  • Author(s): Sumitomo T, Mori Y, Nakamura Y, Honda-Ogawa M, Yamaguchi M, Terao Y, Nakata M, Kawabata S
  • Organizer: IUMS 2017
  • Int'l Joint Research
• [Presentation] Differential Expression and Roles of Sfrp5 and Wnt5a in Periodontitis. (2017)
  • Author(s): Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Terao Y, Maeda T, Hajishengallis G
  • Organizer: 95th General Session & Exhibition of the IADR
  • Int'l Joint Research
• [Presentation] 抗炎症性分子 Del-1 は Wnt5a-Ror2 伝達経路を阻害し骨吸収を抑制する (2017)
  • Author(s): 前川知樹，小林泰浩，土門久哲，永井康介，寺尾 豊，前田健康
  • Organizer: 第59回歯科基礎医学会学術大会
• [Presentation] 自己溶菌に伴い放出される肺炎球菌の菌体内病原因子の同定と分子解析 (2017)
  • Author(s): 永井康介，土門久哲，前川知樹，山口雅也，川端重忠，寺尾 豊
  • Organizer: 第59回歯科基礎医学会学術大会
• [Presentation] 肺炎の重症化に伴い誘導される宿主由来エラスターゼの病原性解析 (2017)
  • Author(s): 土門久哲，前川知樹，永井康介，山口雅也，川端重忠，寺尾 豊
  • Organizer: 第59回歯科基礎医学会学術大会
• [Presentation] ヒト好中球を利用する肺炎球菌の感染メカニズム解析 (2017)
  • Author(s): 土門久哲，前川知樹，永井康介，寺尾 豊
  • Organizer: 第１回 オーラルサイエンス研究会
• [Presentation] 食物由来ペプチドを用いた炎症と骨吸収制御機構の検索 (2017)
  • Author(s): 田村 光, 前川知樹，米澤大輔，土門久哲，永井康介，日吉 巧，前田健康，寺尾 豊
  • Organizer: 第5回五大学・口腔微生物研究会
• [Presentation] Aggregatibacter actinomycetemcomitans leukotoxin およびcytolethal distending toxin 組換え体の宿主細胞に対する作用解析 (2017)
  • Author(s): 日吉 巧，土門久哲，永井康介，前川知樹，米澤大輔，田村 光，吉田明弘，寺尾 豊
  • Organizer: 第5回五大学・口腔微生物研究会
• [Presentation] 自己溶菌で漏出する肺炎球菌の菌体内病原因子の検索 (2017)
  • Author(s): 永井康介，土門久哲，前川知樹，横地麻衣，多部田康一，寺尾 豊
  • Organizer: 第49回レンサ球菌研究会
• [Presentation] 肺炎球菌が誘導する宿主由来エラスターゼによる自然免疫抑制メカニズム (2017)
  • Author(s): 土門久哲，前川知樹，永井康介，寺尾 豊
  • Organizer: 第49回レンサ球菌研究会
• [Presentation] Streptococcus pyogengesの咽頭上皮細胞株への付着・侵入におけるCAMP factorとPI3K/Akt経路との関係 (2017)
  • Author(s): 黒澤美絵，小田真隆，土門久哲，斎藤一誠，早﨑治明，寺尾 豊
  • Organizer: 第49回レンサ球菌研究会
• [Presentation] Streptococcus pyogenges PLA2による血管内皮細胞への単球付着メカニズム (2017)
  • Author(s): 磯野俊仁，小田真隆，土門久哲，前川知樹，黒澤美絵，寺尾 豊
  • Organizer: 第49回レンサ球菌研究会
• [Presentation] 食品由来ペプチドを用いた 誤嚥性肺炎感染制御法の検索 (2016)
  • Author(s): 土門久哲
  • Organizer: 第1回U-goサロン
  • Place of Presentation: 新潟大学（新潟県新潟市）
  • Year and Date: 2016-12-05
• [Presentation] 内因性Del-1分子による炎症性骨吸収の制御メカニズム解析とサルの応用研究 (2016)
  • Author(s): 前川知樹
  • Organizer: 第19回骨代謝研究会
  • Place of Presentation: 慶応大学（東京都新宿区）
  • Year and Date: 2016-11-26
  • Invited
• [Presentation] Keystone細菌と生体の相互作用 (2016)
  • Author(s): 前川知樹
  • Organizer: 第69回日本細菌学会関西支部総会
  • Place of Presentation: 大阪市立大学（大阪府堺市）
  • Year and Date: 2016-11-19
  • Invited
• [Presentation] Streptococcus pyogenesによる皮膚病変の形成機構に関する解析 (2016)
  • Author(s): 毛利泰士，住友倫子，松岡悠美，本多真理子，山口雅也，寺尾 豊，中田匡宣，川端重忠
  • Organizer: 第69回日本細菌学会関西支部総会
  • Place of Presentation: 大阪市立大学（大阪府堺市）
  • Year and Date: 2016-11-16
• [Presentation] 肺炎球菌性肺炎の重症化メカニズムの分子解析 (2016)
  • Author(s): 土門久哲，小田真隆，川端重忠，寺尾 豊
  • Organizer: 第65回日本感染症学会東日本地方会学術集会
  • Place of Presentation: 朱鷺メッセ（新潟県新潟市）
  • Year and Date: 2016-10-27
• [Presentation] 結核表層糖脂質誘導体のStreptococcus mutansバイオフィルム形成に与える影響 (2016)
  • Author(s): 竹中彰治，小田真隆，黒澤美絵，土門久哲，大墨竜也，寺尾 豊，野杁由一郎
  • Organizer: 日本歯科保存学会2016年度秋期学術大会
  • Place of Presentation: 松本歯科大学（長野県塩尻市）
  • Year and Date: 2016-10-26
• [Presentation] ：A群レンサ球菌のPI3K/Akt活性化因子を介した咽頭上皮細胞株への付着・侵入メカニズムの解析 (2016)
  • Author(s): 黒澤美絵，小田真隆，土門久哲，齊藤一誠，早﨑治明，寺尾 豊
  • Organizer: 第58回歯科基礎医学会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-08-25
• [Presentation] Porphyromonas gingivalisは補体C5aとTLRを利用して免疫系から回避する (2016)
  • Author(s): 前川知樹，前田健康，寺尾 豊
  • Organizer: 第58回歯科基礎医学会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-08-25
• [Presentation] Streptococcus pneumoniaeの肺組織障害におけるカスケード機構の解析 (2016)
  • Author(s): 寺尾 豊，土門久哲
  • Organizer: 第48回レンサ球菌研究会，
  • Place of Presentation: 長崎大学（長崎県長崎市）
  • Year and Date: 2016-07-09
  • Invited
• [Presentation] 肺炎球菌の自己融解に起点を発する肺傷害のカスケード機構 (2016)
  • Author(s): 土門久哲，小田真隆，寺尾 豊
  • Organizer: 第55回新潟化学療法研究会
  • Place of Presentation: ANAクラウンプラザホテル（新潟県新潟市）
  • Year and Date: 2016-07-02
• [Presentation] Inhibition of periodontitis in non-human primates by a locally administered complement C3 inhibitor. (2016)
  • Author(s): Maekawa T, Maeda T, Hajishengallis E
  • Organizer: 94th General Session & Exhibition of the IADR
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] 多機能性糖脂質によるマクロファージ細胞外捕獲網形成機構の解明 (2016)
  • Author(s): 小田真隆，黒澤美絵，土門久哲，寺尾 豊
  • Organizer: 第89回日本細菌学会総会
  • Place of Presentation: 大阪国際交流センター 大ホール（大阪府・大阪市）
  • Year and Date: 2016-03-23
• [Presentation] 肺炎球菌による肺組織傷害誘導メカニズムの解析 (2016)
  • Author(s): 土門久哲，坂上雄樹，小田真隆，山口雅也，川端重忠，寺尾 豊
  • Organizer: 第89回日本細菌学会総会
  • Place of Presentation: 大阪国際交流センター 大ホール（大阪府・大阪市）
  • Year and Date: 2016-03-23
• [Presentation] Streptococcus pyogenesの咽頭上皮細胞株への付着・侵入におけるCAMP factorの役割 (2016)
  • Author(s): 黒澤美絵，小田真隆，土門久哲，寺尾 豊
  • Organizer: 第89回日本細菌学会総会
  • Place of Presentation: 大阪国際交流センター 大ホール（大阪府・大阪市）
  • Year and Date: 2016-03-23
• [Presentation] Streptococcus pyogenes CAMP factorのRAW264.7細胞に対する病原性解析 (2015)
  • Author(s): 黒澤美絵，小田真隆，土門久哲，寺尾豊
  • Organizer: 第88回日本細菌学会総会
  • Place of Presentation: 岐阜，長良川国際会議場
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Streptococcus mutansバイオフィルムに対する植物由来抽出物の検索 (2014)
  • Author(s): 坂上雄樹，土門久哲，小田真隆，興地隆史，寺尾 豊
  • Organizer: 第51回日本細菌学会中部支部総会
  • Place of Presentation: 金沢，北陸大学薬学部
  • Year and Date: 2014-10-17 – 2014-10-18
• [Presentation] Streptococcous pyogenes CAMP factorの免疫担当細胞に対する病原性解析 (2014)
  • Author(s): 黒澤美絵，小田真隆，土門久哲，寺尾 豊
  • Organizer: 第51回日本細菌学会中部支部総会
  • Place of Presentation: 金沢，北陸大学薬学部
  • Year and Date: 2014-10-17 – 2014-10-18
• [Presentation] 多機能性糖脂質の自然免疫活性化メカニズムの解明 (2014)
  • Author(s): 小田真隆，山本博文，黒澤美絵，土門久哲，寺尾 豊
  • Organizer: 第51回日本細菌学会中部支部総会
  • Place of Presentation: 金沢，北陸大学薬学部
  • Year and Date: 2014-10-17 – 2014-10-18
• [Presentation] 慢性炎症性疾患におけるT L R シグナル抑制因子の解析 (2014)
  • Author(s): 土門久哲，坂上雄樹，小田真隆，寺尾 豊
  • Organizer: 第51回日本細菌学会中部支部総会
  • Place of Presentation: 金沢，北陸大学薬学部
  • Year and Date: 2014-10-17 – 2014-10-18
• [Presentation] イメージングと細菌学研究 (2014)
  • Author(s): 寺尾 豊
  • Organizer: 第67回 日本細菌学会中国・四国支部総会
  • Place of Presentation: 徳島，徳島文理大学薬学部
  • Year and Date: 2014-10-04
  • Invited
• [Presentation] A群レンサ球菌CAMPファクターのマクロファージに対する病原性解析 (2014)
  • Author(s): 小田真隆，黒澤美絵，土門久哲，寺尾 豊
  • Organizer: 第56回歯科基礎医学会学術大会・総会
  • Place of Presentation: 福岡，福岡国際会議場
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 歯周炎におけるTLR シグナル抑制因子の解析 (2014)
  • Author(s): 土門久哲，小田真隆，寺尾 豊
  • Organizer: 第56回歯科基礎医学会学術大会・総会
  • Place of Presentation: 福岡，福岡国際会議場
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 合成糖脂質のStreptococcus mutansバイオフィルムに対する作用 (2014)
  • Author(s): 黒澤美絵，小田真隆，土門久哲，寺尾 豊
  • Organizer: 第56回歯科基礎医学会学術大会・総会
  • Place of Presentation: 福岡，福岡国際会議場
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Streptococcus mutansに対する植物由来抽出物の殺菌ならびに抗バイオフィルム効果の検討 (2014)
  • Author(s): 坂上雄樹，土門久哲，小田真隆，興地隆史，寺尾 豊
  • Organizer: 第56回歯科基礎医学会学術大会・総会
  • Place of Presentation: 福岡，福岡国際会議場
  • Year and Date: 2014-09-25 – 2014-09-27
• [Book] 微生物学，歯科衛生士書き込み式学習ノート① 専門基礎科目編 人体の構造と機能／歯・口腔の構造と機能／疾病の成り立ち及び回復過程の促進 (2018)
  • Author(s): 寺尾 豊
  • Total Pages: 294
  • Publisher: 医歯薬出版
• [Book] 口腔微生物学・免疫学 第４版第３刷改訂版 (2018)
  • Author(s): 川端重忠，小松澤 均，大原直也，寺尾 豊，浜田茂幸
  • Total Pages: 303
  • Publisher: 医歯薬出版
• [Book] 口腔微生物学・免疫学 第４版 (2015)
  • Author(s): 川端重忠，小松澤均，大原直也，寺尾 豊，浜田茂幸編
  • Total Pages: 303
  • Publisher: 医歯薬出版
• [Book] 日本歯科評論：ナノスケールの研究を歯科医学に (2014)
  • Author(s): 寺尾 豊
  • Total Pages: 181
  • Publisher: ヒョーロン・パブリッシャーズ社
• [Remarks] 研究室HPトップ
  • URL: http://www.dent.niigata-u.ac.jp/microbio/microbio.html
• [Remarks] 新潟大学歯学部微生物感染症学
  • URL: http://www.dent.niigata-u.ac.jp/microbio/microbio.html
• [Remarks] 研究者の作成するHP
  • URL: http://www.dent.niigata-u.ac.jp/microbio/microbio.html